Title:
THERAPEUTIC AGENT FOR ARTERIOSCLEROSIS
Document Type and Number:
WIPO Patent Application WO/2007/007665
Kind Code:
A1
Abstract:
A prophylactic and/or therapeutic agent for arteriosclerosis comprising an
antibody directed against platelet factor 4 (PF4) (an anti-PF4 antibody) as
an active ingredient; an inhibitor of the calcification in the blood vessel and/or
the calcification in an atherosclerotic plaque comprising an anti-PF4 antibody
as an active ingredient; an inhibitor of the differentiation of an arterial smooth
muscle cell into an osteoblast-like cell comprising an anti-PF4 antibody as
an active ingredient; and a method for inhibiting the differentiation of an arterial
smooth muscle cell into an osteoblast-like cell using an anti-PF4 antibody.
Inventors:
SUDA TATSUO (JP)
KATAGIRI TAKENOBU (JP)
KODAIRA KUNIHIKO (JP)
GOTO MASAAKI (JP)
HIGASHIO KANJI (JP)
KATAGIRI TAKENOBU (JP)
KODAIRA KUNIHIKO (JP)
GOTO MASAAKI (JP)
HIGASHIO KANJI (JP)
Application Number:
PCT/JP2006/313564
Publication Date:
January 18, 2007
Filing Date:
July 07, 2006
Export Citation:
Assignee:
SAITAMA MEDICAL SCHOOL (JP)
SUDA TATSUO (JP)
KATAGIRI TAKENOBU (JP)
KODAIRA KUNIHIKO (JP)
GOTO MASAAKI (JP)
HIGASHIO KANJI (JP)
SUDA TATSUO (JP)
KATAGIRI TAKENOBU (JP)
KODAIRA KUNIHIKO (JP)
GOTO MASAAKI (JP)
HIGASHIO KANJI (JP)
International Classes:
A61K39/395; A61P9/10
Domestic Patent References:
| WO2005065704A1 | 2005-07-21 |
Foreign References:
| JPH04228088A | 1992-08-18 | |||
| JPH07126181A | 1995-05-16 |
Other References:
SACHAIS S. ET AL.: "Platelet factor 4 (PF4) may promote atherosclerosis by two distinct mechanisms", BLOOD, vol. 96, no. 11, PART 1, 2000, pages 242A, ABSTRACT #1039, XP008075264
ERIKSSON E.E.: "Mechanisms of leukocyte recruitment to atherosclerotic lesions: future prospects", CURRENT OPINION IN LIPIDOLOGY, vol. 15, no. 5, 2004, pages 553 - 558, XP003007221
FUSTER V. ET AL.: "Increase in platelet factor 4-like activity in the initial stages of atherosclerosis in pigeons", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 82, 1977, pages 225 - 227, XP003007222
PERVUSHINA O. ET AL.: "Platelet Factor 4/CXCL4 Induces Phagocytosis and the Generation of Reactive Oxygen Metabolites in Mononuclear Phagocytes Independently of Gi Protein Activation or Intracellular Calcium Transients", JOURNAL OF IMMUNOLOGY, vol. 173, no. 3, 2004, pages 2060 - 2067, XP003005498
ERIKSSON E.E.: "Mechanisms of leukocyte recruitment to atherosclerotic lesions: future prospects", CURRENT OPINION IN LIPIDOLOGY, vol. 15, no. 5, 2004, pages 553 - 558, XP003007221
FUSTER V. ET AL.: "Increase in platelet factor 4-like activity in the initial stages of atherosclerosis in pigeons", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol. 82, 1977, pages 225 - 227, XP003007222
PERVUSHINA O. ET AL.: "Platelet Factor 4/CXCL4 Induces Phagocytosis and the Generation of Reactive Oxygen Metabolites in Mononuclear Phagocytes Independently of Gi Protein Activation or Intracellular Calcium Transients", JOURNAL OF IMMUNOLOGY, vol. 173, no. 3, 2004, pages 2060 - 2067, XP003005498
Attorney, Agent or Firm:
SHAMOTO, Ichio et al. (Section 206 New Ohtemachi Bldg., 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo 04, JP)
Download PDF:
Previous Patent: GREASE COMPOSITION FOR LUBRICATION OF RESIN AND REDUCTION GEAR
Next Patent: SEMICONDUCTOR DEVICE AND ELECTRIC DEVICE
Next Patent: SEMICONDUCTOR DEVICE AND ELECTRIC DEVICE