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Title:
THERAPEUTIC DRUG FOR DISEASES MAINLY INVOLVING TENOSYNOVIAL LESIONS
Document Type and Number:
WIPO Patent Application WO/2019/135363
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an effective therapeutic drug for various pathoses mainly involving tenosynovial lesions. Provided is a therapeutic drug comprising, as an active ingredient, tranilast or a pharmaceutically acceptable salt thereof.

Inventors:
HIRATA Hitoshi (1 Furo-cho, Chikusa-ku, Nagoya-sh, Aichi 01, 〒4648601, JP)
KAWAMOTO Hiroya (1 Furo-cho, Chikusa-ku, Nagoya-sh, Aichi 01, 〒4648601, JP)
IWATSUKI Katsuyuki (1 Furo-cho, Chikusa-ku, Nagoya-sh, Aichi 01, 〒4648601, JP)
Application Number:
JP2018/047135
Publication Date:
July 11, 2019
Filing Date:
December 21, 2018
Export Citation:
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Assignee:
NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY (1 Furo-cho, Chikusa-ku Nagoya-sh, Aichi 01, 〒4648601, JP)
International Classes:
A61K31/196; A61P21/00
Other References:
KATO, YOSHIYUKI ET AL.: "Tenosynovitis Diagnosed as Sarcoidosis of the Finger: A Case Report", THE JOURNAL OF THE CHUGOKU-SHIKOKU ORTHOPAEDIC ASSOCIATION, vol. 11, no. 1, 1999, pages 137 - 140, ISSN: 0915-2695
SHIOTA, N. ET AL.: "The anti-allergic compound tranilast attenuates inflammation and inhibits bone destruction in collagen-induced arthritis in mice", BRITISH JOURNAL OF PHARMACOLOGY, vol. 159, no. 3, February 2010 (2010-02-01), pages 626 - 635, XP055620299, ISSN: 0007-1188
KAIBARA, NOBUTAKA ET AL.: "A comparative review of tendinous synovitis and joint synovitis of rheumatoid arthritis", CONNECTIVE TISSUE, vol. 36, no. 2, 2004, pages 98, ISSN: 0916-572X
MIZUTANI, TAKAYA ET AL.: "Results of synovectomy for rheumatoid flexor tendon synovitis", THE JOURNAL OF JAPANESE ORTHOPAEDIC SURGICAL SOCIETY, vol. 75, no. 2, 2001, pages 314, ISSN: 0021-5325
XIA, C. ET AL.: "Effects of Antisense Transforming Growth Factor-beta1 Gene Transfer on the Biological Activities of Tendon Sheath Fibroblasts", ORTHOPEDICS, vol. 33, no. 8, August 2010 (2010-08-01), ISSN: 0147-7447, Retrieved from the Internet
WANG, S. ET AL.: "Gene expression of transforming growth factor beta-1 in tendon healing", JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH, vol. 12, no. 7, 2008, pages 1372 - 1375, ISSN: 1673-8225
YAMANAKA, Y. ET AL.: "Blocking fibrotic signaling in fibroblasts from patients with carpal tunnel syndrome", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 233, no. 3, 10 March 2018 (2018-03-10), pages 2067 - 2074, XP055620304, ISSN: 1097-4652
Attorney, Agent or Firm:
HAGINO Mikiharu (1-1 Technoplaza, Kakamigahara-shi Gifu, 09, 〒5090109, JP)
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