Title:
THERAPEUTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS AND COMPOSITION FOR TREATMENT
Document Type and Number:
WIPO Patent Application WO/2018/043476
Kind Code:
A1
Abstract:
Provided is a therapeutic agent for amyotrophic lateral sclerosis, comprising: a compound represented by formula (1) (in formula (1), R1 each independently represents an alkyl group containing 1-6 carbon atoms or a 4-hydroxyphenethyl group, and n represents an integer of 1-3); a pharmacologically acceptable salt thereof; or a solvate of the compound and the salt, as an effective ingredient.
Inventors:
OKANO HIDEYUKI (JP)
FUJIMORI KOKI (JP)
OKUNO HIRONOBU (JP)
FUJIMORI KOKI (JP)
OKUNO HIRONOBU (JP)
Application Number:
PCT/JP2017/030899
Publication Date:
March 08, 2018
Filing Date:
August 29, 2017
Export Citation:
Assignee:
UNIV KEIO (JP)
International Classes:
A61K31/404; A61P21/00
Domestic Patent References:
| WO2012048330A2 | 2012-04-12 |
Other References:
VAN DEN BOSCH, L. ET AL.: "The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis", BIOCHIM. BIOPHYS. ACTA, vol. 1762, 2006, pages 1068 - 1082, XP027998117, DOI: doi:10.1016/j.bbadis.2006.05.002
NAGATA, E. ET AL.: "Bromocriptine Mesylate Attenuates Amyotrophic Lateral Sclerosis: A Phase 2a, Randomized, Double-Blind, Placebo- Controlled Research in Japanese Patients", PLOS ONE, vol. 11, no. 2, 24 February 2016 (2016-02-24), pages 1 - 16, XP055472583
ICHIYANAGI, N. ET AL.: "Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells", STEM CELL REPORTS, vol. 6, 12 April 2016 (2016-04-12), pages 496 - 510, XP055403116, DOI: doi:10.1016/j.stemcr.2016.02.011
See also references of EP 3508202A4
NAGATA, E. ET AL.: "Bromocriptine Mesylate Attenuates Amyotrophic Lateral Sclerosis: A Phase 2a, Randomized, Double-Blind, Placebo- Controlled Research in Japanese Patients", PLOS ONE, vol. 11, no. 2, 24 February 2016 (2016-02-24), pages 1 - 16, XP055472583
ICHIYANAGI, N. ET AL.: "Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells", STEM CELL REPORTS, vol. 6, 12 April 2016 (2016-04-12), pages 496 - 510, XP055403116, DOI: doi:10.1016/j.stemcr.2016.02.011
See also references of EP 3508202A4
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
Download PDF:
Previous Patent: GLASS, GLASS MATERIAL FOR PRESS MOLDING, OPTICAL ELEMENT BLANK, AND OPTICAL ELEMENT
Next Patent: EXTRUSION MOLDED ARTICLE
Next Patent: EXTRUSION MOLDED ARTICLE