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Title:
THERAPEUTIC AGENT FOR SOLID CANCERS, WHICH CONTAINS AXL INHIBITOR AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2019/074116
Kind Code:
A1
Abstract:
The present invention addresses the problem of finding an effective method for treating solid cancers and providing a pharmaceutical product therefor. The present invention provides a therapeutic agent for solid cancers, which contains N-{5-[(6, 7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl}-2, 5- dioxo-1-phenyl-1, 2, 5, 6, 7, 8-hexahydro-3- quinolinecarboxamide, a pharmaceutically acceptable salt thereof, or a hydrate of the compound or the salt as an active ingredient, and which is characterized by being administered in combination with osimertinib or a pharmaceutically acceptable salt thereof. The combination of the present invention exerts a strong antitumor effect, and is therefore useful for treatment of solid cancers.

Inventors:
TAKAYAMA KOICHI (JP)
YAMADA TADAAKI (JP)
YASUHIRO TOMOKO (JP)
TANAKA KOHEI (JP)
Application Number:
PCT/JP2018/038202
Publication Date:
April 18, 2019
Filing Date:
October 12, 2018
Export Citation:
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Assignee:
ONO PHARMACEUTICAL CO (JP)
KYOTO PREFECTURAL PUBLIC UNIV CORP (JP)
International Classes:
A61K31/4709; A61K31/506; A61P35/00; A61P43/00; C07D401/14
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Other References:
JIMBO, T. ET AL.: "DS-12056, a novel, selective, small- molecule inhibitor of AXL, delays the onset of resistance and overcomes acquired resistance to EGFR-TKis in a human EGFR-mutant NSCLC (T790M-negative) xenograft model", ANNALS OF ONCOLOGY (ANN. ONCOL.), vol. 28, no. 5, September 2017 (2017-09-01), pages 132, XP009519900, ISSN: 1569-8041, Retrieved from the Internet DOI: 10.1093/annonc/mdx367
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See also references of EP 3695839A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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