Title:
THERAPEUTIC AGENT FOR HIV INFECTION
Document Type and Number:
WIPO Patent Application WO/2022/186391
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition for use in the reactivation of HIV latent infection, the pharmaceutical composition containing compounds represented by formulae (I)-(VII).
Inventors:
MISUMI SHOGO (JP)
TSUKAMOTO SACHIKO (JP)
KISHIMOTO NAOKI (JP)
HITORA YUKI (JP)
MAEDA KENJI (JP)
TSUKAMOTO SACHIKO (JP)
KISHIMOTO NAOKI (JP)
HITORA YUKI (JP)
MAEDA KENJI (JP)
Application Number:
PCT/JP2022/009516
Publication Date:
September 09, 2022
Filing Date:
March 04, 2022
Export Citation:
Assignee:
UNIV KUMAMOTO NAT UNIV CORP (JP)
NAT CENTER FOR GLOBAL HEALTH AND MEDICINE (JP)
NAT CENTER FOR GLOBAL HEALTH AND MEDICINE (JP)
International Classes:
A61K31/225; A61K31/336; A61K45/00; A61P31/18; A61P43/00
Foreign References:
| CN110317209A | 2019-10-11 | |||
| JPH10287617A | 1998-10-27 | |||
| CN105198899A | 2015-12-30 |
Other References:
ASADA YOSHIHISA, SUKEMORI AYA, WATANABE TAKASHI, MALLA KUBER J., YOSHIKAWA TAKAFUMI, LI WEI, KUANG XINZHU, KOIKE KAZUO, CHEN CHIN-: "Isolation, Structure Determination, and Anti-HIV Evaluation of Tigliane-Type Diterpenes and Biflavonoid from Stellera chamaejasme", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 76, no. 5, 24 May 2013 (2013-05-24), US , pages 852 - 857, XP055964010, ISSN: 0163-3864, DOI: 10.1021/np300815t
OTSUKI KOUHARU, ZHANG MI, YAMAMOTO ASUKA, TSUJI MINAMI, TEJIMA MIYUKO, BAI ZI-SONG, ZHOU DI, HUANG LI, CHEN CHIN-HO, LEE KUO-HSIUN: "Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 83, no. 12, 24 December 2020 (2020-12-24), US , pages 3584 - 3590, XP055964011, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.0c00700
YAN MIN, LU YAN, CHEN CHIN-HO, ZHAO YU, LEE KUO-HSIUNG, CHEN DAO-FENG: "Stelleralides D–J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 78, no. 11, 25 November 2015 (2015-11-25), US , pages 2712 - 2718, XP055776312, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.5b00660
ASADA YOSHIHISA, SUKEMORI AYA, WATANABE TAKASHI, MALLA KUBER J., YOSHIKAWA TAKAFUMI, LI WEI, KOIKE KAZUO, CHEN CHIN-HO, AKIYAMA TO: "Stelleralides A–C, Novel Potent Anti-HIV Daphnane-Type Diterpenoids from Stellera chamaejasm e L.", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 11, 3 June 2011 (2011-06-03), US , pages 2904 - 2907, XP055964015, ISSN: 1523-7060, DOI: 10.1021/ol200889s
EGUCHI, KEISUKE ET AL.: "23T-pm08 Structure elucidation and activation of HIV LTR of gnidimacrin derivatives from Stellera chamaejasme L.", 139TH ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN; MARCH 20-23, 2019, vol. 139, 1 January 2019 (2019-01-01) - 23 March 2019 (2019-03-23), pages 23T - pm08, XP009539570
KISHIMOTO, NAOKI ET AL.: "O12-054: Search for HIV latent infection cell activator using Kumamoto University natural product library", THE JOURNAL OF AIDS RESEARCH, JAPANESE SOCIETY FOR AIDS RESEARCH, JP, vol. 21, no. 4, 1 January 2019 (2019-01-01), JP , pages 428, XP009539623, ISSN: 1344-9478
