THERAPEUTIC AGENT FOR ISCHEMIC DISEASES

WIPO Patent Application WO/2016/117508

A1

　Provided are: a transformation plasmid for transforming anaerobes and enabling highly efficient and stable secretory expression of a target protein; a gene delivery carrier formed from said anaerobes transformed by said plasmid; a pharmaceutical composition including said gene delivery carrier; and a method for diagnosing or treating an ischemic disease utilizing these.　Also provided are: a novel secretory signal; a transformation plasmid including said secretory signal; a gene delivery carrier formed from anaerobes transformed by said plasmid; a pharmaceutical composition including said gene delivery carrier; and a method for diagnosing or treating an ischemic disease utilizing these.

WADA YUKO (JP)
SHIMATANI YUKO (JP)
YANO TAKASHI (JP)
MASAKI TAKESHI (JP)

PCT/JP2016/051293

July 28, 2016

January 18, 2016

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UNIV SHINSHU (JP)
ANAEROPHARMA SCIENCE INC (JP)

C12N15/09; A61K35/74; A61K47/26; A61K48/00; A61P9/00; C12N1/21; C12Q1/02

WO2011093465A1	2011-08-04
WO2011093468A1	2011-08-04
WO2014010758A1	2014-01-16

FUJITA K. ET AL.: "Identification and molecular cloning of a novel glycoside hydrolase family of core 1 type O-glycan-specific endo-alpha-N- acetylgalactosaminidase from Bifidobacterium longum", J BIOL CHEM, vol. 280, no. 45, 2005, pages 37415 - 37422, XP002383896
DATABASE GenBank [O] 7 November 2005 (2005-11-07), XP055461414, Database accession no. AAX44931
DATABASE GenBank [O] 17 June 2013 (2013-06-17), XP055461422, Database accession no. EPE38071
See also references of EP 3249043A4

KUZUWA, Kiyoshi (JP)
Seiji Kuzuwa (JP)

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