Title:
THERAPEUTIC AGENT FOR MALIGNANT MESOTHELIOMA
Document Type and Number:
WIPO Patent Application WO/2008/013276
Kind Code:
A1
Abstract:
Disclosed is a therapeutic agent effective for malignant mesothelioma. Specifically disclosed is a therapeutic agent for mesothelioma, which comprises a calponin-targeting oncolytic herpes simplex virus (HSV-1) mutant, preferably strain d12.CALPfΔRR. Also disclosed is a method for producing a cell for use in the treatment of mesothelioma, which is characterized by infecting a mesothelioma cell removed from a patient with a herpes simplex virus F-type mutant which can proliferate in a calponin gene-targeting manner, preferably strain d12.CALPfΔRR. Further disclosed are: a cell produced by the method; and a calponin-targeting oncolytic herpes simplex virus (HSV-1) mutant, preferably strain d12.CALPfΔRR.
Inventors:
TAKAHASHI, Katsuhito (125-801, Aioi-cho Imadegawa-Agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto-sh, Kyoto 27, 6020827, JP)
高橋 克仁 (〒27 京都府京都市上京区河原町通今出川上る相生町１２５－８０１ Kyoto, 6020827, JP)
高橋 克仁 (〒27 京都府京都市上京区河原町通今出川上る相生町１２５－８０１ Kyoto, 6020827, JP)
Application Number:
JP2007/064798
Publication Date:
January 31, 2008
Filing Date:
July 27, 2007
Export Citation:
Assignee:
Japan Science and Technology Agency (1-8 Honcho 4-chome, Kawaguchi-shi Saitama, 12, 3320012, JP)
独立行政法人科学技術振興機構 (〒12 埼玉県川口市本町４丁目１番８号 Saitama, 3320012, JP)
TAKAHASHI, Katsuhito (125-801, Aioi-cho Imadegawa-Agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto-sh, Kyoto 27, 6020827, JP)
独立行政法人科学技術振興機構 (〒12 埼玉県川口市本町４丁目１番８号 Saitama, 3320012, JP)
TAKAHASHI, Katsuhito (125-801, Aioi-cho Imadegawa-Agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto-sh, Kyoto 27, 6020827, JP)
International Classes:
C12N7/00; A61K35/12; A61K35/76; A61P35/00; C12N5/10; C12R1/93
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (AOYAMA & PARTNERS, IMP Building 3-7, Shiromi 1-chome, Chuo-ku, Osaka-sh, Osaka 01, 5400001, JP)
Download PDF: