Title:
THERAPEUTIC AGENT FOR OSTEOPOROSIS AND METHOD FOR SCREENING THERAPEUTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2014/104406
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a therapeutic or prophylactic agent for osteoporosis, said agent targeting a molecule causative of the onset of osteoporosis, and a method for screening the therapeutic or prophylactic agent.
Provided is a therapeutic agent for osteoporosis which comprises a compound, said compound targeting, as a target molecule, HIF1α, which has been identified as a molecule causative of osteoporosis, and being capable of inhibiting HIF1α. Also provided is a method for screening a compound which is usable as a therapeutic or prophylactic agent for osteoporosis with the use of the inhibition of HIF1α as an index.
Inventors:
MIYAMOTO TAKESHI (JP)
Application Number:
PCT/JP2013/085338
Publication Date:
July 03, 2014
Filing Date:
December 26, 2013
Export Citation:
Assignee:
UNIV KEIO (JP)
International Classes:
C12Q1/02; A61K31/565; A61K45/00; A61P19/10; G01N33/15; G01N33/50
Foreign References:
| KR20110081715A | 2011-07-14 |
Other References:
CICEK ET AL.: "2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo", CANCER RESEARCH, vol. 67, no. 21, 2007, pages 10106 - 10111
MARAN ET AL.: "2-methoxyestradiol inhibits differentiation and is cytotoxic to osteoclasts", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 99, no. 1, 2006, pages 425 - 434
STUBELIUS ET AL.: "Role of 2-methoxyestradiol as inhibitor of arthritis and osteoporosis in a model of postmenopausal rheumatoid arthritis", CLINICAL IMMUNOLOGY, vol. 140, no. 1, 2011, pages 37 - 46
MIYAUCHI ET AL.: "HIFla is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, no. 41, pages 16568 - 16573
LIU ET AL.: "The regulation of hypoxia inducible factor-la on osteoblast function in postmenopausal osteoporosis", CHINESE JOURNAL OF SURGERY, vol. 45, no. 18, 2007, pages 1274 - 1278
MARAN ET AL.: "2-methoxyestradiol inhibits differentiation and is cytotoxic to osteoclasts", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 99, no. 1, 2006, pages 425 - 434
STUBELIUS ET AL.: "Role of 2-methoxyestradiol as inhibitor of arthritis and osteoporosis in a model of postmenopausal rheumatoid arthritis", CLINICAL IMMUNOLOGY, vol. 140, no. 1, 2011, pages 37 - 46
MIYAUCHI ET AL.: "HIFla is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, no. 41, pages 16568 - 16573
LIU ET AL.: "The regulation of hypoxia inducible factor-la on osteoblast function in postmenopausal osteoporosis", CHINESE JOURNAL OF SURGERY, vol. 45, no. 18, 2007, pages 1274 - 1278
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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