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Title:
TETRAMETHYLSPIROBIINDANE-BASED PHOSPHINE-OXAZOLINE LIGAND COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/134158
Kind Code:
A1
Abstract:
Disclosed in the present invention are a tetramethylspirobiindane-based phosphine-oxazoline ligand compound, a preparation method therefor and use thereof. The phosphine-oxazoline ligand compound is a compound having the structure as shown in general formula I or an enantiomer, racemate or diastereoisomer of said compound. The phosphine-oxazoline ligand is prepared by means of a series of reaction steps, in which an inexpensive and easily available tetramethylspirobiindane diol is used as a starting material. The present invention has developed a novel phosphine-oxazoline ligand that can be used to catalyze organic reactions, can particularly be widely used in metal-catalyzed asymmetric reactions as a chiral phosphine-oxazoline ligand, and thus has economic utility and prospective industrial applicability.

Inventors:
LIN, Xufeng (No38, Zheda Road Xihu Distric, Hangzhou Zhejiang 7, 310027, CN)
SUN, Weiye (No.38, Zheda Road Xihu Distric, Hangzhou Zhejiang 7, 310027, CN)
GU, Haorui (No.38, Zheda Road Xihu Distric, Hangzhou Zhejiang 7, 310027, CN)
Application Number:
CN2018/071714
Publication Date:
July 11, 2019
Filing Date:
January 08, 2018
Export Citation:
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Assignee:
ZHEJIANG UNIVERSITY (NO.38, Zheda Road Xihu Distric, Hangzhou Zhejiang 7, 310027, CN)
International Classes:
C07F9/653; B01J31/24; B01J31/28; C07F15/00
Foreign References:
CN101565434A2009-10-28
CN1884290A2006-12-27
US5516944A1996-05-14
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO.,LTD. (Weitian WAN/Room 215, Huanghongnian Science and Technology Complex Building No.147, Yugu Road, Xihu Distric, Hangzhou Zhejiang 3, 310013, CN)
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