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Title:
THERAPEUTIC AGENT FOR INTRACELLULAR TDP-43 CONTENT-RELATED DISEASE
Document Type and Number:
WIPO Patent Application WO/2017/111166
Kind Code:
A1
Abstract:
According to the present invention, a drug for treating an intracellular TDP-43 content-related disease is developed and provided . In the binding of TDP-43 to a specific mt-tRNA, the binding sites of the respective substances are identified. On the basis of the result of the identification, a binding inhibitor capable of selectively inhibiting the binding of TDP-43 to the specific mt-tRNA is developed.

Inventors:
IZUMIKAWA Keiichi (3-8-1 Harumi-cho, Fuchu-sh, Tokyo 38, 〒1838538, JP)
TAKAHASHI Nobuhiro (3-8-1 Harumi-cho, Fuchu-sh, Tokyo 38, 〒1838538, JP)
ISHIKAWA Hideaki (3-8-1 Harumi-cho, Fuchu-sh, Tokyo 38, 〒1838538, JP)
ISOBE Toshiaki (5-6-7, Minamino Hachioji-sh, Tokyo 16, 〒1920916, JP)
Application Number:
JP2016/088738
Publication Date:
June 29, 2017
Filing Date:
December 26, 2016
Export Citation:
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Assignee:
NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY (3-8-1, Harumi-cho Fuchu-sh, Tokyo 38, 〒1838538, JP)
TOKYO METROPOLITAN UNIVERSITY (3-1 Nishishinjuku 2-chome, Shinjuku-ku Tokyo, 26, 〒1630926, JP)
International Classes:
C12N15/09; A61K31/7105; A61K38/00; A61K45/00; A61K48/00; A61P21/02; A61P25/00; A61P25/16; A61P25/28; A61P43/00
Domestic Patent References:
2013-09-06
Foreign References:
JP2015505665A2015-02-26
Other References:
AYALA, Y. M. ET AL.: "Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function", J. MOL. BIOL., vol. 348, 2005, pages 575 - 588, XP004918552, DOI: doi:10.1016/j.jmb.2005.02.038
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (Atago Green Hills MORI Tower 32F, 5-1 Atago 2-chome, Minato-k, Tokyo 32, 〒1056232, JP)
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