THERAPEUTIC COMPOSITIONS COMPRISING TRANSCRIPTION FACTORS AND METHODS OF MAKING AND USING THE SAME

Title:

THERAPEUTIC COMPOSITIONS COMPRISING TRANSCRIPTION FACTORS AND METHODS OF MAKING AND USING THE SAME

Document Type and Number:

WIPO Patent Application WO/2016/086227

Kind Code:

A3

Abstract:

The present invention relates to in vivo methods of delivering recombinant virions or viral vectors to a subject, including a human diagnosed with or suspected of having liver fibrosis. The disclosure also relates to methods in which recombinant virions, such as AAV virions, are introduced into the myofibroblasts of the liver and to deliver therapeutic nucleic acids, including those nucleic acids necessary to differentiate a myofibroblast into a hepatocyte, thereby not only improving liver function but also reducing collagen deposition and thus liver fibrosis.

Inventors:

WILLENBRING HOLGER (US)
DUMONT LAURE (US)
MALATO YANN (US)

Application Number:

PCT/US2015/062841

Publication Date:

August 18, 2016

Filing Date:

November 27, 2015

Export Citation:

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Assignee:

UNIV CALIFORNIA (US)

International Classes:

C12N15/86; C12N15/79; C12N15/864

Foreign References:

US20130251694A1	2013-09-26
US20130244331A1	2013-09-19
US20120093775A1	2012-04-19

Other References: