Title:
THERAPEUTIC EFFECTS OF GUANABENZ TREATMENT IN VANISHING WHITE MATTER
Document Type and Number:
WIPO Patent Application WO/2018/203751
Kind Code:
A8
Abstract:
The invention relates to Guanabenz or an analogue thereof for use in the treatment and to methods of treatment of a subject that has vanishing white matter (VWM), comprising administering the compound Guanabenz or an analogue thereof to the subject in need thereof. Also provided are methods with which the success of a medical intervention in a subject with VWM can be determined. Such methods comprise quantifying the translocation of Bergmann glia into the molecular layer in the cerebellum in a suitable sample of the sub ject. The sample is typically a post mortem sample.
Inventors:
VAN DER KNAAP MARGO SIENTJE (NL)
HEINE VIVI MAJELLA (NL)
ABBINK GERTRUDE ELISE MARIA (NL)
HEINE VIVI MAJELLA (NL)
ABBINK GERTRUDE ELISE MARIA (NL)
Application Number:
PCT/NL2018/050293
Publication Date:
November 21, 2019
Filing Date:
May 04, 2018
Export Citation:
Assignee:
STICHTING VUMC (NL)
International Classes:
A61K31/00; A61K31/4168; A61P25/28
Attorney, Agent or Firm:
WITMANS, H.A. (NL)
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