THERAPEUTIC MATERIAL FOR CEREBRAL INFARCTION, AND METHOD FOR REGENERATION OF BRAIN TISSUE

Title:

THERAPEUTIC MATERIAL FOR CEREBRAL INFARCTION, AND METHOD FOR REGENERATION OF BRAIN TISSUE

Document Type and Number:

WIPO Patent Application WO/2010/021412

Kind Code:

A1

Abstract:

Disclosed is a therapeutic material for cerebral infarction, which can recover a vascular disorder in an area affected by cerebral infarction to improve the brain function. The therapeutic material for cerebral infarction comprises a dental pulp stem cell comprising at least one member selected from a CD105-positive cell, an SP cell, a CD24-positive cell, a CD133-positive cell, a CD271-positive cell and a CD150-positive cell. The therapeutic material may additionally comprise a protein secreted from a dental pulp cell. A transplanted dental pulp stem cell cannot be differentiated directly into a neural progenitor cell or a neurocyte, but is involved indirectly in the promotion of differentiation to eliminate an area affected by cerebral infarction, thereby recovering the affected area into a normal area.

Inventors:

NAKASHIMA MISAKO (JP)
SUGIYAMA MASAHIKO (JP)

Application Number:

PCT/JP2009/065024

Publication Date:

February 25, 2010

Filing Date:

August 21, 2009

Export Citation:

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Assignee:

JAPAN HEALTH SCIENCE FOUND (JP)
NAKASHIMA MISAKO (JP)
SUGIYAMA MASAHIKO (JP)

International Classes:

A61L27/00; A61K35/32; A61K38/00; A61P9/00; A61P9/10; A61P25/00; A61P25/28; A61P43/00

Other References:

MASAHIKO SUGIYAMA ET AL.: "Shizui Yurai CD31-SP Saibo no Nokyoketsu Shikkan Chiryo ni Taisuru Yukosei no Kento", REGENERATIVE MEDICINE, NEN 2 GATSU, vol. 7, 2008, pages 255
MASAHIKO SUGIYAMA ET AL.: "Shizui CD31 Insei SP Saibo no Shizui Oyobi No Soshiki ni Okeru Shinkei'Kekkan Saisei ni Taisuru Koka no Kento", NIPPON SHIKA HOZON GAKKAI GAKUJUTSU TAIKAI PROGRAM OYOBI KOEN SHOROKUSHU, NEN 5 GATSU, vol. 128, 2008, pages 49