Title:
THERAPEUTIC COMPOSITION FOR BARRETT'S ESOPHAGUS
Document Type and Number:
WIPO Patent Application WO/2023/276866
Kind Code:
A1
Abstract:
The present invention pertains to a therapeutic composition for Barrett's esophagus and addresses the problem of providing a therapeutic composition for restoring Barrett's esophagus to normal esophagus and a method for treating Barrett's esophagus using the therapeutic composition. More specifically, the present invention pertains to a therapeutic composition for Barrett's esophagus, said composition containing an MEK inhibitor. Further, the present invention pertains to a composition for preventing esophageal adenocarcinoma, said composition containing an MEK inhibitor.
Inventors:
NOMURA SACHIYO (JP)
Application Number:
PCT/JP2022/025231
Publication Date:
January 05, 2023
Filing Date:
June 24, 2022
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A61K45/00; A61K31/18; A61K31/4184; A61K31/44; A61K31/4439; A61K31/4523; A61K31/506; A61K31/519; A61P1/04; A61P35/00; A61P43/00
Foreign References:
| JP2018528206A | 2018-09-27 |
Other References:
WANG LIN, LI XUEPING, ZHAO LAN, JIANG LONGYANG, SONG XINYUE, QI AOSHUANG, CHEN TING, JU MINGYI, HU BAOHUI, WEI MINJIE, HE MIAO, ZH: "Identification of DNA-Repair-Related Five-Gene Signature to Predict Prognosis in Patients with Esophageal Cancer", PATHOLOGY AND ONCOLOGY RESEARCH, vol. 27, 30 March 2021 (2021-03-30), XP093020374, DOI: 10.3389/pore.2021.596899
SI JIN, BEHAR JOSE, WANDS JACK, BEER DAVID G., LAMBETH DAVID, EUGENE CHIN Y., CAO WEIBIAO: "STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells", AMERICAN JOURNAL OF PHYSIOLOGY - GASTROINTESTINAL AND LIVER PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 294, no. 1, 1 January 2008 (2008-01-01), US , pages G174 - G183, XP093020376, ISSN: 0193-1857, DOI: 10.1152/ajpgi.00291.2007
YUKIYO NOMURA, TOMOHIKO YASUDA, TAKESHI TOYODA, EIJI UCHIDA, HIROSHI YOSHIDA, YASUYUKI SETO: "O36-5: Recovery of metaplastic mucosa in gastric mucosa of H. pylori-infected gerbils by the MEK inhibitor Selumetinib", GASTRONENTEROLOGICAL ENDOSCOPY, NIHON SHOKAKI NAISHIKYO GAKKAI, TOKYO, JP, vol. 61, no. Suppl. 1, 1 January 2019 (2019-01-01) - 2 June 2019 (2019-06-02), JP , pages 915, XP009542361, ISSN: 0387-1207, DOI: 10.11280/gee.61.855
YUKIYO NOMURA, FABIO TERABE, JO AIKO, SHINYA ODASHIMA, MITSUHIRO FUJISHIRO, YASUYUKI SETO: "Precancerous Conditions and Cancer High-risk Lesions in the Esophagus and the Stomach. 1 Esophagitis, Barrett's Epithelia and Adenocarinoma", RINSHO SHOKAKI NAIKA - CLINICAL GASTROENTEROLOGY, NIHON MEDIKARU SENTA,, JP, vol. 25, no. 3, 20 February 2010 (2010-02-20), JP , pages 273 - 278, XP009542349, ISSN: 0911-601X
SI JIN, BEHAR JOSE, WANDS JACK, BEER DAVID G., LAMBETH DAVID, EUGENE CHIN Y., CAO WEIBIAO: "STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells", AMERICAN JOURNAL OF PHYSIOLOGY - GASTROINTESTINAL AND LIVER PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, US, vol. 294, no. 1, 1 January 2008 (2008-01-01), US , pages G174 - G183, XP093020376, ISSN: 0193-1857, DOI: 10.1152/ajpgi.00291.2007
YUKIYO NOMURA, TOMOHIKO YASUDA, TAKESHI TOYODA, EIJI UCHIDA, HIROSHI YOSHIDA, YASUYUKI SETO: "O36-5: Recovery of metaplastic mucosa in gastric mucosa of H. pylori-infected gerbils by the MEK inhibitor Selumetinib", GASTRONENTEROLOGICAL ENDOSCOPY, NIHON SHOKAKI NAISHIKYO GAKKAI, TOKYO, JP, vol. 61, no. Suppl. 1, 1 January 2019 (2019-01-01) - 2 June 2019 (2019-06-02), JP , pages 915, XP009542361, ISSN: 0387-1207, DOI: 10.11280/gee.61.855
YUKIYO NOMURA, FABIO TERABE, JO AIKO, SHINYA ODASHIMA, MITSUHIRO FUJISHIRO, YASUYUKI SETO: "Precancerous Conditions and Cancer High-risk Lesions in the Esophagus and the Stomach. 1 Esophagitis, Barrett's Epithelia and Adenocarinoma", RINSHO SHOKAKI NAIKA - CLINICAL GASTROENTEROLOGY, NIHON MEDIKARU SENTA,, JP, vol. 25, no. 3, 20 February 2010 (2010-02-20), JP , pages 273 - 278, XP009542349, ISSN: 0911-601X
Attorney, Agent or Firm:
OKUHARA Koji (JP)
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