Title:
THERAPEUTIC AGENT FOR HEPATITIS C
Document Type and Number:
WIPO Patent Application WO/2011/093483
Kind Code:
A1
Abstract:
Provided is a therapeutic agent for hepatitis C. A compound that has anti-HCV activity, which is useful in the treatment of hepatitis C, is an active ingredient of said agent. Said compound is the compound represented by formula (I) or a pharmacologically-permitted salt thereof.
Inventors:
BABA MASANORI (JP)
HASHIMOTO YUICHI (JP)
AOYAMA HIROSHI (JP)
SUGITA KAZUYUKI (JP)
NAKAMURA MASAHIKO (JP)
AOYAMA ATSUSHI (JP)
URATA YASUO (JP)
HASHIMOTO YUICHI (JP)
AOYAMA HIROSHI (JP)
SUGITA KAZUYUKI (JP)
NAKAMURA MASAHIKO (JP)
AOYAMA ATSUSHI (JP)
URATA YASUO (JP)
Application Number:
PCT/JP2011/051859
Publication Date:
August 04, 2011
Filing Date:
January 31, 2011
Export Citation:
Assignee:
UNIV KAGOSHIMA (JP)
ONCOLYS BIOPHARMA INC (JP)
BABA MASANORI (JP)
HASHIMOTO YUICHI (JP)
AOYAMA HIROSHI (JP)
SUGITA KAZUYUKI (JP)
NAKAMURA MASAHIKO (JP)
AOYAMA ATSUSHI (JP)
URATA YASUO (JP)
ONCOLYS BIOPHARMA INC (JP)
BABA MASANORI (JP)
HASHIMOTO YUICHI (JP)
AOYAMA HIROSHI (JP)
SUGITA KAZUYUKI (JP)
NAKAMURA MASAHIKO (JP)
AOYAMA ATSUSHI (JP)
URATA YASUO (JP)
International Classes:
A61K31/473; C07D221/12; A61P31/14
Domestic Patent References:
| WO1994018197A1 | 1994-08-18 |
Foreign References:
| JP2010500328A | 2010-01-07 | |||
| JP2010020502A | 2010-01-28 |
Other References:
AOYAMA, A.: "LXR Antagonists with a 5-Substituted Phenanthridin-6-one Skeleton: Synthesis and LXR Transrepression Activities of Conformationally Restricted Carba-T0901317 Analogs", HETEROCYCLES, vol. 76, no. 1, 2008, pages 137 - 142
COOKSON, R. F.: "Synthesis of Some Phenanthridone Derivatives", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 9, no. 3, 1972, pages 475 - 480
IWASAKI, H.: "Samarium(II)-Mediated Spirocyclization by Intramolecular Aryl Radical Addition onto an Aromatic Ring", JOURNAL OF ORGANIC CHEMISTRY, vol. 73, no. 18, 2008, pages 7145 - 7152
MAKOTO NAKAMUTA: "C-gata Kan'en Kan ni Okeru LXRa ni yoru Men'eki Kaihi Kiko no Kento", JAPANESE JOURNAL OF GASTROENTEROLOGY, 2008, pages 105
NAKAMURA, M. ET AL.: "Structural development studies of anti-hepatitis C virus agents with a phenanthridinone skeleton", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, no. 7, 2010, pages 2402 - 2411
CEDRON, J. C.: "Synthesis and antiplasmodial activity of lycorine derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, no. 13, 2010, pages 4694 - 4701
FURUTA, T.: "Synthesis of Axially Chiral Amino Acid and Amino Alcohols via Additive-Ligand- Free Pd-Catalyzed Domino Coupling Reaction and Subsequent Transformations of the Product Amidoaza[5]helicene", JOURNAL OF ORGANIC CHEMISTRY, vol. 75, no. 20, 2010, pages 7010 - 7013
LIANG, T.J.; REHERMANN, B.; SEEFF, L.B.; HOOFNAGLE, J.H.: "Pathogenesis, natural history, treatment and prevention of hepatitis C.", ANN. INTERN. MED., vol. 132, 2000, pages 296 - 305
KIM, S.R.; KUDO, M.; HINO, O.; HAN, K.H.; CHUNG, Y.H.; LEE, H.S.: "Organizing Committee of Japan-Korea Liver Symposium, Epidemiology of hepatocellular carcinoma in Japan and Korea", ONCOLOGY, vol. 75, no. 1, 2008, pages 13 - 16
HAYASHI, N.; TAKEHARA, T.: "Antiviral therapy for chronic hepatitis C: past, present, and future.", J. GASTROENTEROL., vol. 41, 2006, pages 17 - 27
MANNS, M.P.; FOSTER, G.R.; ROCKSTROH, J.K.; ZEUZEM, S.; ZOULIM, F.; HOUGHTON, M.: "The way forward in HCV treatment - finding the right path", NAT. REV. DRUG, vol. 6, 2007, pages 991 - 1000
