Title:
THERAPEUTIC AGENT FOR PROMOTING RECOVERY OF ANIMAL UNDER MEDICAL TREATMENT
Document Type and Number:
WIPO Patent Application WO/2011/087102
Kind Code:
A1
Abstract:
Provided are a therapeutic agent, which is to be administered to an animal being in bad health and under a medical treatment to promote the recovery of physical conditions thereof, a therapeutic method and so on. The therapeutic agent for promoting recovery of physical conditions of an exhausted animal, which shows a decrease in activity (vitality) and is under a medical treatment, is characterized by containing, as the active ingredient, ghrelin, a derivative thereof or a pharmaceutically acceptable salt of the same, and enabling improvement in one or more evaluation items including activity (vitality), blood test data, biochemical test data, body temperature, anger/anxiety level and breathing rate.
Inventors:
MURAKAMI NOBORU (JP)
NAKAHARA KEIKO (JP)
KANGAWA KENJI (JP)
HAYASHI YUJIRO (JP)
NAKAHARA KEIKO (JP)
KANGAWA KENJI (JP)
HAYASHI YUJIRO (JP)
Application Number:
PCT/JP2011/050579
Publication Date:
July 21, 2011
Filing Date:
January 14, 2011
Export Citation:
Assignee:
UNIV MIYAZAKI (JP)
NAT CEREBRAL & CARDIOVASCULAR CT (JP)
DAIICHI SANKYO CO LTD (JP)
MURAKAMI NOBORU (JP)
NAKAHARA KEIKO (JP)
KANGAWA KENJI (JP)
HAYASHI YUJIRO (JP)
NAT CEREBRAL & CARDIOVASCULAR CT (JP)
DAIICHI SANKYO CO LTD (JP)
MURAKAMI NOBORU (JP)
NAKAHARA KEIKO (JP)
KANGAWA KENJI (JP)
HAYASHI YUJIRO (JP)
International Classes:
A61K38/22; A61P1/16; A61P3/00; A61P3/12; A61P7/00; A61P7/06; A61P11/00; A61P13/12; A61P25/00; A61P25/20; A61P25/22; A61P29/00; A61P37/02; A61P43/00
Domestic Patent References:
| WO2008136511A1 | 2008-11-13 | |||
| WO2004014412A1 | 2004-02-19 | |||
| WO2009119792A1 | 2009-10-01 | |||
| WO2002060472A1 | 2002-08-08 | |||
| WO2001007475A1 | 2001-02-01 |
Foreign References:
| JP2005507949A | 2005-03-24 | |||
| JP2007537276A | 2007-12-20 | |||
| JP2007523048A | 2007-08-16 | |||
| JP2008127377A | 2008-06-05 | |||
| JP2006241098A | 2006-09-14 | |||
| JP2005289863A | 2005-10-20 | |||
| JP2008237377A | 2008-10-09 | |||
| JP2009051847A | 2009-03-12 |
Other References:
N. NAGAYA ET AL.: "Effects of Ghrelin Administration on Left Ventricular Function, Exercise Capacity, and Muscle Wasting in Patients With Chronic Heart Failure", CIRCULATION, vol. 110, 2004, pages 3674 - 3679, XP002519085
N. NAGAYA ET AL.: "Treatment of Cachexia With Ghrelin in Patients With COPD", CHEST, vol. 128, 2005, pages 1187 - 1193, XP002519084
N. M. NEARY ET AL.: "Ghrelin Increases Energy Intake in Cancer Patients with Impaired Appetite: Acute, Randomized, Placebo-Controlled Trial", THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 89, 2004, pages 2832 - 2836, XP002379511
R. TAKEDA ET AL.: "Ghrelin Improves Renal Function in Mice with Ischemic Acute Renal Failure", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 17, 2006, pages 113 - 121, XP008066603
M. D. DEBOER ET AL.: "Ghrelin Treatment of Chronic Kidney Disease; Improvements in Lean Body Mass and Cytokine Profile", ENDOCRINOLOGY, vol. 149, 2008, pages 827 - 835, XP008155701
0. A. GARCIA ET AL.: "Administration of ghrelin to young uraemic rats increases food intake transiently, stimulates growth hormone secretion and does not improve longitudinal growth", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 22, 2007, pages 1309 - 1313, XP008155692
KAZUTOMO IMAHORI ET AL., SEIKAGAKU JITEN, 8 October 1998 (1998-10-08), KABUSHIKI KAISHA TOKYO, pages 1060, XP008155707
M. LUTTER ET AL.: "The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress", NATURE NEUROSCIENCE, vol. 11, no. 7, 2008, pages 752 - 753, XP008155709
See also references of EP 2524697A4
KOJ IMA ET AL., NATURE, vol. 402, 1999, pages 656 - 660
HOWARD ET AL., SCIENCE, vol. 273, 1996, pages 974 - 977
WREN ET AL., ENDOCRINOLOGY, vol. 141, 2000, pages 4325 - 4328
NAKAZATO ET AL., NATURE, vol. 409, 2001, pages 194 - 198
SHINTANI ET AL., DIABETES, vol. 50, 2001, pages 227 - 232
TSHOP ET AL., NATURE, vol. 407, 2000, pages 908 - 913
LELY ET AL., ENDOCR. REV., vol. 25, 2004, pages 656 - 660
KORBONITS ET AL., FRONT.NEUROENDOCRINOL., vol. 25, 2004, pages 27 - 68
KANGAWA ET AL., J. PHARMACOL. SCI., vol. 100, 2006, pages 398 - 410
D.M. BROOM, J. ANIMAL SCI., vol. 69, 1991, pages 4167 - 75
LON J RICH: "Interpretation of Biochemical Profiles", AAHA'S 45TH ANNUAL MEETING PROCEEDING'S, 1978
"Merck Manual of Medical Information", 2004
"The cat: diseases and clinical management", 1997, KATO G AND OSHIMA S. BUNEIDO PUBLISHING CO., LTD.
