Title:
TGF-Β SIGNAL TRANSDUCTION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2011/102436
Kind Code:
A1
Abstract:
A compound represented by formula (I) or a pharmacologically acceptable salt thereof; and use of the compound or the pharmacologically acceptable salt thereof in the prevention or treatment of TGF-β-related diseases. [In the formula, Y represents a hydrogen atom or the like; R2 represents a group represented by formula (a) or the like; R3 represents -NR8-R9- or the like; R4, R5, R6 and R7 are the same as or different from one another and independently represent a hydrogen atom or the like; and X represents a group represented by formula (b) or the like.]
Inventors:
KAKEYA HIDEAKI (JP)
HATTORI AKIRA (JP)
TAKASU YASUAKI (JP)
FUJII NOBUTAKA (JP)
OISHI SHINYA (JP)
KOJIMA SOICHI (JP)
HARA MITSUKO (JP)
HATTORI AKIRA (JP)
TAKASU YASUAKI (JP)
FUJII NOBUTAKA (JP)
OISHI SHINYA (JP)
KOJIMA SOICHI (JP)
HARA MITSUKO (JP)
Application Number:
PCT/JP2011/053428
Publication Date:
August 25, 2011
Filing Date:
February 17, 2011
Export Citation:
Assignee:
UNIV KYOTO (JP)
KAKEYA HIDEAKI (JP)
HATTORI AKIRA (JP)
TAKASU YASUAKI (JP)
FUJII NOBUTAKA (JP)
OISHI SHINYA (JP)
KOJIMA SOICHI (JP)
HARA MITSUKO (JP)
KAKEYA HIDEAKI (JP)
HATTORI AKIRA (JP)
TAKASU YASUAKI (JP)
FUJII NOBUTAKA (JP)
OISHI SHINYA (JP)
KOJIMA SOICHI (JP)
HARA MITSUKO (JP)
International Classes:
A61K31/445; C07D211/28; A61K31/4525; A61K31/4545; A61K31/496; A61K31/5377; A61P1/16; A61P3/00; A61P9/10; A61P11/00; A61P13/12; A61P17/00; A61P17/02; A61P19/02; A61P29/00; A61P35/00; A61P43/00; C07D405/12; C07D409/12
Foreign References:
| JP2004131501A | 2004-04-30 | |||
| JP2001302633A | 2001-10-31 | |||
| US6335324B1 | 2002-01-01 | |||
| JPH08509967A | 1996-10-22 | |||
| JP2005041837A | 2005-02-17 |
Other References:
KAMAL, A. ET AL.: "Base-free monosulfonylation of amines using tosyl or mesyl chloride in water", TETRAHEDRON LETTERS, vol. 49, no. 2, 2008, pages 348 - 353
FLETCHER, S.R. ET AL.: "4-(Phenylsulfonyl) piperidines: Novel, Selective, and Bioavailable 5-HT2A Receptor Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 2, 2002, pages 492 - 503
TIMAR, Z. ET AL.: "Constructing the 2- (thiobenzyl)ethyl carbamate linker via thiyl radical addition", TETRAHEDRON LETTERS, vol. 41, no. 17, 2000, pages 3173 - 3176
LUK'YANOV, A. ET AL.: "Nitrolysis of urethanes derived from secondary alcohols as a new method for the synthesis of secondary N-nitroamines", RUSSIAN CHEMICAL BULLETIN, vol. 47, no. 6, 1998, pages 1130 - 1132
WILLECOMME, B., PIPERAZINES, ANNALES DE CHIMIE, vol. 4, no. 6, 1969, PARIS, FRANCE, pages 405 - 428
CECCHETTI, V. ET AL.: "o-Chlorobenzenesulfonamidic derivatives of (aryloxy)propanolamines as beta-blocking/diuretic agents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, no. 1, 1993, pages 157 - 161
FLETCHER, S.R. ET AL.: "4-(Phenylsulfonyl) piperidines: Novel, Selective, and Bioavailable 5-HT2A Receptor Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 2, 2002, pages 492 - 503
TIMAR, Z. ET AL.: "Constructing the 2- (thiobenzyl)ethyl carbamate linker via thiyl radical addition", TETRAHEDRON LETTERS, vol. 41, no. 17, 2000, pages 3173 - 3176
LUK'YANOV, A. ET AL.: "Nitrolysis of urethanes derived from secondary alcohols as a new method for the synthesis of secondary N-nitroamines", RUSSIAN CHEMICAL BULLETIN, vol. 47, no. 6, 1998, pages 1130 - 1132
WILLECOMME, B., PIPERAZINES, ANNALES DE CHIMIE, vol. 4, no. 6, 1969, PARIS, FRANCE, pages 405 - 428
CECCHETTI, V. ET AL.: "o-Chlorobenzenesulfonamidic derivatives of (aryloxy)propanolamines as beta-blocking/diuretic agents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, no. 1, 1993, pages 157 - 161
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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Claims: