THERAPEUTIC AGENT FOR PIGMENTED SKIN LESION

Title:

THERAPEUTIC AGENT FOR PIGMENTED SKIN LESION

Document Type and Number:

WIPO Patent Application WO/2008/020491

Kind Code:

A1

Abstract:

It is intended to provide a therapeutic agent effective in a pigmented skin lesion. The therapeutic agent for a pigmented skin lesion containing artocarpin as an active ingredient. Examples of the pigmented skin lesion includes not only a cafe-au-lait spot of Von Recklinghausen disease, a small Recklinghausen spot and neurofibroma, but also seborrheic keratosis and senile pigmented spot which are basically caused by hypermorphosis by the age-related change of epidermis but clinically considered as a pigmented lesion of skin, nevoid pigmentation disorders such as nevus spilus, melanocytic nevus, Ota's nevus, blue nevus and ectopic mongolian spot, postinflammatory pigmentation and the like.

Inventors:

NAKAYAMA JUICHIRO (JP)

Application Number:

PCT/JP2007/000816

Publication Date:

February 21, 2008

Filing Date:

July 31, 2007

Export Citation:

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Assignee:

KANSAI KOSO CO LTD (JP)
NAKAYAMA JUICHIRO (JP)

International Classes:

A61K31/353; A61K9/06; A61K9/08; A61K9/10; A61K9/70; A61P17/00; C07D311/30

Domestic Patent References:

WO2000045782A1	2000-08-10
WO2001028565A1	2001-04-26

Foreign References:

JP2002275030A	2002-09-25
JP2004196669A	2004-07-15

Other References:

ARUNG E.T. ET AL.: "Inibitory Effect of Isoprenoid-Substituted Flavonoids Isolated from Artocarpus heterophyllus on Melanin Biosynthesis", PLANTA MEDICA, vol. 72, no. 9, 2006, pages 847 - 850, XP002457791
SHIMIZU K. ET AL.: "Artocarpus Incisus Shinzai no UV-B Yudo Shikiso Chinchaku Yokusei Seibun", NIPPON NOGEI KAGAKU KAISHI 75, 2001, pages 143 + ABSTR. NO. 213A1, XP003019929

Attorney, Agent or Firm:

KATO, Hisashi (Asaco-Hakata Bldg.11-5, Hakataekihigashi 1-chome,Hakata-ku, Fukuoka-shi, Fukuoka 13, JP)

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