Title:
THERAPEUTIC AGENT FOR PROGRESSIVE DEMYELINATING IMMUNE DISEASE
Document Type and Number:
WIPO Patent Application WO/2016/114386
Kind Code:
A1
Abstract:
A therapeutic agent for progressive demyelinating immune disease containing, as an active ingredient thereof, a substance for suppressing or inhibiting signal transduction initiated by the PAR1 receptor.
Inventors:
YAMAMURA TAKASHI (JP)
OKI SHINJI (JP)
OKI SHINJI (JP)
Application Number:
PCT/JP2016/051124
Publication Date:
July 21, 2016
Filing Date:
January 15, 2016
Export Citation:
Assignee:
NAT CT NEUROLOGY & PSYCHIATRY (JP)
International Classes:
A61K45/00; A61K31/4035; A61K31/443; A61K31/454; A61K31/496; A61K31/5025; A61K31/5377; A61K31/7105; A61K38/00; A61K48/00; A61P25/00; A61P43/00
Domestic Patent References:
| WO2013113774A1 | 2013-08-08 | |||
| WO2002085850A1 | 2002-10-31 | |||
| WO2008128038A2 | 2008-10-23 | |||
| WO2015112547A1 | 2015-07-30 | |||
| WO2016002827A1 | 2016-01-07 |
Foreign References:
| JP2009542662A | 2009-12-03 | |||
| JP2010505836A | 2010-02-25 | |||
| JP2007523051A | 2007-08-16 | |||
| JP2008534604A | 2008-08-28 | |||
| JP2007084440A | 2007-04-05 |
Other References:
JIANG, W. ET AL.: "Unexpected role for granzyme K in CD 56bright NK cell -mediated immunoregulation of multiple sclerosis", THE JOURNAL OF IMMUNOLOGY, vol. 187, no. 2, 2011, pages 781 - 790
BURDA, J. E. ET AL.: "Critical role for PAR1 in Kallikrein 6-mediated oligodendrogliopathy", GLIA, vol. 61, no. 9, 2013, pages 1456 - 1470
RAMACHANDRAN, R. ET AL.: "Targeting proteinase- activated receptors: therapeutic potential and challenges", NATURE REVIEWS : DRUG DISCOVERY, vol. 11, no. 1, 2012, pages 69 - 86
NEUMANN, H. ET AL.: "Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases", TRENDS IN NEUROSCIENCES, vol. 25, no. 6, 2002, pages 313 - 319
RAVENEY, B. J. E. ET AL.: "Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation", NATURE COMMUNICATIONS, vol. 6, October 2015 (2015-10-01), pages 8437
BURDA, J. E. ET AL.: "Critical role for PAR1 in Kallikrein 6-mediated oligodendrogliopathy", GLIA, vol. 61, no. 9, 2013, pages 1456 - 1470
RAMACHANDRAN, R. ET AL.: "Targeting proteinase- activated receptors: therapeutic potential and challenges", NATURE REVIEWS : DRUG DISCOVERY, vol. 11, no. 1, 2012, pages 69 - 86
NEUMANN, H. ET AL.: "Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases", TRENDS IN NEUROSCIENCES, vol. 25, no. 6, 2002, pages 313 - 319
RAVENEY, B. J. E. ET AL.: "Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation", NATURE COMMUNICATIONS, vol. 6, October 2015 (2015-10-01), pages 8437
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Yoshiki Hasegawa (JP)
Yoshiki Hasegawa (JP)
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