THERAPEUTIC & DIAGNOSTICS COMPOSITIONS TARGETING TOLL-LIKE RECEPTORS AND METHODS THEREOF

Title:

THERAPEUTIC & DIAGNOSTICS COMPOSITIONS TARGETING TOLL-LIKE RECEPTORS AND METHODS THEREOF

Document Type and Number:

WIPO Patent Application WO/2018/165338

Kind Code:

A3

Abstract:

Therapeutic compositions and an associated method for improving a Toll-like receptor (TLR)-related condition, including determining a set of peptide sequences associated with a microorganism-related modulator of a TLR, determining a first set of binding parameters for the set of peptide sequences in relation to the TLR, selecting a target subset of peptide sequences from the set of peptide sequences based on the first set of binding parameters, reengineering the target subset of peptide sequences based on mutating amino acid residues of the target subset of peptide sequences, determining a second set of binding parameters for the reengineered target subset of peptide sequences in relation to the TLR, and identifying a first peptide for use in a therapeutic composition for improving the TLR-related condition, based on the second set of binding parameters for the reengineered target subset of peptide sequences.

Inventors:

APTE ZACHARY (US)
RICHMAN JESSICA (US)
ALMONACID DANIEL (US)
ALEGRIA MELISSA (US)
MARQUEZ VALERIA (US)
MORALES EDUARDO (US)
ORTIZ RODRIGO (US)
TORRES JANET (US)
CORRUBIAS PAULO (US)
GIMPEL JAVIER (US)
ARAYA INGRID (US)

Application Number:

PCT/US2018/021404

Publication Date:

October 11, 2018

Filing Date:

March 07, 2018

Export Citation:

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Assignee:

UBIOME INC (US)

International Classes:

C07K7/06; A61K38/08; C07K14/705

Domestic Patent References:

WO2016177797A1

2016-11-10

Foreign References:

US20090028889A1

2009-01-29

Attorney, Agent or Firm:

SCHOX, Jeffrey (US)

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