Title:
THERAPEUTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS
Document Type and Number:
WIPO Patent Application WO/2014/065341
Kind Code:
A1
Abstract:
The present invent addresses the problem of providing a medicine for treating amyotrophic lateral sclerosis, a disease for which there is currently no effective therapeutic agent, and provides a therapeutic agent for amyotrophic lateral sclerosis that contains a growth hormone secretagogue receptor (GHS-R) agonist or a pharmaceutically acceptable salt thereof. The therapeutic agent for amyotrophic lateral sclerosis contains a GHS-R agonist such as ghrelin and is for administration to an individual who is suffering from amyotrophic lateral sclerosis and who does not exhibit severe dysphagia. The individual may be an individual who is unresponsive or insufficiently responsive to existing therapeutic agents for ALS.
Inventors:
MATSUO TSUYOSHI (JP)
MURAYAMA NORIHITO (JP)
FURUYA MAYUMI (JP)
MURAYAMA NORIHITO (JP)
FURUYA MAYUMI (JP)
Application Number:
PCT/JP2013/078743
Publication Date:
May 01, 2014
Filing Date:
October 23, 2013
Export Citation:
Assignee:
DAIICHI SANKYO CO LTD (JP)
International Classes:
A61K45/00; A61K38/04; A61P21/02; C07K14/46
Domestic Patent References:
| WO2007146046A2 | 2007-12-21 | |||
| WO2001047558A1 | 2001-07-05 | |||
| WO2001007475A1 | 2001-02-01 | |||
| WO2003084983A1 | 2003-10-16 |
Foreign References:
| JP2008127377A | 2008-06-05 | |||
| JP2005239712A | 2005-09-08 | |||
| US7829589B2 | 2010-11-09 | |||
| US20120080747A1 | 2012-04-05 | |||
| US5663146A | 1997-09-02 | |||
| US5646301A | 1997-07-08 | |||
| US5536716A | 1996-07-16 | |||
| US7476653B2 | 2009-01-13 | |||
| US6576648B2 | 2003-06-10 | |||
| US6861409B2 | 2005-03-01 | |||
| EP0869968A1 | 1998-10-14 | |||
| US6576656B1 | 2003-06-10 |
Other References:
LEE S ET AL.: "Ghrelin protects spinal cord motoneurons against chronic glutamate excitotoxicity by inhibiting microglial activation", KOREAN J PHYSIOL PHARMACOL, vol. 16, no. 1, February 2012 (2012-02-01), pages 43 - 8, XP055252677
LIM E ET AL.: "Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1/2 and phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3p pathways", EXP NEUROL, vol. 230, no. 1, 2011, pages 114 - 22, XP055252678
ISAO NAGANO, MODERN PHYSICIAN, vol. 22, no. 5, 2002, pages 579 - 584, XP008179503
EXPERT OPINION ON EMERGING DRUGS, vol. 16, no. 2, 2011, pages 537 - 558
AMYOTROPHIC LATERAL SCLEROSIS, vol. 11, 2010, pages 38 - 45
NATURE, vol. 402, 1999, pages 656 - 660
PHYSIOLOGICAL REVIEWS, vol. 85, 2005, pages 495 - 522
EXPERIMENTAL NEUROLOGY, vol. 207, 2007, pages 52 - 63
MUSCLE NERVE, vol. 16, no. 6, 1993, pages 624 - 633
NEUROLOGY, vol. 71, 2008, pages 1770 - 1775
NEUROLOGY, vol. 70, 2008, pages 1004 - 1009
JOURNAL OF NEUROLOGY, vol. 258, no. 4, 2011, pages 613 - 617
NATURE NEUROSCIENCE, vol. 13, no. 7, 2010, pages 877 - 883
PULMONARY PHARMACOLOGY THERAPEUTICS, vol. 21, no. 5, 2008, pages 774 - 779
EXPERIMENTAL NEUROLOGY, vol. 230, 2011, pages 114 - 122
KOREAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 16, no. 1, 2012, pages 43 - 48
NEUROTOXICITY RESEARCH, vol. 19, 2011, pages 195 - 209
ENDOCRINOLOGY, vol. 114, no. 5, 1984, pages 1537 - 1545
JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, 1998, pages 3699 - 704
"Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 169, no. 1-2, 1999, pages 13 - 21
AMYOTROPHIC LATERAL SCLEROSIS, vol. 10, 2009, pages 85 - 94
ANNALS OF NEUROLOGY, vol. 39, 1996, pages 147 - 157
See also references of EP 2913063A4
LIM E ET AL.: "Ghrelin protects spinal cord motoneurons against chronic glutamate-induced excitotoxicity via ERK1/2 and phosphatidylinositol-3-kinase/Akt/glycogen synthase kinase-3p pathways", EXP NEUROL, vol. 230, no. 1, 2011, pages 114 - 22, XP055252678
ISAO NAGANO, MODERN PHYSICIAN, vol. 22, no. 5, 2002, pages 579 - 584, XP008179503
EXPERT OPINION ON EMERGING DRUGS, vol. 16, no. 2, 2011, pages 537 - 558
AMYOTROPHIC LATERAL SCLEROSIS, vol. 11, 2010, pages 38 - 45
NATURE, vol. 402, 1999, pages 656 - 660
PHYSIOLOGICAL REVIEWS, vol. 85, 2005, pages 495 - 522
EXPERIMENTAL NEUROLOGY, vol. 207, 2007, pages 52 - 63
MUSCLE NERVE, vol. 16, no. 6, 1993, pages 624 - 633
NEUROLOGY, vol. 71, 2008, pages 1770 - 1775
NEUROLOGY, vol. 70, 2008, pages 1004 - 1009
JOURNAL OF NEUROLOGY, vol. 258, no. 4, 2011, pages 613 - 617
NATURE NEUROSCIENCE, vol. 13, no. 7, 2010, pages 877 - 883
PULMONARY PHARMACOLOGY THERAPEUTICS, vol. 21, no. 5, 2008, pages 774 - 779
EXPERIMENTAL NEUROLOGY, vol. 230, 2011, pages 114 - 122
KOREAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, vol. 16, no. 1, 2012, pages 43 - 48
NEUROTOXICITY RESEARCH, vol. 19, 2011, pages 195 - 209
ENDOCRINOLOGY, vol. 114, no. 5, 1984, pages 1537 - 1545
JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, 1998, pages 3699 - 704
"Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
JOURNAL OF THE NEUROLOGICAL SCIENCES, vol. 169, no. 1-2, 1999, pages 13 - 21
AMYOTROPHIC LATERAL SCLEROSIS, vol. 10, 2009, pages 85 - 94
ANNALS OF NEUROLOGY, vol. 39, 1996, pages 147 - 157
See also references of EP 2913063A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)
Kimiki Ishibashi (JP)
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