Title:
THERANOSTIC BUBBLE PREPARATION (TB), AND METHOD FOR USING SAME
Document Type and Number:
WIPO Patent Application WO/2016/199430
Kind Code:
A1
Abstract:
Provided is a theranostic bubble preparation which makes it possible to diagnose and treat a tissue of interest by the irradiation with ultrasound such as diagnostic ultrasound and low-intensity therapeutic ultrasound. The theranostic bubble preparation comprises: a coating film comprising a lipid; and a gas enclosed in an inner cavity formed in the coating film. The coating film comprises an anionic lipid made from distearoylphosphatidylcholine (DSPC), distearoylphosphatidylglycerol (DSPG) and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- [methoxy(polyethylene glycol)-2000] (DSPE-PEG2000). The gas and the mixed gas comprises perfluoropropane or perfluorobutane.
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Inventors:
MARUYAMA KAZUO (JP)
SUZUKI RYO (JP)
UNGA JOHAN MIKAEL (JP)
OMATA DAIKI (JP)
ODA YUSUKE (JP)
SUZUKI RYO (JP)
UNGA JOHAN MIKAEL (JP)
OMATA DAIKI (JP)
ODA YUSUKE (JP)
Application Number:
PCT/JP2016/002810
Publication Date:
December 15, 2016
Filing Date:
June 10, 2016
Export Citation:
Assignee:
UNIV TEIKYO (JP)
International Classes:
A61K31/02; A61K9/14; A61K47/24; A61K47/26; A61K47/36; A61K47/42; A61K47/48; A61K49/00; A61P13/12; A61P25/00; A61P35/00
Foreign References:
JP2011057591A | 2011-03-24 | |||
JP2001205061A | 2001-07-31 | |||
JP2003048826A | 2003-02-21 | |||
JP2007516957A | 2007-06-28 | |||
US20050025710A1 | 2005-02-03 | |||
JP2010512400A | 2010-04-22 | |||
JP2009161549A | 2009-07-23 |
Other References:
SAX N. ET AL.: "Optimization of Acoustic Liposomes for Improved In Vitro and In Vivo Stability.", PHARMACEUTICAL RESEARCH, vol. 30, no. 1, 2013, pages 218 - 224, XP035152043
JAVADI M. ET AL.: "Encapsulating Nanoemulsions Inside eLiposomes for Ultrasonic Drug Delivery.", LANGMUIR, vol. 28, no. 41, 2012, pages 14720 - 14729, XP055333550
JAVADI M. ET AL.: "Encapsulating Nanoemulsions Inside eLiposomes for Ultrasonic Drug Delivery.", LANGMUIR, vol. 28, no. 41, 2012, pages 14720 - 14729, XP055333550
Attorney, Agent or Firm:
MAEDA & PARTNERS (JP)
Patent business corporation MAEDA PATENT OFFICE (JP)
Patent business corporation MAEDA PATENT OFFICE (JP)
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