Title:
THERAPEUTIC AGENT FOR DIABETES
Document Type and Number:
WIPO Patent Application WO/2014/123203
Kind Code:
A1
Abstract:
Provided is a compound having PTP-1B inhibitory activity that is excellent as a drug, or a pharmaceutically acceptable salt thereof. A compound represented by general formula (I) (in the formula, each symbol means the same as in the specification), or a pharmaceutically acceptable salt thereof.
Inventors:
TANAKA SHUNKICHI (JP)
FUKUI MASAKI (JP)
OTAKE KAZUYA (JP)
KASAI MASAYASU (JP)
SHIRAHASE HIROAKI (JP)
FUKUI MASAKI (JP)
OTAKE KAZUYA (JP)
KASAI MASAYASU (JP)
SHIRAHASE HIROAKI (JP)
Application Number:
PCT/JP2014/052803
Publication Date:
August 14, 2014
Filing Date:
February 06, 2014
Export Citation:
Assignee:
KYOTO PHARMA IND (JP)
International Classes:
C07C311/51; A61K31/341; A61K31/343; A61K31/381; A61K31/395; A61K31/40; A61K31/403; A61K31/415; A61K31/4155; A61K31/4184; A61K31/42; A61K31/421; A61K31/4245; A61K31/426; A61K31/433; A61K31/47; A61K31/50; A61K31/501; A61P3/04; A61P3/06; A61P3/10; A61P5/50; A61P9/10; A61P29/00; A61P35/00; A61P43/00; C07D207/325; C07D209/08; C07D209/42; C07D209/82; C07D215/48; C07D225/02; C07D231/12; C07D235/26; C07D237/14; C07D261/10; C07D263/32; C07D271/06; C07D277/24; C07D277/26; C07D277/64; C07D285/12; C07D307/42; C07D307/85; C07D333/16; C07D333/38; C07D333/76; C07D403/04; C07D405/12; C07D409/12; C07D417/04
Domestic Patent References:
| WO2009109999A1 | 2009-09-11 | |||
| WO2011102514A1 | 2011-08-25 | |||
| WO2011059042A1 | 2011-05-19 | |||
| WO2011024468A1 | 2011-03-03 | |||
| WO2000034277A1 | 2000-06-15 |
Foreign References:
| JP2007523903A | 2007-08-23 | |||
| JP2007532632A | 2007-11-15 | |||
| JP2007516258A | 2007-06-21 | |||
| JP2000053649A | 2000-02-22 |
Other References:
MONTALIBET, JACQUELINE ET AL.: "Residues Distant from the Active Site Influence Protein-tyrosine Phosphatase 1B Inhibitor Binding", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, no. 8, 2006, pages 5258 - 5266
WIESMANN, CHRISTIAN ET AL.: "Allosteric inhibition of protein tyrosine phosphatase 1B", NATURE STRUCTURAL & MOLECULAR BIOLOGY, vol. 11, no. 8, 2004, pages 730 - 737
LIU, DING-GUO ET AL.: "Acylsulfonamide- containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 18, 2003, pages 3005 - 3007
WIESMANN, CHRISTIAN ET AL.: "Allosteric inhibition of protein tyrosine phosphatase 1B", NATURE STRUCTURAL & MOLECULAR BIOLOGY, vol. 11, no. 8, 2004, pages 730 - 737
LIU, DING-GUO ET AL.: "Acylsulfonamide- containing PTP1B inhibitors designed to mimic an enzyme-bound water of hydration", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 18, 2003, pages 3005 - 3007
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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