Title:
THERAPEUTIC AGENT FOR HYPERTENSION, METHOD FOR TREATING HYPERTENSION, METHOD FOR DIAGNOSING HYPERTENSION, AND METHOD FOR SCREENING THERAPEUTIC AGENT FOR HYPERTENSION
Document Type and Number:
WIPO Patent Application WO/2010/067755
Kind Code:
A1
Abstract:
Disclosed are a therapeutic agent for hypertension and others, which can be developed by studying a gene that is involved in circadian rhythm and causes hypertension. The therapeutic agent for hypertension comprises, as an active ingredient, the following specific substance: the specific substance can affect the expression of at least one gene selected from a first gene which is involved in the circadian rhythm in the adrenal cortex, a second gene which is affected by the behavior of the first gene and is involved in the production of adrenal cortex hormone, and a third gene which is involved in the signaling between the first gene and the second gene, or the specific substance can affect the activity of a product of the gene. It is confirmed that a blood pressure changes when the specific substance is administered. The therapeutic agent for hypertension can be screened utilizing a specific cell which contains the first gene, the second gene or the third gene.
Inventors:
OKAMURA HITOSHI (JP)
DOI MASAO (JP)
DOI MASAO (JP)
Application Number:
PCT/JP2009/070346
Publication Date:
June 17, 2010
Filing Date:
December 03, 2009
Export Citation:
Assignee:
OKAMURA HITOSHI (JP)
PHARMAFRONTIER CO LTD (JP)
DOI MASAO (JP)
PHARMAFRONTIER CO LTD (JP)
DOI MASAO (JP)
International Classes:
A61K45/00; A61K48/00; A61P9/12; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50
Other References:
SHUICHI SHIGETOMI ET AL.: "Primary Aldosteronism Oyobi Hontaisei Koketsuatsusho ni Taisuru beta-hydroxysteroid dehydrogenase Sogaizai (Trilostane) no Koka", NAIKA, vol. 50, no. 2, 1982, pages 357 - 361
SHUICHI SHIGETOMI ET AL.: "Primary Aldosteronism ni Taisuru Trilostane(MWD-1822) no Koka", FOLIA ENDOCRINOLOGICA JAPONICA, vol. 58, no. 3, 1982, pages 184 - 198
ROSMOND R. ET AL.: "Polymorphism in exon 4 of the human 3beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure", BIOCHEM BIOPHYS RES COMMUN, vol. 293, no. 1, 2002, pages 629 - 632
NORIYUKI KATSUMATA: "Tokushu Ketsuatsu Chosetsu to Hormone Sentensei Fukujin Kakeiseisho to Ketsuatsu", ENDOCRINOLOGY & DIABETOLOGY, vol. 19, no. 1, 2004, pages 36 - 39
TAKAHIRO MORIYA ET AL.: "Tokei Idenshi no Kanten kara no Ketsuatsu Nichinai Rhythm Ijo to Yakubutsu Koka no Bunshi Seibutsugakuteki Kaiseki", RECENT ADVANCES IN CLINICAL PHARMACOLOGY, 2005, pages 85 - 94
MASUKI SHIZUE ET AL.: "Reduced a-adrenoceptor responsiveness and enhanced baroreflex sensitivity in Cry-deficient mice lacking a biological clock", JOURNAL OF PHYSIOLOGY (OXFORD, UNITED KINGDOM), vol. 566, no. 1, 2005, pages 213 - 224
TANIDA MAMORU ET AL.: "Autonomic and cardiovascular responses to scent stimulation are altered in cry KO mice", NEUROSCIENCE LETTERS, vol. 413, no. 2, 2007, pages 177 - 182
SHUICHI SHIGETOMI ET AL.: "Primary Aldosteronism ni Taisuru Trilostane(MWD-1822) no Koka", FOLIA ENDOCRINOLOGICA JAPONICA, vol. 58, no. 3, 1982, pages 184 - 198
ROSMOND R. ET AL.: "Polymorphism in exon 4 of the human 3beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure", BIOCHEM BIOPHYS RES COMMUN, vol. 293, no. 1, 2002, pages 629 - 632
NORIYUKI KATSUMATA: "Tokushu Ketsuatsu Chosetsu to Hormone Sentensei Fukujin Kakeiseisho to Ketsuatsu", ENDOCRINOLOGY & DIABETOLOGY, vol. 19, no. 1, 2004, pages 36 - 39
TAKAHIRO MORIYA ET AL.: "Tokei Idenshi no Kanten kara no Ketsuatsu Nichinai Rhythm Ijo to Yakubutsu Koka no Bunshi Seibutsugakuteki Kaiseki", RECENT ADVANCES IN CLINICAL PHARMACOLOGY, 2005, pages 85 - 94
MASUKI SHIZUE ET AL.: "Reduced a-adrenoceptor responsiveness and enhanced baroreflex sensitivity in Cry-deficient mice lacking a biological clock", JOURNAL OF PHYSIOLOGY (OXFORD, UNITED KINGDOM), vol. 566, no. 1, 2005, pages 213 - 224
TANIDA MAMORU ET AL.: "Autonomic and cardiovascular responses to scent stimulation are altered in cry KO mice", NEUROSCIENCE LETTERS, vol. 413, no. 2, 2007, pages 177 - 182
Attorney, Agent or Firm:
KAWASHIMA MASAAKI (JP)
Masaaki Kawashima (JP)
Masaaki Kawashima (JP)
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