Title:
THERAPEUTIC AND DIAGNOSTIC METHODS FOR CANCER
Document Type and Number:
WIPO Patent Application WO/2016/196298
Kind Code:
A8
Abstract:
The present invention provides therapeutic and diagnostic methods and compositions for cancer, for example, bladder cancer. The invention provides methods of treating bladder cancer, methods of determining whether a patient suffering from bladder cancer is likely to respond to treatment comprising a PD-L1 axis binding antagonist, methods of predicting responsiveness of a patient suffering from bladder cancer to treatment comprising a PD-L1 axis binding antagonist, and methods of selecting a therapy for a patient suffering from bladder cancer, based on expression levels of a biomarker of the invention (e.g., PD-L1 expression levels in tumor-infiltrating immune cells in a tumor sample obtained from the patient) and/or based on the determination of a tumor sample subtype.
Inventors:
HEGDE PRITI (US)
KOWANETZ MARCIN (US)
FINE GREGG (US)
MARIATHASAN SANJEEV (US)
BOURGON RICHARD (US)
KOWANETZ MARCIN (US)
FINE GREGG (US)
MARIATHASAN SANJEEV (US)
BOURGON RICHARD (US)
Application Number:
PCT/US2016/034664
Publication Date:
June 08, 2017
Filing Date:
May 27, 2016
Export Citation:
Assignee:
GENENTECH INC (US)
HOFFMANN LA ROCHE (CH)
HOFFMANN LA ROCHE (CH)
International Classes:
C12Q1/68
Attorney, Agent or Firm:
ELBING, Karen L. (US)
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