"Veterinary Internal Medicine (small animals", 2005, BUN-EIDO PUBLISHING CO., LTD., pages: 104
"Veterinary Internal Medicine", 2005, BUN-EIDO PUBLISHING CO., LTD., pages: 13
"Veterinary Internal Medicine Diagnostics", 1997, BUN-EIDO PUBLISHING CO., LTD.
"CKD Practice Guide", 2009
JENSEN M. ET AL., AM. J. PHYSIOL., vol. 268, pages E433 - E488
"Laboratory Test Guide 2003-2004", 2003, BUNKODO CO., LTD.
KOHASHI R: "All about tests for easy understanding of diseases and tests for diseases", 2003, SHUFUNOTOMO CO., LTD.
NISHIZAKI 0: "BOOKS of special course for nurses: Manual for reading test values", 2002, DIGIT BRAIN, INC.
ANDO Y: "Manual for understanding tests at hospital", 1999, SHOGAKKAN INC.
"Hematology in laboratory animals", 1981, SOFT SCIENCE INC.
J. MED. CHEM., vol. 43, 2000, pages 4370 - 4376
N. NAGAYA ET AL.: "Treatment of Cachexia With Ghrelin in Patients With COPD", CHEST, vol. 128, 2005, pages 1187 - 1193, XP002519084
N. M. NEARY ET AL.: "Ghrelin Increases Energy Intake in Cancer Patients with Impaired Appetite: Acute, Randomized, Placebo-Controlled Trial", THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, vol. 89, 2004, pages 2832 - 2836, XP002379511
R. TAKEDA ET AL.: "Ghrelin Improves Renal Function in Mice with Ischemic Acute Renal Failure", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 17, 2006, pages 113 - 121, XP008066603
M. D. DEBOER ET AL.: "Ghrelin Treatment of Chronic Kidney Disease; Improvements in Lean Body Mass and Cytokine Profile", ENDOCRINOLOGY, vol. 149, 2008, pages 827 - 835, XP008155701
0. A. GARCIA ET AL.: "Administration of ghrelin to young uraemic rats increases food intake transiently, stimulates growth hormone secretion and does not improve longitudinal growth", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 22, 2007, pages 1309 - 1313, XP008155692
KAZUTOMO IMAHORI ET AL., SEIKAGAKU JITEN, 8 October 1998 (1998-10-08), KABUSHIKI KAISHA TOKYO, pages 1060, XP008155707
M. LUTTER ET AL.: "The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress", NATURE NEUROSCIENCE, vol. 11, no. 7, 2008, pages 752 - 753, XP008155709
See also references of EP 2524697A4
KOJ IMA ET AL., NATURE, vol. 402, 1999, pages 656 - 660
HOWARD ET AL., SCIENCE, vol. 273, 1996, pages 974 - 977
WREN ET AL., ENDOCRINOLOGY, vol. 141, 2000, pages 4325 - 4328
NAKAZATO ET AL., NATURE, vol. 409, 2001, pages 194 - 198
SHINTANI ET AL., DIABETES, vol. 50, 2001, pages 227 - 232
TSHOP ET AL., NATURE, vol. 407, 2000, pages 908 - 913
LELY ET AL., ENDOCR. REV., vol. 25, 2004, pages 656 - 660
KORBONITS ET AL., FRONT.NEUROENDOCRINOL., vol. 25, 2004, pages 27 - 68
KANGAWA ET AL., J. PHARMACOL. SCI., vol. 100, 2006, pages 398 - 410
D.M. BROOM, J. ANIMAL SCI., vol. 69, 1991, pages 4167 - 75
LON J RICH: "Interpretation of Biochemical Profiles", AAHA'S 45TH ANNUAL MEETING PROCEEDING'S, 1978
"Merck Manual of Medical Information", 2004
"The cat: diseases and clinical management", 1997, KATO G AND OSHIMA S. BUNEIDO PUBLISHING CO., LTD.
"Veterinary Internal Medicine (small animals", 2005, BUN-EIDO PUBLISHING CO., LTD., pages: 104
"Veterinary Internal Medicine", 2005, BUN-EIDO PUBLISHING CO., LTD., pages: 13
"Veterinary Internal Medicine Diagnostics", 1997, BUN-EIDO PUBLISHING CO., LTD.
"CKD Practice Guide", 2009
JENSEN M. ET AL., AM. J. PHYSIOL., vol. 268, pages E433 - E488
"Laboratory Test Guide 2003-2004", 2003, BUNKODO CO., LTD.
KOHASHI R: "All about tests for easy understanding of diseases and tests for diseases", 2003, SHUFUNOTOMO CO., LTD.
NISHIZAKI 0: "BOOKS of special course for nurses: Manual for reading test values", 2002, DIGIT BRAIN, INC.
ANDO Y: "Manual for understanding tests at hospital", 1999, SHOGAKKAN INC.
"Hematology in laboratory animals", 1981, SOFT SCIENCE INC.
J. MED. CHEM., vol. 43, 2000, pages 4370 - 4376
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
Tatsu Iwatani (JP)
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Claims: