Title:
THERAPEUTIC AGENT FOR RENAL DISEASE AND RENAL FUNCTION-IMPROVING AGENT
Document Type and Number:
WIPO Patent Application WO/2024/043232
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel therapeutic agent for renal disease. The present invention is a therapeutic agent for renal disease containing a mesenchymal stem cell culture supernatant. The mesenchymal stem cell culture supernatant is preferably a culture supernatant obtained from the cultivation of mesenchymal stem cells derived from adipose tissue, umbilical tissue, or bone marrow tissue. In addition, the mesenchymal stem cell culture supernatant is preferably obtained from the cultivation of mesenchymal stem cells in a culture medium containing at least one substance selected from the group consisting of EGF, bFGF, albumin, transferrin, and insulin.
Inventors:
OTA SHIGEYUKI (JP)
KURATA HAYATO (JP)
KOIKE TETSUO (JP)
NOMI KIMIHITO (JP)
YAMADA KOTARO (JP)
KURATA HAYATO (JP)
KOIKE TETSUO (JP)
NOMI KIMIHITO (JP)
YAMADA KOTARO (JP)
Application Number:
PCT/JP2023/030142
Publication Date:
February 29, 2024
Filing Date:
August 22, 2023
Export Citation:
Assignee:
ROHTO PHARMA (JP)
International Classes:
A61K35/28; A61K35/35; A61K35/51; A61P13/12; C12N5/0775
Domestic Patent References:
| WO2021192670A1 | 2021-09-30 |
Foreign References:
| CN113274411A | 2021-08-20 |
Other References:
REN YIFEI, CHEN YING, ZHENG XIZI, WANG HUI, KANG XIN, TANG JIAWEI, QU LEI, SHAO XIAOYAN, WANG SUXIA, LI SHUANGLING, LIU GANG, YANG: "Human amniotic epithelial cells ameliorate kidney damage in ischemia-reperfusion mouse model of acute kidney injury", STEM CELL RESEARCH & THERAPY, BIOMED CENTRAL LTD, LONDON, UK, vol. 11, no. 1, 1 December 2020 (2020-12-01), London, UK , pages 410, XP093142696, ISSN: 1757-6512, DOI: 10.1186/s13287-020-01917-y
HUANG JIANNI, CAO HAO, CUI BINBIN, MA XIAOYAN, GAO LING, YU CHAO, SHEN FENGCHEN, YANG XINYU, LIU NA, QIU ANDONG, CAI GUANGYAN, ZHU: "Mesenchymal Stem Cells-Derived Exosomes Ameliorate Ischemia/Reperfusion Induced Acute Kidney Injury in a Porcine Model", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, FRONTIERS MEDIA, CH, vol. 10, 24 May 2022 (2022-05-24), CH , pages 899869, XP093142698, ISSN: 2296-634X, DOI: 10.3389/fcell.2022.899869
IWASAKI, KENGO; MORITA, IKUO: "Extracellular vesicle granules and diseases. Application of mesenchymal stem cell exosomes to disease treatment", SAISHIN IGAKU [=LATEST MEDICINE], SAISHIN IGAKU-SHA, OSAKA, JP, vol. 73, no. 9, 1 January 2018 (2018-01-01), JP , pages 1243 - 1253, XP009553228, ISSN: 0370-8241
ISHIKAWA TADAYASU: "Characteristic Analysis of Mesenchymal Stromal Cells Cultivated Using Serum-Free Medium R:STEM medium for MSC High Growth", PROGRAM OF THE 20TH CONGRESS OF THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE., 1 January 2021 (2021-01-01), pages 310, XP093142704, Retrieved from the Internet [retrieved on 20240319]
HUANG JIANNI, CAO HAO, CUI BINBIN, MA XIAOYAN, GAO LING, YU CHAO, SHEN FENGCHEN, YANG XINYU, LIU NA, QIU ANDONG, CAI GUANGYAN, ZHU: "Mesenchymal Stem Cells-Derived Exosomes Ameliorate Ischemia/Reperfusion Induced Acute Kidney Injury in a Porcine Model", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, FRONTIERS MEDIA, CH, vol. 10, 24 May 2022 (2022-05-24), CH , pages 899869, XP093142698, ISSN: 2296-634X, DOI: 10.3389/fcell.2022.899869
IWASAKI, KENGO; MORITA, IKUO: "Extracellular vesicle granules and diseases. Application of mesenchymal stem cell exosomes to disease treatment", SAISHIN IGAKU [=LATEST MEDICINE], SAISHIN IGAKU-SHA, OSAKA, JP, vol. 73, no. 9, 1 January 2018 (2018-01-01), JP , pages 1243 - 1253, XP009553228, ISSN: 0370-8241
ISHIKAWA TADAYASU: "Characteristic Analysis of Mesenchymal Stromal Cells Cultivated Using Serum-Free Medium R:STEM medium for MSC High Growth", PROGRAM OF THE 20TH CONGRESS OF THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE., 1 January 2021 (2021-01-01), pages 310, XP093142704, Retrieved from the Internet
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES (JP)
Download PDF:
Previous Patent: FLUX AND METHOD FOR PRODUCING ELECTRONIC COMPONENT
Next Patent: NOVEL COMBINATION OF STEVIOL GLYCOSIDES
Next Patent: NOVEL COMBINATION OF STEVIOL GLYCOSIDES