Title:
THERAPEUTIC AGENT FOR CHORIORETINAL DEGENERATIVE DISEASES COMPRISING PYRIDINE-3-CARBALDEHYDE O-(PIPERIDIN-1-YL-PROPYL)-OXIME DERIVATIVE AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2010/058779
Kind Code:
A1
Abstract:
Disclosed is a novel prophylactic or therapeutic agent for chorioretinal degenerative diseases. A compound represented by general formula (1) or a salt thereof has an inhibitory effect on photoreceptor cell death and/or visual cell death in light-induced damage model mice. Therefore, the compound or the salt thereof is useful as a prophylactic or therapeutic agent for chorioretinal degenerative diseases such as age-related macular degeneration and retinitis pigmentos. In the formula, A represents a group represented by general formula (p1), (p2) or (p3); R1 represents a hydrogen atom, a lower alkyl group, an aralkyl group, a hydroxy group, or an ester of any one selected from the atom and the groups; R2 represents a hydrogen atom, or a lower alkyl group; R3 represents a halogen atom, a hydrogen atom, a lower alkyl group, a hydroxy group, or an ester of any one selected from the atoms and the groups, and R4 represents a halogen atom, a hydrogen atom, a hydroxy group, a lower alkoxy group, an amino group, a lower alkylamino group, or a lower cycloalkylamino group, provided that R3, R4 and a nitrogen atom may together form an unsaturated [1,2,4]oxadiazine ring; R5 represents a hydrogen atom, a lower alkyl group, or a lower cycloalkyl group; m represents a number of 0 or 1; and n represents a number of 0 or 1.
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Inventors:
HIRAI, Shin-ichiro (8916-16, Takayama-cho, Ikoma-sh, Nara 01, 〒6300101, JP)
平井 慎一郎 (〒01 奈良県生駒市高山町８９１６－１６ 参天製薬株式会社内 Nara, 〒6300101, JP)
平井 慎一郎 (〒01 奈良県生駒市高山町８９１６－１６ 参天製薬株式会社内 Nara, 〒6300101, JP)
Application Number:
JP2009/069526
Publication Date:
May 27, 2010
Filing Date:
November 18, 2009
Export Citation:
Assignee:
SANTEN PHARMACEUTICAL CO., LTD. (9-19, Shimoshinjo 3-chome Higashiyodogawa-ku, Osaka-sh, Osaka 51, 〒5338651, JP)
参天製薬株式会社 (〒51 大阪府大阪市東淀川区下新庄３丁目９番１９号 Osaka, 〒5338651, JP)
HIRAI, Shin-ichiro (8916-16, Takayama-cho, Ikoma-sh, Nara 01, 〒6300101, JP)
参天製薬株式会社 (〒51 大阪府大阪市東淀川区下新庄３丁目９番１９号 Osaka, 〒5338651, JP)
HIRAI, Shin-ichiro (8916-16, Takayama-cho, Ikoma-sh, Nara 01, 〒6300101, JP)
International Classes:
A61K31/4545; A61K31/5395; A61P27/02
Attorney, Agent or Firm:
HIBI, Norihiko et al. (3rd Floor Inaba Building, 13-18, Nishishinsaibashi 1-chome, Chuo-ku, Osaka-sh, Osaka 86, 〒5420086, JP)
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