KRONENBERGER, B.; WELSCH, C.; FORESTIER, N.; ZEUZEM, S.: "Novel hepatitis C drugs in current trials", CLIN LIVER DIS., vol. 12, 2008, pages 529 - 555
HCV EXPERIMENTAL TREATMENT., Retrieved from the Internet>
ISHII, N.; WATASHI, K.; HISHIKI, T.; GOTO, K.; INOUE, D.; HIJIKATA, M.; WAKITA, T.; KATO, N.; SHIMOTOHNO, K.: "Diverse effects of cyclosporine on hepatitis C virus strain replication.", J. VIROL., vol. 80, 2006, pages 4510 - 4520
NOBUYUKI KATO, VIRUS, vol. 52, no. 1, 2002, pages 157 - 162
AOYAMA, A. ET AL., HETEROCYCLES, vol. 76, 2008, pages 137 - 142
AOYAMA ET AL., HETEROCYCLES, vol. 76, no. 1, 2008, pages 137 - 142
ISHII ET AL., J. VIROL., vol. 80, 2006, pages 4510 - 4520
GOTO ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 343, 2006, pages 879 - 884
See also references of EP 2532652A4
COOKSON, R. F.: "Synthesis of Some Phenanthridone Derivatives", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 9, no. 3, 1972, pages 475 - 480
IWASAKI, H.: "Samarium(II)-Mediated Spirocyclization by Intramolecular Aryl Radical Addition onto an Aromatic Ring", JOURNAL OF ORGANIC CHEMISTRY, vol. 73, no. 18, 2008, pages 7145 - 7152
MAKOTO NAKAMUTA: "C-gata Kan'en Kan ni Okeru LXRa ni yoru Men'eki Kaihi Kiko no Kento", JAPANESE JOURNAL OF GASTROENTEROLOGY, 2008, pages 105
NAKAMURA, M. ET AL.: "Structural development studies of anti-hepatitis C virus agents with a phenanthridinone skeleton", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, no. 7, 2010, pages 2402 - 2411
CEDRON, J. C.: "Synthesis and antiplasmodial activity of lycorine derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18, no. 13, 2010, pages 4694 - 4701
FURUTA, T.: "Synthesis of Axially Chiral Amino Acid and Amino Alcohols via Additive-Ligand- Free Pd-Catalyzed Domino Coupling Reaction and Subsequent Transformations of the Product Amidoaza[5]helicene", JOURNAL OF ORGANIC CHEMISTRY, vol. 75, no. 20, 2010, pages 7010 - 7013
LIANG, T.J.; REHERMANN, B.; SEEFF, L.B.; HOOFNAGLE, J.H.: "Pathogenesis, natural history, treatment and prevention of hepatitis C.", ANN. INTERN. MED., vol. 132, 2000, pages 296 - 305
KIM, S.R.; KUDO, M.; HINO, O.; HAN, K.H.; CHUNG, Y.H.; LEE, H.S.: "Organizing Committee of Japan-Korea Liver Symposium, Epidemiology of hepatocellular carcinoma in Japan and Korea", ONCOLOGY, vol. 75, no. 1, 2008, pages 13 - 16
HAYASHI, N.; TAKEHARA, T.: "Antiviral therapy for chronic hepatitis C: past, present, and future.", J. GASTROENTEROL., vol. 41, 2006, pages 17 - 27
MANNS, M.P.; FOSTER, G.R.; ROCKSTROH, J.K.; ZEUZEM, S.; ZOULIM, F.; HOUGHTON, M.: "The way forward in HCV treatment - finding the right path", NAT. REV. DRUG, vol. 6, 2007, pages 991 - 1000
KRONENBERGER, B.; WELSCH, C.; FORESTIER, N.; ZEUZEM, S.: "Novel hepatitis C drugs in current trials", CLIN LIVER DIS., vol. 12, 2008, pages 529 - 555
HCV EXPERIMENTAL TREATMENT., Retrieved from the Internet
ISHII, N.; WATASHI, K.; HISHIKI, T.; GOTO, K.; INOUE, D.; HIJIKATA, M.; WAKITA, T.; KATO, N.; SHIMOTOHNO, K.: "Diverse effects of cyclosporine on hepatitis C virus strain replication.", J. VIROL., vol. 80, 2006, pages 4510 - 4520
NOBUYUKI KATO, VIRUS, vol. 52, no. 1, 2002, pages 157 - 162
AOYAMA, A. ET AL., HETEROCYCLES, vol. 76, 2008, pages 137 - 142
AOYAMA ET AL., HETEROCYCLES, vol. 76, no. 1, 2008, pages 137 - 142
ISHII ET AL., J. VIROL., vol. 80, 2006, pages 4510 - 4520
GOTO ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 343, 2006, pages 879 - 884
See also references of EP 2532652A4
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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