Title:
TETRAMETHYLSPIROINDENE SKELETON-BASED BISOXAZOLINE LIGAND COMPOUND, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/119516
Kind Code:
A1
Abstract:
Disclosed are a tetramethylspiroindene skeleton-based bisoxazoline ligand compound, an intermediate thereof, a preparation method therefor, and a use thereof. The bisoxazoline ligand compound is a compound having a structure as shown in general formula I, or an enantiomer, a racemate, or a diastereomer of the compound. The bisoxazoline ligand is prepared by a series of reaction steps starting from cheap and easily available tetramethylspiroindane diphenol. The key intermediate is a compound having a structure as shown in general formula II. The present invention develops a novel oxazoline ligand, which can be used for catalyzing organic reactions, especially as a chiral oxazoline ligand for wide use in metal-catalyzed asymmetric reactions, and has economic practicability and good industrial application prospects.
Inventors:
LIN XUFENG (CN)
GU HAORUI (CN)
SUN WEIYE (CN)
GU HAORUI (CN)
SUN WEIYE (CN)
Application Number:
PCT/CN2017/119944
Publication Date:
June 27, 2019
Filing Date:
December 29, 2017
Export Citation:
Assignee:
UNIV ZHEJIANG (CN)
International Classes:
C07D263/12; B01J31/22; C07B53/00; C07D209/08; C07D231/04
Foreign References:
| CN101412738A | 2009-04-22 | |||
| CN101671313A | 2010-03-17 | |||
| CN101560191A | 2009-10-21 |
Other References:
PAOLO FINOCCHIARO: "Synthesis and Characterization of New Organic Phosphonates Monomers as Flame Retardant Additives for Polymers", PHOSPHORUS, SULFUR, AND SILICON, vol. 8, no. 182, 15 June 2007 (2007-06-15), pages 1689 - 1701, XP008147421, ISSN: 1042-6507
BIN LIU: "Highly Enantioselective Insertion of Carbenoids into N-H Bonds Catalyzed by Copper Complexes of Chiral Spiro Bisoxazolines", J. AM. CHEM. SOC., vol. 129, no. 18, 12 April 2007 (2007-04-12), pages 5834 - 5835, XP055620652
BIN LIU: "Highly Enantioselective Insertion of Carbenoids into N-H Bonds Catalyzed by Copper Complexes of Chiral Spiro Bisoxazolines", J. AM. CHEM. SOC., vol. 129, no. 18, 12 April 2007 (2007-04-12), pages 5834 - 5835, XP055620652
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO., LTD. (CN)
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