Title:
THERAPEUTIC AGENT FOR CENTRAL NERVOUS SYSTEM DISEASES
Document Type and Number:
WIPO Patent Application WO/2012/086474
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel therapeutic means for central nervous system diseases. Provided is a therapeutic agent for central nervous system diseases, said therapeutic agent comprising, as the active ingredient, ADAMTS-4 protein or an expression vector carrying ADAMTS-4 gene.
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Inventors:
KADOMATSU KENJI (JP)
IMAGAMA SHIRO (JP)
TAUCHI RYOJI (JP)
IMAGAMA SHIRO (JP)
TAUCHI RYOJI (JP)
Application Number:
PCT/JP2011/078846
Publication Date:
June 28, 2012
Filing Date:
December 14, 2011
Export Citation:
Assignee:
UNIV NAGOYA NAT UNIV CORP (JP)
KADOMATSU KENJI (JP)
IMAGAMA SHIRO (JP)
TAUCHI RYOJI (JP)
KADOMATSU KENJI (JP)
IMAGAMA SHIRO (JP)
TAUCHI RYOJI (JP)
International Classes:
A61K38/00; A61K48/00; A61P25/00; A61P25/28
Other References:
MICHELLE G. HAMEL ET AL.: "Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension", EXPERIMENTAL NEUROLOGY, vol. 210, no. 2, 2008, pages 428 - 440, XP022577355
TAKUYA SHUO ET AL.: "ADAMTS-4 ni yoru NGC Saibogai Ryoiki no Kiridashi Kiko no Kaiseki", ABSTRACTS OF ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN, vol. 126, no. 3, 2006, pages 104
MATT S. WEAVER ET AL.: "Processing of the Matricellular Protein Hevin in Mouse Brain Is Dependent on ADAMTS4", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 8, 19 February 2010 (2010-02-19), pages 5868 - 5877
RYOJI TAUCHI ET AL.: "Rat Sekizui Atsuza Sonsho ni Okeru ADAMTS-4 no Proteoglycan Bunkai Sayo to sono Jikusaku Saisei Koka", THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, vol. 85, no. 8, 25 August 2011 (2011-08-25), pages S1077
TAKUYA SHUO ET AL.: "ADAMTS-4 ni yoru NGC Saibogai Ryoiki no Kiridashi Kiko no Kaiseki", ABSTRACTS OF ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN, vol. 126, no. 3, 2006, pages 104
MATT S. WEAVER ET AL.: "Processing of the Matricellular Protein Hevin in Mouse Brain Is Dependent on ADAMTS4", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 8, 19 February 2010 (2010-02-19), pages 5868 - 5877
RYOJI TAUCHI ET AL.: "Rat Sekizui Atsuza Sonsho ni Okeru ADAMTS-4 no Proteoglycan Bunkai Sayo to sono Jikusaku Saisei Koka", THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, vol. 85, no. 8, 25 August 2011 (2011-08-25), pages S1077
Attorney, Agent or Firm:
HAGINO Mikiharu (JP)
Kanji Hagino (JP)
Kanji Hagino (JP)
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Claims: