Title:
THERAPEUTIC DRUG OR PROPHYLACTIC DRUG FOR DIABETIC NEPHROPATHY
Document Type and Number:
WIPO Patent Application WO/2018/097294
Kind Code:
A1
Abstract:
The present invention pertains to a therapeutic drug or prophylactic drug for diabetic nephropathy, said drug comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient.
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Inventors:
SHIRAKURA TAKASHI (JP)
TSUJIMOTO SHUNSUKE (JP)
TSUBOSAKA YOSHIKI (JP)
TSUJIMOTO SHUNSUKE (JP)
TSUBOSAKA YOSHIKI (JP)
Application Number:
PCT/JP2017/042429
Publication Date:
May 31, 2018
Filing Date:
November 27, 2017
Export Citation:
Assignee:
TEIJIN PHARMA LTD (JP)
International Classes:
A61K31/427; A61P3/10; A61P13/12
Domestic Patent References:
| WO2014119681A1 | 2014-08-07 | |||
| WO2007043457A1 | 2007-04-19 | |||
| WO2016017826A1 | 2016-02-04 | |||
| WO2014140868A2 | 2014-09-18 | |||
| WO2012060308A1 | 2012-05-10 | |||
| WO2014119681A1 | 2014-08-07 |
Foreign References:
| JP2014510133A | 2014-04-24 | |||
| JP2016104774A | 2016-06-09 | |||
| CN103848796A | 2014-06-11 |
Other References:
KOSUGI, TOMOKI ET AL.: "Effect of lowering uric acid on renal disease in type 2 diabetic db/db mice", AM.J.PHYSIOL.RENAL PHYSIOL., vol. 297, no. 2, 20 May 2009 (2009-05-20), pages f481 - f488, XP055600858, ISSN: 1931-857x
LIU,P. ET AL.: "Allopurinol treatment improves renal functions in patients with type 2 diabetis and asymptomatic hyperuricemia: 3-year randomized parallel-controlled study", CLINICAL ENDOCRINOLOGY, vol. 83, no. 4, 29 December 2014 (2014-12-29), pages 475 - 482, XP009514406, ISSN: 0300-0664, DOI: 10.1111/cen.12673
KOMERS, R. ET AL.: "Effects of xanthine oxidase inhibition with febuxostat en the development of nephropathy in experimental type 2 diabetis", BRITISH JOURNAL OF PHARMACOLOGY, vol. 173, no. 17, 27 July 2016 (2016-07-27), pages 2573 - 2588, XP055600868
IRANIAN JOURNAL OF KIDNEY DISEASE, vol. 4, no. 2, 2010, pages 128 - 132
NEPHRON EXPERIMENTAL NEPHROLOGY, vol. 121, 2012, pages 109 - 121
AMERICAN JOURNAL OF NEPHROLOGY, vol. 40, 2014, pages 56 - 63
ARTHRITIS CARE & RESEARCH, vol. 64, no. 10, October 2012 (2012-10-01), pages 1431 - 1446
ANN RHEUM DIS, vol. 0, 2016, pages 1 - 14
AMERICAN JOURNAL OF PHYSIOLOGY RENAL PHYSIOLOGY, vol. 297, 2009, pages 481 - 488
NEPHRON EXPERIMENTAL PHYSIOLOGY, vol. 121, 2012, pages 109 - 121
See also references of EP 3545954A4
LIU,P. ET AL.: "Allopurinol treatment improves renal functions in patients with type 2 diabetis and asymptomatic hyperuricemia: 3-year randomized parallel-controlled study", CLINICAL ENDOCRINOLOGY, vol. 83, no. 4, 29 December 2014 (2014-12-29), pages 475 - 482, XP009514406, ISSN: 0300-0664, DOI: 10.1111/cen.12673
KOMERS, R. ET AL.: "Effects of xanthine oxidase inhibition with febuxostat en the development of nephropathy in experimental type 2 diabetis", BRITISH JOURNAL OF PHARMACOLOGY, vol. 173, no. 17, 27 July 2016 (2016-07-27), pages 2573 - 2588, XP055600868
IRANIAN JOURNAL OF KIDNEY DISEASE, vol. 4, no. 2, 2010, pages 128 - 132
NEPHRON EXPERIMENTAL NEPHROLOGY, vol. 121, 2012, pages 109 - 121
AMERICAN JOURNAL OF NEPHROLOGY, vol. 40, 2014, pages 56 - 63
ARTHRITIS CARE & RESEARCH, vol. 64, no. 10, October 2012 (2012-10-01), pages 1431 - 1446
ANN RHEUM DIS, vol. 0, 2016, pages 1 - 14
AMERICAN JOURNAL OF PHYSIOLOGY RENAL PHYSIOLOGY, vol. 297, 2009, pages 481 - 488
NEPHRON EXPERIMENTAL PHYSIOLOGY, vol. 121, 2012, pages 109 - 121
See also references of EP 3545954A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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