Title:
THERAPEUTIC HETEROCYCLIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2002055012
Kind Code:
A3
Abstract:
Provided herein is a compound having the formula (I) wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders. The compounds may also be useful in the treatment of gastrointestinal disorders, cardiovascular regulation, motor disorders, endocrine disorders, vasospasm and sexual dysfunction. The compounds are 5HT1B and 5HT1D antagonists.
Inventors:
CHAPDELAINE MARC (US)
DAVENPORT TIMOTHY (US)
HAEBERLEIN MARKUS (SE)
HORCHLER CAREY (US)
MCCAULEY JOHN (US)
PIERSON EDWARD (US)
SOHN DANIEL (SE)
DAVENPORT TIMOTHY (US)
HAEBERLEIN MARKUS (SE)
HORCHLER CAREY (US)
MCCAULEY JOHN (US)
PIERSON EDWARD (US)
SOHN DANIEL (SE)
Application Number:
PCT/SE2002/000068
Publication Date:
November 14, 2002
Filing Date:
January 15, 2002
Export Citation:
Assignee:
ASTRAZENECA AB (SE)
CHAPDELAINE MARC (US)
DAVENPORT TIMOTHY (US)
HAEBERLEIN MARKUS (SE)
HORCHLER CAREY (US)
MCCAULEY JOHN (US)
PIERSON EDWARD (US)
SOHN DANIEL (SE)
CHAPDELAINE MARC (US)
DAVENPORT TIMOTHY (US)
HAEBERLEIN MARKUS (SE)
HORCHLER CAREY (US)
MCCAULEY JOHN (US)
PIERSON EDWARD (US)
SOHN DANIEL (SE)
International Classes:
C07D215/48; A61K31/496; A61K31/5377; A61K31/541; A61K31/551; A61P5/00; A61P9/00; A61P15/00; A61P25/00; A61P25/02; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D215/50; C07D311/24; C07D311/58; C07D311/66; C07D401/04; C07D401/12; C07D405/06; C07D405/12; C07D405/14; C07D413/06; C07D413/12; C07D417/12; C07D521/00; (IPC1-7): C07D311/24; C07D311/74; C07D405/14; C07D417/14; C07D215/233; C07D215/48; C07D401/14; A61K31/5377; A61K31/497
Domestic Patent References:
| WO2000040554A1 | 2000-07-13 | |||
| WO1999005140A1 | 1999-02-04 |
Foreign References:
| US5605896A | 1997-02-25 | |||
| US5403842A | 1995-04-04 | |||
| US5965575A | 1999-10-12 | |||
| US5968954A | 1999-10-19 | |||
| US5914401A | 1999-06-22 | |||
| EP0104018A2 | 1984-03-28 | |||
| EP0017578A1 | 1980-10-15 | |||
| DE2331138A1 | 1974-01-10 |
Other References:
KERRIGAN FRANK ET AL.: "Synthesis of arylpiperazines via palladium-catalysed aromatic amination reactions of bromoarenes with N-tert-butoxycarbonylpiperazine", TETRAHEDRON LETTERS, vol. 39, 1998, pages 2219 - 2222, XP004110673
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