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Patent Searching and Data


Title:
TETRAHYDROPYRAZOLOPYRIDINE DERIVATIVES AS GHRELIN RECEPTOR AGONISTS
Document Type and Number:
WIPO Patent Application WO/2016/067638
Kind Code:
A1
Abstract:
The present invention relates to novel compounds of a formula (I) or a pharmaceutically acceptable salt or solvate thereof, processes for their preparation, pharmaceutical compositions comprising them and their use in therapy, for example as modulators of the growth hormone secretagogue receptor (also referred to as the ghrelin receptor or GHSR-1a receptor) and/or for the treatment and/or prophylaxis of a disorder mediated by the ghrelin receptor.

Inventors:
IWATA YASUHIRO (JP)
KAWAMURA KIYOSHI (JP)
SUDO MASAKI (JP)
SHIMADA KAORU (JP)
KOIZUMI SHINICHI (JP)
TAKAHASHI NOBUYUKI (JP)
OBATA KEIKO (JP)
KURODA MAKIKO (JP)
Application Number:
PCT/JP2015/005496
Publication Date:
May 06, 2016
Filing Date:
November 02, 2015
Export Citation:
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Assignee:
RAQUALIA PHARMA INC (JP)
International Classes:
C07D471/04; A61K31/43; A61P1/14; A61P3/08; A61P9/00; A61P11/00; A61P25/16; A61P29/00; A61P43/00
Domestic Patent References:
WO1997024369A11997-07-10
WO1998058949A11998-12-30
WO2013175805A12013-11-28
WO2012164473A12012-12-06
Foreign References:
US20120322821A12012-12-20
Other References:
PEDRETTI, A.: "Modeling of human ghrelin receptor (hGHS-R1a) in its close state and validation by molecular docking", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, no. 8, 2007, pages 3054 - 3064, XP055278744
Attorney, Agent or Firm:
IWATANI, Ryo (1-31 Dojima 2-chome, Kita-ku, Osaka-sh, Osaka 03, JP)
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