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Title:
TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/129025
Kind Code:
A1
Abstract:
The present invention discloses a tetrahydropyrrole compound, a preparation method therefor, a pharmaceutical composition containing the same, and a use thereof. The tetrahydropyrrole compound of the present invention is represented by general formula (I). The tetrahydropyrrole compound of the present invention has better inhibitory effects on the positive symptoms of schizophrenia, and the potency thereof is equivalent to or slightly stronger than that of the positive drug olanzapine. In addition, the compound of the present invention has dual inhibitory effects on D2 receptors and DAT receptors, and is effective for treating schizophrenia and improving negative symptoms and cognitive functions, while also reducing vertebral side effects and prolactin secretion.

Inventors:
DANG, Zhu (Room 1215, Building T3 Chengkai Center, No.166 Minhong Road, Minhang District, Shanghai 1, 200031, CN)
CAI, Christine Jue (Room 1215, Building T3 Chengkai Center, No.166 Minhong Road, Minhang District, Shanghai 1, 200031, CN)
LUO, Zhen (Room 1215, Building T3 Chengkai Center, No.166 Minhong Road, Minhang District, Shanghai 1, 200031, CN)
WANG, Liugang (Room 1215, Building T3 Chengkai Center, No.166 Minhong Road, Minhang District, Shanghai 1, 200031, CN)
BAO, Dan (Room 1215, Building T3 Chengkai Center, No.166 Minhong Road, Minhang District, Shanghai 1, 200031, CN)
Application Number:
CN2018/123751
Publication Date:
July 04, 2019
Filing Date:
December 26, 2018
Export Citation:
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Assignee:
MEDICONNS (SHANGHAI) BIOPHARMACEUTICAL CO., LTD (Room 1215, Building T3 Chengkai Center, No.166 Minhong Road, Minhang District, Shanghai 1, 200031, CN)
International Classes:
C07D487/04; A61P25/18; C07D493/04; C07D495/04; C07D498/04; C07D513/00
Domestic Patent References:
WO2012074912A12012-06-07
WO2011050245A12011-04-28
WO2008063670A12008-05-29
Foreign References:
US20120157479A12012-06-21
Other References:
DONALD M. N ET AL.: "Synthesis and evaluation of ligands for D2-like receptors:The role of common pharmacophoric groups", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 17, no. 4, 31 December 2009 (2009-12-31), pages 1716 - 1723, XP025949581
PAUL L. FELDMAN ET AL.: "Phosphodiesterase Type IV Inhibition. Structure - Activity Relationships of 1, 3-Disubstituted Pyrrolidines", JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, no. 9, 31 December 1995 (1995-12-31), pages 1505 - 1510, XP002064439
YANG FEIPU ET AL.: "Research Progress of Antipsychotics", ACTA PHARMACEUTICA SINICA, vol. 12, no. 51, 12 December 2016 (2016-12-12)
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (21st Floor SFECO Mansion 681 Xiaomuqiao Road, Shanghai 2, 200032, CN)
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