Title:
THERAPEUTIC AGENT AND TREATMENT METHOD FOR MULTIPLE SCLEROSIS THROUGH CONCOMITANT ADMINISTRATION OF HUMAN BONE MARROW-DERIVED MESENCHYMAL STEM CELL AND MINOCYCLINE
Document Type and Number:
WIPO Patent Application WO/2014/193060
Kind Code:
A1
Abstract:
The present invention relates to the concomitant administration of a human bone marrow-derived mesenchymal stem cell (hBM-MSC) and minocycline, and alleviates the clinical severity of multiple sclerosis compared to a conventional separate use of minocycline, and solves the problem of exhibiting anti-inflammatory and neuron protective effects and good resistance for long term use but having toxicity to CNS. The concomitant administration of hBM-MSC and minocycline exhibits a remarkable reduction in clinical score compared to the separate use thereof. Further, the concomitant administration of hBM-MSC and minocycline strengthens immunomodulatory effects, suppresses pro-inflammatory cytokines (IFN-γ, TNF-α) and conversely increases anti-inflammatory cytokines (IL-4, IL-10). In addition, the number of apoptotic cells is confirmed to be significantly reduced in TUNEL dyeing if hBM-MSC and minocycline are concomitantly administered compared to the separate use thereof. Therefore, the concomitant administration of hBM-MSC and minocycline can be used for treating multiple sclerosis.
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Inventors:
JEUN SIN-SOO (KR)
RYU CHUNG-HEON (KR)
RYU CHUNG-HEON (KR)
Application Number:
PCT/KR2013/011476
Publication Date:
December 04, 2014
Filing Date:
December 11, 2013
Export Citation:
Assignee:
CATHOLIC UNIV IND ACAD COOP (KR)
International Classes:
A61K35/28; A61K31/65; A61P25/00; A61P29/00
Foreign References:
| US20020022608A1 | 2002-02-21 | |||
| US20070238711A1 | 2007-10-11 | |||
| KR20100054759A | 2010-05-25 |
Other References:
LIANHUA BAI ET AL.: "Human bone marrow-derived mesenchymal stem cells induce Th2- polarized immune response and promote endogenous repair in animal models of multiple sclerosis", GLIA, vol. 57, 2009, pages 1192 - 1203
NAOKO NIIMI ET AL.: "Minocycline suppresses experimental autoimmune encephalomyelitis by increasing tissue inhibitors of metalloproteinases", NEUROPATHOLOGY, vol. 33, 14 April 2013 (2013-04-14), pages 612 - 620
NAOKO NIIMI ET AL.: "Minocycline suppresses experimental autoimmune encephalomyelitis by increasing tissue inhibitors of metalloproteinases", NEUROPATHOLOGY, vol. 33, 14 April 2013 (2013-04-14), pages 612 - 620
Attorney, Agent or Firm:
BAE, KIM & LEE IP GROUP (KR)
특허법인 태평양 (KR)
특허법인 태평양 (KR)
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