Title:
THERAPEUTIC AGENT FOR SARCOPENIA AND METABOLIC DISEASES
Document Type and Number:
WIPO Patent Application WO/2017/043630
Kind Code:
A1
Abstract:
The present invention provides a therapeutic agent for sarcopenia or metabolic diseases, which contains a mu-crystalline (CRYM)-inhibiting substance as an active ingredient. The inhibiting substance is selected from the group consisting of an antisense nucleic acid for CRYM, an RNAi-induced nucleic acid, a ribozyme or an expression vector therefore, an antagonist antibody, and a low-molecular-weight compound capable of inhibiting the activity of CRYM.
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Inventors:
ONO YUSUKE (JP)
Application Number:
PCT/JP2016/076627
Publication Date:
March 16, 2017
Filing Date:
September 09, 2016
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
International Classes:
A61K45/00; A61K31/7088; A61K31/7105; A61K31/713; A61K35/76; A61K35/761; A61K35/763; A61K39/395; A61K48/00; A61P3/00; A61P3/06; A61P3/08; A61P3/10; A61P21/00; A61P43/00; C12N15/09; C12N15/113
Domestic Patent References:
| WO2015064585A1 | 2015-05-07 |
Foreign References:
| US20090280517A1 | 2009-11-12 | |||
| JP2005137202A | 2005-06-02 |
Other References:
SATORU SUZUKI ET AL.: "Massho Tankakukyu ni Okeru CRYM Idenshi Hatsugen Teiryoho no Kakuritsu to Karei ni Okeru Totaisha tono Kankei", JAPANESE JOURNAL OF GERIATRICS, vol. 44, 2007, pages 118
YAMAUCHI, K. ET AL.: "Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein(xCTBP) with aldehyde dehydrogenase activity", EUR. J. BIOCHEM., vol. 269, no. 8, 2002, pages 2257 - 2264, XP055368393
SEKO, D. ET AL.: "p-Crystallin controls muscle function through thyroid hormone action", FASEB J., vol. 30, no. 5, May 2016 (2016-05-01), pages 1733 - 1740, XP055368394
SEKO, D. ET AL.: "The FSHD-related protein µ- crystallin controls metabolic and contractile properties in skeletal muscle", NEUROMUSCULAR DISORDERS, vol. 25, no. Suppl.2, October 2015 (2015-10-01), pages S215, XP055368395
YAMAUCHI, K. ET AL.: "Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein(xCTBP) with aldehyde dehydrogenase activity", EUR. J. BIOCHEM., vol. 269, no. 8, 2002, pages 2257 - 2264, XP055368393
SEKO, D. ET AL.: "p-Crystallin controls muscle function through thyroid hormone action", FASEB J., vol. 30, no. 5, May 2016 (2016-05-01), pages 1733 - 1740, XP055368394
SEKO, D. ET AL.: "The FSHD-related protein µ- crystallin controls metabolic and contractile properties in skeletal muscle", NEUROMUSCULAR DISORDERS, vol. 25, no. Suppl.2, October 2015 (2015-10-01), pages S215, XP055368395
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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