Title:
THERAPEUTIC AGENT FOR SPINAL CORD INJURY
Document Type and Number:
WIPO Patent Application WO/2007/094166
Kind Code:
A1
Abstract:
A drug for recovery from a spinal cord injury, characterized by containing as an
active ingredient a compound represented by the following structural formula (1)
or a pharmaceutically acceptable salt thereof: Structural formula 1 (wherein R1
and R2 each independently is hydrogen, hydroxy, alkyl, or alkoxy;
and R3 is hydrogen, hydroxy, alkyl, alkoxy, or a sugar residue).
Inventors:
TOHDA CHIHIRO (JP)
NAKAYAMA NATSUKI (JP)
YAMADA MASASHI (JP)
SUZUKI HIROTO (JP)
NAKAYAMA NATSUKI (JP)
YAMADA MASASHI (JP)
SUZUKI HIROTO (JP)
Application Number:
PCT/JP2007/051458
Publication Date:
August 23, 2007
Filing Date:
January 30, 2007
Export Citation:
Assignee:
MEIJI DAIRIES CORP (JP)
TOHDA CHIHIRO (JP)
NAKAYAMA NATSUKI (JP)
YAMADA MASASHI (JP)
SUZUKI HIROTO (JP)
TOHDA CHIHIRO (JP)
NAKAYAMA NATSUKI (JP)
YAMADA MASASHI (JP)
SUZUKI HIROTO (JP)
International Classes:
A61K31/585; A23L1/30; A61K31/7048; A61P25/00; C07J17/00
Foreign References:
| JP2002255819A | 2002-09-11 | |||
| JP2004527472A | 2004-09-09 | |||
| JP2006176428A | 2006-07-06 |
Other References:
YE J.-H. ET AL.: "Treatment of the Chronically Injured Spinal Cord with Neurotrophic Factors Can Promote Axonal Regeneration from Supraspinal Neurons", EXPERIMENTAL NEUROLOGY, vol. 143, 1997, pages 70 - 81, XP003016639
BLESCH A. ET AL.: "Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair", BRAIN RESEARCH BULLETIN, vol. 57, no. 6, 2002, pages 833 - 838, XP003016640
JIAN A. ET AL.: "In situ gelling hydrogels for conformal repair of spinal cord defects, local delivery of BDNF after spinal cord injury", BIOMATERIALS, vol. 27, January 2006 (2006-01-01), pages 497 - 504, XP003016641
ZHAO J. ET AL.: "Withanolide Derivatives from the Roots of Withania somnifera and Their Neurite Outgrowth Activities", CHEM. PHARM. BULL., vol. 50, no. 6, 2002, pages 760 - 765, XP003016642
KUBOYAMA T.: "Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha", NEUROREPORT, vol. 13, no. 14, 2002, pages 1715 - 1720, XP003016643
TOHDA C. ET AL.: "Dendrite extension by methanol extract of Ashwaganda (roots of Withania somnifera) in SK-N-SH cells", NEUROREPORT, vol. 11, no. 9, 2000, pages 1981 - 1985, XP003016644
ATTA-UR-RAHMAN ET AL.: "TWO NEW WITHANOLIDES FROM WITHANIA SOMNIFERA", HETEROCYCLES, vol. 34, no. 4, 1992, pages 689 - 698, XP003016645
MATSUDA H. ET AL.: "Structures of Withanosides I, II, III, IV, V, VI, and VII, New Withanolide Glycosides, from the Roots of Indian Withania somnifera Dunal and Inhibitory Activity for Tchyphylaxis to Clonidine in Isolated Guinea-Pig Ileum", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9, 2001, pages 1499 - 1507, XP002991058
NAKAYAMA N. ET AL.: "Withanoside IV improves hindlimb function by facilitating axonal growth and increase in peripheral nervous system myelin level after spinal cord injury", NEUROSCIENCE, vol. 58, no. 2, June 2007 (2007-06-01), pages 176 - 182, XP022100926
NAKAYAMA N. ET AL.: "Withanoside IV no Keiko Toyo ni yoru Keitsui Sonsho Kaizen Sayo", NIPPON YAKUGAKUKAI NENKAI KOEN YOSHISHU, 126TH, DAI 126 NEN THE PHARMACEUTICAL SOCIETY OF JAPAN SENDAI 2006 YOKOSHU 3, 6 March 2006 (2006-03-06), pages 12 O3OUF]-029, XP003016646
BLESCH A. ET AL.: "Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair", BRAIN RESEARCH BULLETIN, vol. 57, no. 6, 2002, pages 833 - 838, XP003016640
JIAN A. ET AL.: "In situ gelling hydrogels for conformal repair of spinal cord defects, local delivery of BDNF after spinal cord injury", BIOMATERIALS, vol. 27, January 2006 (2006-01-01), pages 497 - 504, XP003016641
ZHAO J. ET AL.: "Withanolide Derivatives from the Roots of Withania somnifera and Their Neurite Outgrowth Activities", CHEM. PHARM. BULL., vol. 50, no. 6, 2002, pages 760 - 765, XP003016642
KUBOYAMA T.: "Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha", NEUROREPORT, vol. 13, no. 14, 2002, pages 1715 - 1720, XP003016643
TOHDA C. ET AL.: "Dendrite extension by methanol extract of Ashwaganda (roots of Withania somnifera) in SK-N-SH cells", NEUROREPORT, vol. 11, no. 9, 2000, pages 1981 - 1985, XP003016644
ATTA-UR-RAHMAN ET AL.: "TWO NEW WITHANOLIDES FROM WITHANIA SOMNIFERA", HETEROCYCLES, vol. 34, no. 4, 1992, pages 689 - 698, XP003016645
MATSUDA H. ET AL.: "Structures of Withanosides I, II, III, IV, V, VI, and VII, New Withanolide Glycosides, from the Roots of Indian Withania somnifera Dunal and Inhibitory Activity for Tchyphylaxis to Clonidine in Isolated Guinea-Pig Ileum", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9, 2001, pages 1499 - 1507, XP002991058
NAKAYAMA N. ET AL.: "Withanoside IV improves hindlimb function by facilitating axonal growth and increase in peripheral nervous system myelin level after spinal cord injury", NEUROSCIENCE, vol. 58, no. 2, June 2007 (2007-06-01), pages 176 - 182, XP022100926
NAKAYAMA N. ET AL.: "Withanoside IV no Keiko Toyo ni yoru Keitsui Sonsho Kaizen Sayo", NIPPON YAKUGAKUKAI NENKAI KOEN YOSHISHU, 126TH, DAI 126 NEN THE PHARMACEUTICAL SOCIETY OF JAPAN SENDAI 2006 YOKOSHU 3, 6 March 2006 (2006-03-06), pages 12 O3OUF]-029, XP003016646
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (1-1-1 Oroshi-machi, Tsuchiura-sh, Ibaraki 47, JP)
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