Title:
THERAPEUTIC AGENT FOR LIVER DISEASE AND METHOD FOR TREATING LIVER DISEASE
Document Type and Number:
WIPO Patent Application WO/2017/110425
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel therapeutic agent for a liver disease. Provided is a therapeutic agent for liver disease that comprises microparticles derived from interstitial cells. The microparticles preferably have an average particle size of 1,000 nm or smaller. The therapeutic agent for a liver disease according to the present invention preferably comprises interstitial cells that contain the aforesaid microparticles or are capable of secreting the microparticles.
Inventors:
KURATA HAYATO (JP)
OCHIYA TAKAHIRO (JP)
OCHIYA TAKAHIRO (JP)
Application Number:
PCT/JP2016/085917
Publication Date:
June 29, 2017
Filing Date:
December 02, 2016
Export Citation:
Assignee:
ROHTO PHARMA (JP)
NAT CANCER CT (JP)
NAT CANCER CT (JP)
International Classes:
A61K35/35; A61K35/28; A61K38/00; A61P1/16; C07K14/475; C07K14/54; C12N5/077
Foreign References:
| JP2012056913A | 2012-03-22 | |||
| JP2012502934A | 2012-02-02 | |||
| CN101890050A | 2010-11-24 |
Other References:
LI, T. ET AL.: "Exosomes Dirived from Human Umbilical Cord Mesencymal Stem Cells Alleviate Liver Fibrosis", STEM CELLS AND DEVELOPMENT, vol. 22, no. 6, 2013, pages 845 - 854, XP055486470, ISSN: 1547-3287, DOI: doi:10.1089/scd.2012.0395
TAN, C. Y. ET AL.: "EXPLORING MESENCHYMAL STEM CELL DERIVED EXOSOME AS A HEPATOPROTECTIVE AGENT IN DRUG-INDUCED LIVER INJURY (DIALI", DRUG METAB REV, vol. 44, no. 1, 2012, pages 98, ISSN: 0360-2532
TAN, C. Y. ET AL.: "Mesenchymal stem cell -derived exosomes promote hepatic regeneration in drug-induced liver injury models", STEM CELL RES THER, vol. 5, no. 3, 10 June 2014 (2014-06-10), pages 76, XP021195493, ISSN: 1757-6512, DOI: doi:10.1186/scrt465
KO, S.F. ET AL.: "Adipose-Derived Mesenchymal Stem Cell Exosomes Suppress Hepatocellular Carcinoma Growth in a Rat Model: Apparent Diffusion Coefficient", NATURAL KILLER T- CELL RESPONSES, AND HISTOPATHOLOGICAL FEATURES, STEM CELLS INT, August 2015 (2015-08-01), pages 8 53506, XP055600123, ISSN: 1687-9678
TAN, C. Y. ET AL.: "EXPLORING MESENCHYMAL STEM CELL DERIVED EXOSOME AS A HEPATOPROTECTIVE AGENT IN DRUG-INDUCED LIVER INJURY (DIALI", DRUG METAB REV, vol. 44, no. 1, 2012, pages 98, ISSN: 0360-2532
TAN, C. Y. ET AL.: "Mesenchymal stem cell -derived exosomes promote hepatic regeneration in drug-induced liver injury models", STEM CELL RES THER, vol. 5, no. 3, 10 June 2014 (2014-06-10), pages 76, XP021195493, ISSN: 1757-6512, DOI: doi:10.1186/scrt465
KO, S.F. ET AL.: "Adipose-Derived Mesenchymal Stem Cell Exosomes Suppress Hepatocellular Carcinoma Growth in a Rat Model: Apparent Diffusion Coefficient", NATURAL KILLER T- CELL RESPONSES, AND HISTOPATHOLOGICAL FEATURES, STEM CELLS INT, August 2015 (2015-08-01), pages 8 53506, XP055600123, ISSN: 1687-9678
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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