MATSUDA, KOUKI; MAEDA, KENJI: "In Vitro HIV Reservoir Analysis and the Development of Novel Therapeutics toward HIV Cure", THE JOURNAL OF AIDS RESEARCH, JAPANESE SOCIETY FOR AIDS RESEARCH, JP, vol. 21, no. 3, 30 August 2019 (2019-08-30), JP , pages 159 (33) - 166 (40), XP009539399, ISSN: 1344-9478
EGUCHI, KEISUKE; KATO, HIKARU; KISHIMOTO, NAOKI; MISUMI, SHOGO; WATANABE, TAKASHI; TSUKAMOTO, SACHIKO: "26P-pm248 Structure of new sesquiterpenes from Stellera chamaejasme L.", LECTURE ABSTRACTS OF THE 140TH ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN; KYOTO; MARCH 25-28, 2020, vol. 140, 5 March 2020 (2020-03-05) - 28 March 2020 (2020-03-28), pages 26P - pm248, XP009539571
MISUMI, SHOGO: "SY12-2 Reactivation of HIV latent infected cells using Kumamoto University natural product library", THE JOURNAL OF AIDS RESEARCH, JAPANESE SOCIETY FOR AIDS RESEARCH, JP, vol. 22, no. 4, 1 January 2020 (2020-01-01), JP , pages 346, XP009539398, ISSN: 1344-9478
LI SHI-FEI, LIANG XUE, WU XING-KANG, GAO XIANG, ZHANG LI-WEI: "Discovering the Mechanisms of Wikstroelide E as a Potential HIV-Latency-Reversing Agent by Transcriptome Profiling", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 84, no. 4, 23 April 2021 (2021-04-23), US , pages 1022 - 1033, XP055964017, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.0c01039
ZHANG MI, OTSUKI KOUHARU, KIKUCHI TAKASHI, BAI ZI-SONG, ZHOU DI, HUANG LI, CHEN CHIN-HO, MORRIS-NATSCHKE SUSAN L., LEE KUO-HSIUNG,: "LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from Wikstroemia lamatsoensis", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 84, no. 8, 27 August 2021 (2021-08-27), US , pages 2366 - 2373, XP055964016, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.1c00570
OTSUKI KOUHARU; ZHANG MI; KIKUCHI TAKASHI; TSUJI MINAMI; TEJIMA MIYUKO; BAI ZI-SONG; ZHOU DI; HUANG LI; CHEN CHIN-HO; LEE KUO-HSIU: "Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC–MS analysis and phytochemical investigation", JOURNAL OF NATURAL MEDICINES, JAPANESE SOCIETY OF PHARMACOGNOSY, TOKYO., JP, vol. 75, no. 4, 21 July 2021 (2021-07-21), JP , pages 1058 - 1066, XP037549961, ISSN: 1340-3443, DOI: 10.1007/s11418-021-01551-9
OTSUKI KOUHARU, ZHANG MI, YAMAMOTO ASUKA, TSUJI MINAMI, TEJIMA MIYUKO, BAI ZI-SONG, ZHOU DI, HUANG LI, CHEN CHIN-HO, LEE KUO-HSIUN: "Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 83, no. 12, 24 December 2020 (2020-12-24), US , pages 3584 - 3590, XP055964011, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.0c00700
YAN MIN, LU YAN, CHEN CHIN-HO, ZHAO YU, LEE KUO-HSIUNG, CHEN DAO-FENG: "Stelleralides D–J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 78, no. 11, 25 November 2015 (2015-11-25), US , pages 2712 - 2718, XP055776312, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.5b00660
ASADA YOSHIHISA, SUKEMORI AYA, WATANABE TAKASHI, MALLA KUBER J., YOSHIKAWA TAKAFUMI, LI WEI, KOIKE KAZUO, CHEN CHIN-HO, AKIYAMA TO: "Stelleralides A–C, Novel Potent Anti-HIV Daphnane-Type Diterpenoids from Stellera chamaejasm e L.", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 13, no. 11, 3 June 2011 (2011-06-03), US , pages 2904 - 2907, XP055964015, ISSN: 1523-7060, DOI: 10.1021/ol200889s
