Title:
THERAPEUTIC AGENT FOR ENDOTHELIAL DISORDER
Document Type and Number:
WIPO Patent Application WO/2003/087072
Kind Code:
A1
Abstract:
A preventive and/or therapeutic agent for sicknesses associated with endothelial disorder, sepsis, severe sepsis or septic shock and sicknesses associated with signals through TLR, which comprises as an active ingredient a 3-amino-1,2-benzisothiazole compound of the formula (I) or a derivative thereof: (I) wherein each of R1, R2, R3 and R4 represents hydrogen or a substituent.
Inventors:
FURUSAKO SHOJI (JP)
SATOH TSUTOMU (JP)
NAKAMURA MASAKI (JP)
MIZUNO MASASHI (JP)
MORI SADAO (JP)
SATOH TSUTOMU (JP)
NAKAMURA MASAKI (JP)
MIZUNO MASASHI (JP)
MORI SADAO (JP)
Application Number:
PCT/JP2003/004108
Publication Date:
October 23, 2003
Filing Date:
March 31, 2003
Export Citation:
Assignee:
MOCHIDA PHARM CO LTD (JP)
FURUSAKO SHOJI (JP)
SATOH TSUTOMU (JP)
NAKAMURA MASAKI (JP)
MIZUNO MASASHI (JP)
MORI SADAO (JP)
FURUSAKO SHOJI (JP)
SATOH TSUTOMU (JP)
NAKAMURA MASAKI (JP)
MIZUNO MASASHI (JP)
MORI SADAO (JP)
International Classes:
A61P7/08; A61P11/00; A61P29/00; A61P31/04; A61P37/06; A61P43/00; C07D275/04; (IPC1-7): C07D275/04; A61K31/425; A61K31/4439; A61P7/08; A61P11/00; A61P29/00; A61P31/04; A61P37/06; A61P43/00; C07D417/12
Domestic Patent References:
| WO1999014216A1 | 1999-03-25 | |||
| WO1999036069A1 | 1999-07-22 |
Foreign References:
| DE1670920A1 | 1971-04-01 | |||
| DE1174783B | 1964-07-30 | |||
| US3790587A | 1974-02-05 | |||
| JPS4538613B1 | 1970-12-05 | |||
| DE2803755A1 | 1979-08-02 | |||
| ZA6804111A | ||||
| EP0908457A1 | 1999-04-14 | |||
| JPH06220030A | 1994-08-09 | |||
| US3707364A | 1972-12-26 | |||
| JPS60132905A | 1985-07-16 | |||
| JPH11222435A | 1999-08-17 | |||
| JP2000262290A | 2000-09-26 |
Other References:
NAKAMURA T.: "An expedient synthesis of 3-amino-1,2-benzisothiazoles", SYNTHESIS, no. 8, 1997, pages 871 - 873, XP002968892
BOESHAGEN H.: "Disproportionations of diphenyl disulfides to 1,2-benzisothiazoles and ortho-substituted thiophenols with anchimeric distribution of amide, thioamide and amidine groups in the ortho position", PHOSPHORUS AND SULFUR AND THE RELATED ELEMENTS, vol. 17, no. 3, 1983, pages 325 - 329, XP002968894
BOESHAGEN H.: "Reduction of 3-amino-1,2-benzisothiazoles and 3-imino-1,2-benzisothiazolines to 2-mercaptobenzamidines, benzamidinium thiolates, or 1,2-benzothioquinone methides", LIEBIGS ANNALEN DER CHEMIE, vol. 1, 1982, pages 14 - 27, XP002968893
BECKE F.: "New synthesis of 1,2-benzisothiazoles", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 729, 1969, pages 146 - 151, XP002049609
GEIGER W.: "3-Amino-1,2-benzisothiazoles and 3-imino-1,2-benzisothiazolines", CHEMISCHE BERICHTE, vol. 102, no. 6, 1969, pages 1961 - 1975, XP002968895
BOESHAGEN H.: "Disproportionations of diphenyl disulfides to 1,2-benzisothiazoles and ortho-substituted thiophenols with anchimeric distribution of amide, thioamide and amidine groups in the ortho position", PHOSPHORUS AND SULFUR AND THE RELATED ELEMENTS, vol. 17, no. 3, 1983, pages 325 - 329, XP002968894
BOESHAGEN H.: "Reduction of 3-amino-1,2-benzisothiazoles and 3-imino-1,2-benzisothiazolines to 2-mercaptobenzamidines, benzamidinium thiolates, or 1,2-benzothioquinone methides", LIEBIGS ANNALEN DER CHEMIE, vol. 1, 1982, pages 14 - 27, XP002968893
BECKE F.: "New synthesis of 1,2-benzisothiazoles", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 729, 1969, pages 146 - 151, XP002049609
GEIGER W.: "3-Amino-1,2-benzisothiazoles and 3-imino-1,2-benzisothiazolines", CHEMISCHE BERICHTE, vol. 102, no. 6, 1969, pages 1961 - 1975, XP002968895
Attorney, Agent or Firm:
Watanabe, Mochitoshi (12-5 Iwamoto-cho 2-chom, Chiyoda-ku Tokyo, JP)
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