Title:
THERAPEUTIC AGENT FOR DEMYELINATING DISEASE
Document Type and Number:
WIPO Patent Application WO/2014/115885
Kind Code:
A1
Abstract:
The present invention provides a novel therapeutic agent for demyelinating disease which acts to suppress the demyelination of the neuroaxis. The present invention provides a therapeutic agent for demyelinating disease, the therapeutic agent comprising a cyclic phosphatidic acid, a carbacyclic phosphatidic acid, a thiacyclic phosphatidic acid, or a salt of the same.
Inventors:
MUROFUSHI KIMIKO (JP)
GOTOH MARI (JP)
MARUYAMA KEI (JP)
YOSHIKAWA KEISUKE (JP)
YAMAMOTO SHINJI (JP)
GOTOH MARI (JP)
MARUYAMA KEI (JP)
YOSHIKAWA KEISUKE (JP)
YAMAMOTO SHINJI (JP)
Application Number:
PCT/JP2014/051748
Publication Date:
July 31, 2014
Filing Date:
January 28, 2014
Export Citation:
Assignee:
OCHANOMIZU UNIVERSITY (JP)
UNIV SAITAMA MEDICAL (JP)
UNIV SAITAMA MEDICAL (JP)
International Classes:
A61K31/661; A61K31/662; A61P25/00
Domestic Patent References:
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| WO2008081580A1 | 2008-07-10 | |||
| WO2003104246A1 | 2003-12-18 | |||
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| JP2002308779A | 2002-10-23 | |||
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Other References:
NOZAKI, EMI ET AL.: "Pharmacological evaluation of a novel cyclic phosphatidic acid derivative 3-S-cyclic phosphatidic acid", BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 20, 2012, pages 3196 - 3201, XP028422754
HO, PEGGY P. ET AL.: "Identification of naturally occurring fatty acids of the myelin sheath that resolve neuroinflammation", SCIENCE TRANSLATIONAL MEDICINE, vol. 4, no. 137, 2012, pages 137RA73, XP055267030
MURAKAMI-MUROFUSHI, K. ET AL., J. BIOL. CHEM., vol. 267, 1992, pages 21512 - 21517
KOBAYASHI, S. ET AL., TETRAHEDRON LETT., vol. 34, 1993, pages 4047 - 4050
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, 2011, pages 4180 - 4182
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, 2012, pages 3196 - 3201
UCHIYAMA A. ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1771, 2007, pages 103 - 112
"Pharmaceutical Society of Japan, the 23rd Symposium regarding the Progress of Reaction and Synthesis", 17 November 1997, CITIZENS HALL KUMAMOTO
SYNTHESIS OF CYCLIC PHOSPHATIDIC ACID AND CARBA DERIVATIVES AND PHYSIOLOGICAL ACTION THEREOF, pages 101 - 104
O. TORKILDSEN ET AL., ACTA NEUROL SCAND, vol. 117, no. 188, 2008, pages 72 - 76
GLENN K. MATSUSHIMA ET AL., BRAIN PATHOLOGY, vol. 11, 2001, pages 107 - 116
K. YOSHIKAWA ET AL., PROSTAGLANDINS, LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, vol. 85, 2011, pages 43 - 52
EMI NOZAKI, BIOCHIMICA ET BIOPHYSICA ACTA, 2011
HO, PEGGY P. ET AL.: "Identification of naturally occurring fatty acids of the myelin sheath that resolve neuroinflammation", SCIENCE TRANSLATIONAL MEDICINE, vol. 4, no. 137, 2012, pages 137RA73, XP055267030
MURAKAMI-MUROFUSHI, K. ET AL., J. BIOL. CHEM., vol. 267, 1992, pages 21512 - 21517
KOBAYASHI, S. ET AL., TETRAHEDRON LETT., vol. 34, 1993, pages 4047 - 4050
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, 2011, pages 4180 - 4182
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, 2012, pages 3196 - 3201
UCHIYAMA A. ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1771, 2007, pages 103 - 112
"Pharmaceutical Society of Japan, the 23rd Symposium regarding the Progress of Reaction and Synthesis", 17 November 1997, CITIZENS HALL KUMAMOTO
SYNTHESIS OF CYCLIC PHOSPHATIDIC ACID AND CARBA DERIVATIVES AND PHYSIOLOGICAL ACTION THEREOF, pages 101 - 104
O. TORKILDSEN ET AL., ACTA NEUROL SCAND, vol. 117, no. 188, 2008, pages 72 - 76
GLENN K. MATSUSHIMA ET AL., BRAIN PATHOLOGY, vol. 11, 2001, pages 107 - 116
K. YOSHIKAWA ET AL., PROSTAGLANDINS, LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, vol. 85, 2011, pages 43 - 52
EMI NOZAKI, BIOCHIMICA ET BIOPHYSICA ACTA, 2011
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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