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Title:
THERANOSTIC BUBBLE PREPARATION (TB), AND METHOD FOR USING SAME
Document Type and Number:
WIPO Patent Application WO/2016/199430
Kind Code:
A1
Abstract:
Provided is a theranostic bubble preparation which makes it possible to diagnose and treat a tissue of interest by the irradiation with ultrasound such as diagnostic ultrasound and low-intensity therapeutic ultrasound. The theranostic bubble preparation comprises: a coating film comprising a lipid; and a gas enclosed in an inner cavity formed in the coating film. The coating film comprises an anionic lipid made from distearoylphosphatidylcholine (DSPC), distearoylphosphatidylglycerol (DSPG) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- [methoxy(polyethylene glycol)-2000] (DSPE-PEG2000). The gas and the mixed gas comprises perfluoropropane or perfluorobutane.

Inventors:
MARUYAMA KAZUO (JP)
SUZUKI RYO (JP)
UNGA JOHAN MIKAEL (JP)
OMATA DAIKI (JP)
ODA YUSUKE (JP)
Application Number:
PCT/JP2016/002810
Publication Date:
December 15, 2016
Filing Date:
June 10, 2016
Export Citation:
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Assignee:
UNIV TEIKYO (JP)
International Classes:
A61K31/02; A61K9/14; A61K47/24; A61K47/26; A61K47/36; A61K47/42; A61K47/48; A61K49/00; A61P13/12; A61P25/00; A61P35/00
Foreign References:
JP2011057591A2011-03-24
JP2001205061A2001-07-31
JP2003048826A2003-02-21
JP2007516957A2007-06-28
US20050025710A12005-02-03
JP2010512400A2010-04-22
JP2009161549A2009-07-23
Other References:
SAX N. ET AL.: "Optimization of Acoustic Liposomes for Improved In Vitro and In Vivo Stability.", PHARMACEUTICAL RESEARCH, vol. 30, no. 1, 2013, pages 218 - 224, XP035152043
JAVADI M. ET AL.: "Encapsulating Nanoemulsions Inside eLiposomes for Ultrasonic Drug Delivery.", LANGMUIR, vol. 28, no. 41, 2012, pages 14720 - 14729, XP055333550
Attorney, Agent or Firm:
MAEDA & PARTNERS (JP)
Patent business corporation MAEDA PATENT OFFICE (JP)
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