Title:
THERAPEUTIC AGENT FOR FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2019/022257
Kind Code:
A1
Abstract:
Disclosed is a phosphorylation inhibitor for SMAD2/3 proteins or a therapeutic agent for fibrosis which comprises, as an active ingredient, a nucleic acid suppressing the expression of NEK6 (NIMA-related serine/threonine kinase 6) gene.
Inventors:
NAKAO KAZUHISA (JP)
ISHIYAMA JUNICHI (JP)
ICHIKAWA WATARU (JP)
MASUI ATSUSHI (JP)
AKASAKA YUNIKE (JP)
TOYOFUKU HIDEKAZU (JP)
HONDA AYA (JP)
ISHIYAMA JUNICHI (JP)
ICHIKAWA WATARU (JP)
MASUI ATSUSHI (JP)
AKASAKA YUNIKE (JP)
TOYOFUKU HIDEKAZU (JP)
HONDA AYA (JP)
Application Number:
PCT/JP2018/028459
Publication Date:
January 31, 2019
Filing Date:
July 30, 2018
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
International Classes:
A61K31/713; A61K31/7088; A61K31/7105; A61K47/54; A61K48/00; A61P11/00; A61P43/00; C12N15/113
Domestic Patent References:
| WO2012017919A1 | 2012-02-09 | |||
| WO2012017919A1 | 2012-02-09 | |||
| WO2012005368A1 | 2012-01-12 | |||
| WO2012017919A1 | 2012-02-09 | |||
| WO2013027843A1 | 2013-02-28 | |||
| WO2016159374A1 | 2016-10-06 | |||
| WO2013027843A1 | 2013-02-28 |
Foreign References:
| US20040097441A1 | 2004-05-20 | |||
| US20040097441A1 | 2004-05-20 | |||
| US3687808A | 1972-08-29 |
Other References:
LIMBACH ET AL.: "Summary: the modified nucleosides of RNA", NUCLEIC ACIDS RES., vol. 22, 1994, pages 2183 - 2196, XP001152667
"Concise Encyclopedia Of Polymer Science And Engineering", 1990, JOHN WILEY & SONS, pages: 858 - 859
ENGLISCH ET AL.: "Angewandte Chemie", vol. 30, 1991, pages: 613
See also references of EP 3659609A4
"Concise Encyclopedia Of Polymer Science And Engineering", 1990, JOHN WILEY & SONS, pages: 858 - 859
ENGLISCH ET AL.: "Angewandte Chemie", vol. 30, 1991, pages: 613
See also references of EP 3659609A4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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