Title:
THERAPEUTIC AGENT FOR FIBROTIC DISEASES OF THE ORGANS
Document Type and Number:
WIPO Patent Application WO/2017/072816
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a therapeutic agent for fibrotic diseases of the organs that can effectively suppress (or prevent) organ fibrosis such as renal fibrosis. The present invention solves this problem by means of a therapeutic agent for fibrotic diseases of the organs that includes compounds represented by general formula (I), general formula (II), and general formula (III), and one or more compounds selected from the group consisting of pharmaceutically acceptable salts of the abovementioned compounds when R3 represents OH.
Inventors:
ABE TAKAAKI (JP)
HAYASHI KENICHIRO (JP)
HAYASHI KENICHIRO (JP)
Application Number:
PCT/JP2015/005455
Publication Date:
May 04, 2017
Filing Date:
October 29, 2015
Export Citation:
Assignee:
UNIV TOHOKU (JP)
KAKE EDUCATIONAL INST (JP)
KAKE EDUCATIONAL INST (JP)
International Classes:
A61K31/405; A61K31/192; A61P1/00; A61P1/16; A61P1/18; A61P9/00; A61P11/00; A61P13/12; A61P17/00; A61P19/00; A61P25/00; A61P43/00
Domestic Patent References:
| WO2014080640A1 | 2014-05-30 | |||
| WO2000044743A1 | 2000-08-03 |
Foreign References:
| JP2015189670A | 2015-11-02 |
Other References:
GENG ET AL.: "Erythropoietin ameliorates renal interstitial fibrosis via the inhibition of fibrocyte accumulation", MOLECULAR MEDICINE REPORTS, vol. 11, no. 5, May 2015 (2015-05-01), pages 3860 - 3865, XP055379531, ISSN: 1791-2997
PARK ET AL.: "Erythropoietin decreases renal fibrosis in mice with ureteral obstruction: role of inhibiting TGF-beta-induced epithelial-to- mesenchymal transition", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 18, no. 5, 2007, pages 1497 - 1507, XP055379533, ISSN: 1046-6673
GOBE ET AL.: "Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 306, no. 3, 15 March 2014 (2014-03-15), pages F681 - F692, XP055379538, ISSN: 0002-9513
PARK ET AL.: "Erythropoietin decreases renal fibrosis in mice with ureteral obstruction: role of inhibiting TGF-beta-induced epithelial-to- mesenchymal transition", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 18, no. 5, 2007, pages 1497 - 1507, XP055379533, ISSN: 1046-6673
GOBE ET AL.: "Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 306, no. 3, 15 March 2014 (2014-03-15), pages F681 - F692, XP055379538, ISSN: 0002-9513
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
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