THERAPEUTIC AGENT FOR KERATOCONJUNCTIVA DISORDER

Title:

THERAPEUTIC AGENT FOR KERATOCONJUNCTIVA DISORDER

Document Type and Number:

WIPO Patent Application WO/2006/030753

Kind Code:

A1

Abstract:

A new medicinal use of E-4-[4-(5-methyl-2phenyl-4-oxazolylmethoxy)benzyloxyimino]-4-phenylbutyric acid, Z-2-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyloxyimino]-2-(4-phenoxyphenyl)acetic acid, 2-[2-propyl-3[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic acid, 2(S)-methoxy-3-[4-[3-(4phenoxyphenoxy)propoxy]phenyl]propionic acid, or a salt of any of these. These carboxylic acid compounds and salts thereof each produces an excellent alleviating effect on corneal disorder models and is useful as a therapeutic agent for keratoconjunctiva disorders such as dry eye, corneal ulcer, keratitis, conjunctivitis, superficial punctate keratopathy, subepithelial corneal defects, subepithelial conjunctival defects, keratoconjunctivitis sicca, superior limbic keratoconjunctivitis, and filamentary keratitis.

Inventors:

NAKAMURA MASATSUGU (JP)
HIRAI SHIN-ICHIRO (JP)
SHIBAGAKI KEIICHI (JP)

Application Number:

PCT/JP2005/016788

Publication Date:

March 23, 2006

Filing Date:

September 13, 2005

Export Citation:

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Assignee:

SANTEN PHARMACEUTICAL CO LTD (JP)
NAKAMURA MASATSUGU (JP)
HIRAI SHIN-ICHIRO (JP)
SHIBAGAKI KEIICHI (JP)

International Classes:

A61K31/192; A61K31/421; A61K31/603; A61P27/02; A61P43/00; C07D263/32

Domestic Patent References:

WO2000000194A1	2000-01-06
WO2002100813A2	2002-12-19

Foreign References:

JP3074532B2	2000-08-07
JP3417582B2	2003-06-16

Other References:

SAKAMOTO J ET AL: "A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes.", EUR J PHARMACOL., vol. 495, July 2004 (2004-07-01), pages 17 - 26, XP002993871
See also references of EP 1790338A4

Attorney, Agent or Firm:

Hibi, Norihiko c/o KISHIMOTO & CO. (3rd Floor Inaba Building, 13-18, Nishishinsaibashi 1-chome, Chuo-k, Osaka-shi Osaka 86, JP)

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