Title:
THERAPEUTIC AGENT FOR MESOTHELIOMA
Document Type and Number:
WIPO Patent Application WO/2005/037315
Kind Code:
A1
Abstract:
A therapeutic agent for mesothelioma, comprising an interleukin-6 (IL-6) antagonist, for example, an antibody against IL-6 receptor (IL-6R); and a mesothelioma cytostatic agent comprising an IL-6 antagonist, for example, an antibody against IL-6R.
Inventors:
NISHIMOTO NORIHIRO (JP)
KISHIMOTO TADAMITSU (JP)
ADACHI YASUO (JP)
TAKAYAMA KOICHI (JP)
KISHIMOTO TADAMITSU (JP)
ADACHI YASUO (JP)
TAKAYAMA KOICHI (JP)
Application Number:
PCT/JP2004/015674
Publication Date:
April 28, 2005
Filing Date:
October 15, 2004
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
NISHIMOTO NORIHIRO (JP)
KISHIMOTO TADAMITSU (JP)
ADACHI YASUO (JP)
TAKAYAMA KOICHI (JP)
NISHIMOTO NORIHIRO (JP)
KISHIMOTO TADAMITSU (JP)
ADACHI YASUO (JP)
TAKAYAMA KOICHI (JP)
International Classes:
A61K39/395; A61K45/06; C07K16/24; C07K16/28; (IPC1-7): A61K45/00; A61K39/395; A61P35/00
Domestic Patent References:
| WO2001042484A1 | 2001-06-14 | |||
| WO2001042484A1 | 2001-06-14 | |||
| WO1995009873A1 | 1995-04-13 | |||
| WO1992019759A1 | 1992-11-12 | |||
| WO1996018648A1 | 1996-06-20 | |||
| WO1996017869A2 | 1996-06-13 |
Foreign References:
| JPH08245414A | 1996-09-24 | |||
| JPH08245414A | 1996-09-24 | |||
| FR2694767A1 | 1994-02-18 | |||
| US0521628A | 1894-06-19 | |||
| JPH03219894A | 1991-09-27 | |||
| US5571513A | 1996-11-05 | |||
| JPH08291199A | 1996-11-05 | |||
| JPH02188600A | 1990-07-24 | |||
| JPH07324097A | 1995-12-12 | |||
| JPH08311098A | 1996-11-26 | |||
| US5210075A | 1993-05-11 |
Other References:
BIELEFELDT-OHMANN H. ET AL: "Interleukin-6 involvement in mesothelioma pathobiology: inhibition by interferon alpha alpha immunotherapy", 40, 1995, pages 241 - 250, XP002983492
SUZUKI H. ET AL: "Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo", EUR.J.IMMUNOL., vol. 22, 1992, pages 1989 - 1993, XP001021610
NAKANO T. ET AL: "Interleukin 6 and its relationship to clinical parameters in patients with malignant pleural mesothelioma", BRITSH JOURNAL OF CANCER, vol. 77, no. 6, 1998, pages 907 - 912, XP002983493
HIGASHIHARA M.D. ET AL: "Increased Secretion of Interleukin-6 in Malignant Mesothelioma Cells from a Patient with Marked Thrombocytosis", CANCER, vol. 70, no. 8, 1992, pages 2105 - 2108, XP002983494
HIGASHIHARA, CANCER, vol. 70, no. 8, 15 October 1992 (1992-10-15), pages 2105 - 2108
BIELEFELDT-OHMANN, CANCER IMMUNOL. IMMUNOTHER., vol. 40, 1995, pages 241 - 250
MONTI ET AL., CANCER RESEARCH, vol. 54, no. 16, 1994, pages 4419 - 4423
NAKA ET AL., ARTHRITIS RES, vol. 4, no. 3, 2002, pages S233 - S242
MIHARA ET AL., IMMUNOLOGY LETTERS, vol. 84, 2002, pages 223 - 229
SUZUKI ET AL., EUR. J. IMMUNOL., vol. 22, 1992, pages 1989 - 1993
TAKAGI: "Respiratory Diseases", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 1999, pages 469 - 472
NAKANO, RESPIRATION, vol. 18, no. 9, 1999, pages 916 - 925
TADA: "Respiratory Diseases", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 1999, pages 406 - 408
NAKANO: "Respiratory Diseases", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2003, pages 570 - 573
NOVICK, D. ET AL., HYBRIDOMA, vol. 10, 1991, pages 137 - 146
HUANG, Y.W. ET AL., HYBRIDOMA, vol. 12, 1993, pages 621 - 630
HIRATA, Y. ET AL., J. IMMUNOL., vol. 143, 1989, pages 2900 - 2906
VRIEND ET AL., J. MOL. GRAPHICS, vol. 8, 1990, pages 52 - 56
BRAKENHOFF ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 86 - 93
SAVINO ET AL., EMBO J., vol. 13, 1994, pages 1357 - 1367
SUZUKI H. ET AL: "Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo", EUR.J.IMMUNOL., vol. 22, 1992, pages 1989 - 1993, XP001021610
NAKANO T. ET AL: "Interleukin 6 and its relationship to clinical parameters in patients with malignant pleural mesothelioma", BRITSH JOURNAL OF CANCER, vol. 77, no. 6, 1998, pages 907 - 912, XP002983493
HIGASHIHARA M.D. ET AL: "Increased Secretion of Interleukin-6 in Malignant Mesothelioma Cells from a Patient with Marked Thrombocytosis", CANCER, vol. 70, no. 8, 1992, pages 2105 - 2108, XP002983494
HIGASHIHARA, CANCER, vol. 70, no. 8, 15 October 1992 (1992-10-15), pages 2105 - 2108
BIELEFELDT-OHMANN, CANCER IMMUNOL. IMMUNOTHER., vol. 40, 1995, pages 241 - 250
MONTI ET AL., CANCER RESEARCH, vol. 54, no. 16, 1994, pages 4419 - 4423
NAKA ET AL., ARTHRITIS RES, vol. 4, no. 3, 2002, pages S233 - S242
MIHARA ET AL., IMMUNOLOGY LETTERS, vol. 84, 2002, pages 223 - 229
SUZUKI ET AL., EUR. J. IMMUNOL., vol. 22, 1992, pages 1989 - 1993
TAKAGI: "Respiratory Diseases", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 1999, pages 469 - 472
NAKANO, RESPIRATION, vol. 18, no. 9, 1999, pages 916 - 925
TADA: "Respiratory Diseases", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 1999, pages 406 - 408
NAKANO: "Respiratory Diseases", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2003, pages 570 - 573
NOVICK, D. ET AL., HYBRIDOMA, vol. 10, 1991, pages 137 - 146
HUANG, Y.W. ET AL., HYBRIDOMA, vol. 12, 1993, pages 621 - 630
HIRATA, Y. ET AL., J. IMMUNOL., vol. 143, 1989, pages 2900 - 2906
VRIEND ET AL., J. MOL. GRAPHICS, vol. 8, 1990, pages 52 - 56
BRAKENHOFF ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 86 - 93
SAVINO ET AL., EMBO J., vol. 13, 1994, pages 1357 - 1367
Attorney, Agent or Firm:
Aoki, Atsushi (Ishida & Associates Toranomon 37 Mori
Bldg., 5-1, Toranomon 3-chom, Minato-ku Tokyo, JP)
Download PDF:
Previous Patent: TISSUE REPAIR BY MODULATION OF BETA-1 INTEGRIN BIOLOGICAL FUNCTION
Next Patent: MAST CELL-DERIVED RENIN
Next Patent: MAST CELL-DERIVED RENIN