Title:
THERAPEUTIC AGENT FOR FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2022/264456
Kind Code:
A1
Abstract:
This substance, which specifically binds to the PEX domain (hemopexin domain) of MT1-MMP (MMP-14) and inhibits a MT1-MMP-mediated survival signal to active hepatic stellate cells (aHSCs), can reduce or kill the active hepatic stellate cells (aHSCs) and can thus treat tissue fibrosis developed in the liver, etc.
Inventors:
NIITSU YOSHIRO (JP)
Application Number:
PCT/JP2021/047070
Publication Date:
December 22, 2022
Filing Date:
December 20, 2021
Export Citation:
Assignee:
NIITSU YOSHIRO (JP)
International Classes:
A61K31/166; A61K45/00; A61P1/16; A61P43/00
Other References:
NAOKO KUBO BIRUKAWA, KAZUYUKI MURASE, YASUSHI SATO, AKEMI KOSAKA, AKIHIRO YONEDA, HIROKI NISHITA, RYOSUKE FUJITA, MIYUKI NISHIMURA: "Activated Hepatic Stellate Cells Are Dependent on Self-collagen, Cleaved by Membrane Type 1 Matrix Metalloproteinase for Their Growth", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 289, no. 29, 18 July 2014 (2014-07-18), US , pages 20209 - 20221, XP055427098, ISSN: 0021-9258, DOI: 10.1074/jbc.M113.544494
KEI MATSUMOTO : "P-370 Investigation of the relationship between Epithelial mesenchymal transition (EMT) and matrix metalloproteinase 14 (MMP14) in renal fibrosis", JOURNAL OF THE JAPANESE SOCIETY OF NEPHROLOGY, vol. 60, no. 3, 1 January 2018 (2018-01-01), JP , pages 434, XP009542201, ISSN: 0385-2385
A. G. REMACLE, V. S. GOLUBKOV, S. A. SHIRYAEV, R. DAHL, J. L. STEBBINS, A. V. CHERNOV, A. V. CHELTSOV, M. PELLECCHIA, A. Y. STRONG: "Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth", CANCER RESEARCH, vol. 72, no. 9, 1 May 2012 (2012-05-01), US, pages 2339 - 2349, XP055239324, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-11-4149
REMACLE ALBERT G., SHIRYAEV SERGEY A., RADICHEV ILIAN A., ROZANOV DMITRI V., STEC BOGUSLAW, STRONGIN ALEX Y.: "Dynamic Interdomain Interactions Contribute to the Inhibition of Matrix Metalloproteinases by Tissue Inhibitors of Metalloproteinases", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 23, 1 June 2011 (2011-06-01), US , pages 21002 - 21012, XP093015466, ISSN: 0021-9258, DOI: 10.1074/jbc.M110.200139
KEI MATSUMOTO : "P-370 Investigation of the relationship between Epithelial mesenchymal transition (EMT) and matrix metalloproteinase 14 (MMP14) in renal fibrosis", JOURNAL OF THE JAPANESE SOCIETY OF NEPHROLOGY, vol. 60, no. 3, 1 January 2018 (2018-01-01), JP , pages 434, XP009542201, ISSN: 0385-2385
A. G. REMACLE, V. S. GOLUBKOV, S. A. SHIRYAEV, R. DAHL, J. L. STEBBINS, A. V. CHERNOV, A. V. CHELTSOV, M. PELLECCHIA, A. Y. STRONG: "Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth", CANCER RESEARCH, vol. 72, no. 9, 1 May 2012 (2012-05-01), US, pages 2339 - 2349, XP055239324, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-11-4149
REMACLE ALBERT G., SHIRYAEV SERGEY A., RADICHEV ILIAN A., ROZANOV DMITRI V., STEC BOGUSLAW, STRONGIN ALEX Y.: "Dynamic Interdomain Interactions Contribute to the Inhibition of Matrix Metalloproteinases by Tissue Inhibitors of Metalloproteinases", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 23, 1 June 2011 (2011-06-01), US , pages 21002 - 21012, XP093015466, ISSN: 0021-9258, DOI: 10.1074/jbc.M110.200139
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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