EGUCHI, KEISUKE ET AL.: "23T-pm08 Structure elucidation and activation of HIV LTR of gnidimacrin derivatives from Stellera chamaejasme L.", 139TH ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN; MARCH 20-23, 2019, vol. 139, 1 January 2019 (2019-01-01) - 23 March 2019 (2019-03-23), pages 23T - pm08, XP009539570
KISHIMOTO, NAOKI ET AL.: "O12-054: Search for HIV latent infection cell activator using Kumamoto University natural product library", THE JOURNAL OF AIDS RESEARCH, JAPANESE SOCIETY FOR AIDS RESEARCH, JP, vol. 21, no. 4, 1 January 2019 (2019-01-01), JP , pages 428, XP009539623, ISSN: 1344-9478
MATSUDA, KOUKI; MAEDA, KENJI: "In Vitro HIV Reservoir Analysis and the Development of Novel Therapeutics toward HIV Cure", THE JOURNAL OF AIDS RESEARCH, JAPANESE SOCIETY FOR AIDS RESEARCH, JP, vol. 21, no. 3, 30 August 2019 (2019-08-30), JP , pages 159 (33) - 166 (40), XP009539399, ISSN: 1344-9478
EGUCHI, KEISUKE; KATO, HIKARU; KISHIMOTO, NAOKI; MISUMI, SHOGO; WATANABE, TAKASHI; TSUKAMOTO, SACHIKO: "26P-pm248 Structure of new sesquiterpenes from Stellera chamaejasme L.", LECTURE ABSTRACTS OF THE 140TH ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN; KYOTO; MARCH 25-28, 2020, vol. 140, 5 March 2020 (2020-03-05) - 28 March 2020 (2020-03-28), pages 26P - pm248, XP009539571
MISUMI, SHOGO: "SY12-2 Reactivation of HIV latent infected cells using Kumamoto University natural product library", THE JOURNAL OF AIDS RESEARCH, JAPANESE SOCIETY FOR AIDS RESEARCH, JP, vol. 22, no. 4, 1 January 2020 (2020-01-01), JP , pages 346, XP009539398, ISSN: 1344-9478
LI SHI-FEI, LIANG XUE, WU XING-KANG, GAO XIANG, ZHANG LI-WEI: "Discovering the Mechanisms of Wikstroelide E as a Potential HIV-Latency-Reversing Agent by Transcriptome Profiling", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 84, no. 4, 23 April 2021 (2021-04-23), US , pages 1022 - 1033, XP055964017, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.0c01039
ZHANG MI, OTSUKI KOUHARU, KIKUCHI TAKASHI, BAI ZI-SONG, ZHOU DI, HUANG LI, CHEN CHIN-HO, MORRIS-NATSCHKE SUSAN L., LEE KUO-HSIUNG,: "LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from Wikstroemia lamatsoensis", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 84, no. 8, 27 August 2021 (2021-08-27), US , pages 2366 - 2373, XP055964016, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.1c00570
OTSUKI KOUHARU; ZHANG MI; KIKUCHI TAKASHI; TSUJI MINAMI; TEJIMA MIYUKO; BAI ZI-SONG; ZHOU DI; HUANG LI; CHEN CHIN-HO; LEE KUO-HSIU: "Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC–MS analysis and phytochemical investigation", JOURNAL OF NATURAL MEDICINES, JAPANESE SOCIETY OF PHARMACOGNOSY, TOKYO., JP, vol. 75, no. 4, 21 July 2021 (2021-07-21), JP , pages 1058 - 1066, XP037549961, ISSN: 1340-3443, DOI: 10.1007/s11418-021-01551-9
Attorney, Agent or Firm:
YAMAMOTO, Osamu et al. (JP)
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