Title:
THERAPEUTIC AGENT FOR DIASTOLIC HEART FAILURE
Document Type and Number:
WIPO Patent Application WO/2012/011572
Kind Code:
A1
Abstract:
It has been discovered that carnitine, a derivative thereof or a pharmaceutically acceptable salt thereof is useful as an active ingredient of a prophylactic or therapeutic agent for diastolic heart failure. The present invention is capable of providing a pharmaceutical agent that is effective for prophylaxis or treatment of diastolic heart failure, on which an effective therapeutic method has not been established yet.
Inventors:
YAMAMOTO KAZUHIRO (JP)
MANO TOSHIAKI (JP)
SAKATA YASUSHI (JP)
OMORI YOSUKE (JP)
SOGA TOMOYOSHI (JP)
OHTANI TOMOHITO (JP)
MANO TOSHIAKI (JP)
SAKATA YASUSHI (JP)
OMORI YOSUKE (JP)
SOGA TOMOYOSHI (JP)
OHTANI TOMOHITO (JP)
Application Number:
PCT/JP2011/066707
Publication Date:
January 26, 2012
Filing Date:
July 22, 2011
Export Citation:
Assignee:
UNIV OSAKA (JP)
YAMAMOTO KAZUHIRO (JP)
MANO TOSHIAKI (JP)
SAKATA YASUSHI (JP)
OMORI YOSUKE (JP)
SOGA TOMOYOSHI (JP)
OHTANI TOMOHITO (JP)
YAMAMOTO KAZUHIRO (JP)
MANO TOSHIAKI (JP)
SAKATA YASUSHI (JP)
OMORI YOSUKE (JP)
SOGA TOMOYOSHI (JP)
OHTANI TOMOHITO (JP)
International Classes:
A61K31/205; A61K31/221; A61P9/00; A61P9/04; A61P21/00; A61P43/00
Foreign References:
| JPS59222412A | 1984-12-14 | |||
| JPS62190190A | 1987-08-20 | |||
| JPS62272984A | 1987-11-27 | |||
| JP2002518437A | 2002-06-25 |
Other References:
SERATI, A.R. ET AL.: "L-carnitine treatment in patients with mild diastolic heart failure is associated with improvement in diastolic function and symptoms", CARDIOLOGY, vol. 116, 21 January 2010 (2010-01-21), pages 178 - 182
KOBAYASHI, A. ET AL.: "Effects of L-carnitine on ventricular arrhythmias after coronary reperfusion", JPN. CIR. J., vol. 47, 1983, pages 536 - 542
CUI, J. ET AL.: "Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts", MOL. CELL. BIOCHEM., vol. 254, 2003, pages 227 - 234
CHAO, H.H. ET AL.: "L-carnitine attenuates angiotensin 11-induced proliferation of cardiac fibroblasts: role of NADPH oxidase inhibition and decreased sphingosine-1-phosphate generation", J. NUTRI. BIOCHEM., vol. 21, no. 7, July 2010 (2010-07-01), pages 580 - 588
BOEYNAEMS, J.M. ET AL.: "Palmitoyl-L-carnitine increases the release of prostacyclin from vascular endothelial cells", BIOCHEM. PHARMACOL., vol. 38, no. 19, 1989, pages 3261 - 3266, XP025541354, DOI: doi:10.1016/0006-2952(89)90623-0
ELLIOTT, G.R. ET AL.: "The effect of acute feeding of carnitine, acetyl carnitine and propionyl carnitine on basal and A23187- stimulated eicosanoid release from rat carrageenan-elicited peritoneal macrophages", BRI. J. NUTRI., vol. 64, 1990, pages 497 - 503
PAULY, D.F. ET AL.: "The role of carnitine in myocardial dysfunction", AM. J. KIDNEY DISEASE, vol. 41, no. 4, 2003, pages S35 - S43
JEEJEEBHOY, F. ET AL.: "Nutritional supplementation with myovive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction", AMERICAN HEART JOURNAL, vol. 143, no. 6, 2002, pages 1092 - 1100, XP029482820, DOI: doi:10.1067/mhj.2002.121927
ILEICETO, S. ET AL.: "Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infraction: the L-carnitine ecocardiografia digitalizzata infarto miocardico(CEDIM) trial", J. AM. COLL. CARDIOL., vol. 26, no. 2, 1995, pages 380 - 387, XP002290008, DOI: doi:10.1016/0735-1097(95)80010-E
KAZUHIRO YAMAMOTO: "Kakucho Fuzen ni yoru Mansei Shinfuzen", KOKYU TO JUNKAN, vol. 50, no. 4, 2002, pages 407 - 411
KOBAYASHI, A. ET AL.: "Effects of L-carnitine on ventricular arrhythmias after coronary reperfusion", JPN. CIR. J., vol. 47, 1983, pages 536 - 542
CUI, J. ET AL.: "Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts", MOL. CELL. BIOCHEM., vol. 254, 2003, pages 227 - 234
CHAO, H.H. ET AL.: "L-carnitine attenuates angiotensin 11-induced proliferation of cardiac fibroblasts: role of NADPH oxidase inhibition and decreased sphingosine-1-phosphate generation", J. NUTRI. BIOCHEM., vol. 21, no. 7, July 2010 (2010-07-01), pages 580 - 588
BOEYNAEMS, J.M. ET AL.: "Palmitoyl-L-carnitine increases the release of prostacyclin from vascular endothelial cells", BIOCHEM. PHARMACOL., vol. 38, no. 19, 1989, pages 3261 - 3266, XP025541354, DOI: doi:10.1016/0006-2952(89)90623-0
ELLIOTT, G.R. ET AL.: "The effect of acute feeding of carnitine, acetyl carnitine and propionyl carnitine on basal and A23187- stimulated eicosanoid release from rat carrageenan-elicited peritoneal macrophages", BRI. J. NUTRI., vol. 64, 1990, pages 497 - 503
PAULY, D.F. ET AL.: "The role of carnitine in myocardial dysfunction", AM. J. KIDNEY DISEASE, vol. 41, no. 4, 2003, pages S35 - S43
JEEJEEBHOY, F. ET AL.: "Nutritional supplementation with myovive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction", AMERICAN HEART JOURNAL, vol. 143, no. 6, 2002, pages 1092 - 1100, XP029482820, DOI: doi:10.1067/mhj.2002.121927
ILEICETO, S. ET AL.: "Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infraction: the L-carnitine ecocardiografia digitalizzata infarto miocardico(CEDIM) trial", J. AM. COLL. CARDIOL., vol. 26, no. 2, 1995, pages 380 - 387, XP002290008, DOI: doi:10.1016/0735-1097(95)80010-E
KAZUHIRO YAMAMOTO: "Kakucho Fuzen ni yoru Mansei Shinfuzen", KOKYU TO JUNKAN, vol. 50, no. 4, 2002, pages 407 - 411
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
Tatsu Iwatani (JP)
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