Title:
THERAPEUTIC AGENT FOR DILATED CARDIOMYOPATHY
Document Type and Number:
WIPO Patent Application WO/2018/225440
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a therapeutic agent for dilated cardiomyopathy disease which produces excellent effects in the treatment of dilated cardiomyopathy (DCM) and provides a given benefit to a large number of patients. The present invention is a therapeutic agent for dilated cardiomyopathy comprising at least one selected from the group consisting of mesenchymal stem cell and fine particles derived from the mesenchymal stem cell. It is preferable that the mesenchymal stem cell is a cell having the ability to contain or secrete fine particles, that the fine particles have an average particle size of 1000 nm or less, and that they are exosomes.
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Inventors:
SAWA YOSHIKI (JP)
MIYAGAWA SHIGERU (JP)
KAJITA DAISUKE (JP)
KURATA HAYATO (JP)
TAMADA KOTOE (JP)
NISHIDA HIROYUKI (JP)
MIYAGAWA SHIGERU (JP)
KAJITA DAISUKE (JP)
KURATA HAYATO (JP)
TAMADA KOTOE (JP)
NISHIDA HIROYUKI (JP)
Application Number:
PCT/JP2018/017807
Publication Date:
December 13, 2018
Filing Date:
May 08, 2018
Export Citation:
Assignee:
UNIV OSAKA (JP)
ROHTO PHARMA (JP)
ROHTO PHARMA (JP)
International Classes:
A61K35/28; A61K35/35; A61K35/51; A61K38/17; A61P9/04
Domestic Patent References:
| WO2015076717A2 | 2015-05-28 | |||
| WO2016094932A1 | 2016-06-23 | |||
| WO2007058308A1 | 2007-05-24 |
Foreign References:
| JP2005035945A | 2005-02-10 | |||
| JP2002506831A | 2002-03-05 | |||
| JP2000508911A | 2000-07-18 | |||
| JP2012157263A | 2012-08-23 | |||
| JP2012508733A | 2012-04-12 | |||
| US6777231B1 | 2004-08-17 |
Other References:
SAHOO, S. ET AL.: "Exosomes and cardiac repair after myocardial infarction", CIRC RES., vol. 114, no. 2, 2014, pages 333 - 344, XP055554390, ISSN: 0009-7330
ZHANG, H. ET AL.: "Inhibition of myocardial ischemia/reperfusion injury by exosomes secreted from mesenchymal stem cells", STEM CELL INT., vol. 2016, 2016, pages 1 - 8, XP055554411, ISSN: 1687-966X
LAI, RC. ET AL.: "Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury", STEM CELL RES., vol. 4, 2010, pages 214 - 222, XP027054731, ISSN: 1873-5061
CHANG, YL. ET AL.: "Therapeutic potential of stem cells strategy for cardiovascular diseases", STEM CELL INT., vol. 2016, 2016, pages 1 - 10, XP055554414, ISSN: 1687-966X
LIANG, H. ET AL.: "Increased expression of pigment epithelium-derived factor in aged mesenchymal stem cells impairs their therapeutic efficacy for attenuating myocardial infarction injury", EUR HEART J., vol. 34, no. 22, 2 June 2013 (2013-06-02), pages 1681 - 1690, XP055082889, ISSN: 0195-668X
HITONOBU TOMOIKE, GUIDELINES FOR DIAGNOSIS AND TREATMENT OF CARDIOVASCULAR DISEASES, 2011
MOL. CELL BIOCHEM., vol. 387, 2014, pages 279 - 285
MED. SCI. MONIT. BASIC RES., vol. 14, 2013, pages 20 - 31
CIRC. J., vol. 69, 2005, pages 107 - 113
J. BIOCHEM., vol. 34, no. 2, 2003, pages 269 - 76
JCI, vol. 106, 2000, pages 655 - 662
PITTENGER F. M. ET AL., SCIENCE, vol. 284, 1999, pages 143 - 147
See also references of EP 3636271A4
ZHANG, H. ET AL.: "Inhibition of myocardial ischemia/reperfusion injury by exosomes secreted from mesenchymal stem cells", STEM CELL INT., vol. 2016, 2016, pages 1 - 8, XP055554411, ISSN: 1687-966X
LAI, RC. ET AL.: "Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury", STEM CELL RES., vol. 4, 2010, pages 214 - 222, XP027054731, ISSN: 1873-5061
CHANG, YL. ET AL.: "Therapeutic potential of stem cells strategy for cardiovascular diseases", STEM CELL INT., vol. 2016, 2016, pages 1 - 10, XP055554414, ISSN: 1687-966X
LIANG, H. ET AL.: "Increased expression of pigment epithelium-derived factor in aged mesenchymal stem cells impairs their therapeutic efficacy for attenuating myocardial infarction injury", EUR HEART J., vol. 34, no. 22, 2 June 2013 (2013-06-02), pages 1681 - 1690, XP055082889, ISSN: 0195-668X
HITONOBU TOMOIKE, GUIDELINES FOR DIAGNOSIS AND TREATMENT OF CARDIOVASCULAR DISEASES, 2011
MOL. CELL BIOCHEM., vol. 387, 2014, pages 279 - 285
MED. SCI. MONIT. BASIC RES., vol. 14, 2013, pages 20 - 31
CIRC. J., vol. 69, 2005, pages 107 - 113
J. BIOCHEM., vol. 34, no. 2, 2003, pages 269 - 76
JCI, vol. 106, 2000, pages 655 - 662
PITTENGER F. M. ET AL., SCIENCE, vol. 284, 1999, pages 143 - 147
See also references of EP 3636271A4
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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