Title:
THERAPEUTIC OXIDATION CATALYSTS
Document Type and Number:
WIPO Patent Application WO2004047925
Kind Code:
A3
Abstract:
The present invention relates to the use of organotelenium and organotellerium GPx mimics for use as pro-oxidant catalysts and anti-oxidants.
Inventors:
JACOB CLAUS (GB)
GILES GREGORY (GB)
FRY FIONA (GB)
GILES GREGORY (GB)
FRY FIONA (GB)
Application Number:
PCT/GB2003/005095
Publication Date:
October 28, 2004
Filing Date:
November 24, 2003
Export Citation:
Assignee:
EXETER ANTIOXIDANT THERAPEUTIC (GB)
JACOB CLAUS (GB)
GILES GREGORY (GB)
FRY FIONA (GB)
JACOB CLAUS (GB)
GILES GREGORY (GB)
FRY FIONA (GB)
International Classes:
A61K31/095; A61P1/00; A61P9/00; A61P11/00; A61P19/00; A61P25/00; A61P25/28; A61P31/00; A61P35/00; C07C391/02; C07C395/00; (IPC1-7): A61P1/00; A61K31/095; A61P9/00; A61P11/00; A61P19/00; A61P25/00; A61P25/28; A61P31/00; A61P35/00
Domestic Patent References:
| WO1993016993A1 | 1993-09-02 |
Other References:
WILSON, S.R. ET AL.: "Development of Synthetic Compounds with Glutathione Peroxidase Activity", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 111, 1989, pages 5936 - 5939, XP002039295
GILES N M ET AL: "Redox catalysts as sensitisers towards oxidative stress", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 535, 9 January 2003 (2003-01-09), pages 179 - 182, XP002272681, ISSN: 0014-5793
BARBOSA, N. B. V. ET AL.: "Effect of Organic Forms of Selenium on gamma-Aminolevulinate Dehydratase from Liver, Kidney and Brain of Adult Rats", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 149, 9 January 1998 (1998-01-09), pages 243 - 253, XP002282834
GILES, G. I. ET AL.: "Electrochemistry of chalcogen compounds: prediction of antioxidant activity", CHEMICAL COMMUNICATIONS, vol. 23, 15 November 2001 (2001-11-15), pages 2490 - 2491, XP002282835
ENGMAN, L. ET AL.: "Diaryl Chalcogenides as Selective Inhibitors of Thioredoxin Reductase and Potential Antitumor Agents", ANTICANCER RESEARCH, vol. 17, 1997, pages 4599 - 4606, XP008030901
VASIL'EV, A. A. ET AL.: "Preparation of Unsymmetrical Diaryl Selenides via SNAr Reactions in eta 6-Cloroarene Transition Metal Complexes", ORGANOMETTALICS, vol. 18, no. 7, 1999, pages 1318 - 1325, XP002282836
SAKAKIBARA, M. ET AL.: "New Selenenylation Method. Synthesis of Selenonaphthoquinones and Selenoquinolinequinones Mediated by Phenyl Selenide Ion", JOURNAL OF CHEMICAL SOCIETY, 1991, pages 1231 - 1234, XP001189497
KEMMITT, T. ET AL.: "Synthesis and Multinuclear NMR Studies of [M{o- C6H4(TeMe)2}X2] (M = Pd, Pt; X = Cl, Br, I). The Presence of a Characteristic Ring Contribution to Te NMR Chemical Shifts", INORGANIC CHEMISTRY, vol. 29, 1990, pages 731 - 735, XP002282837
SINGH, A. K. ET AL.: "Ditelluroether ligand bis(4-methoxyphenyltelluro) methane- synthesis, reaction with iodine and its ruthenium(II) complexes", INORGANICA CHIMICA ACTA, vol. 304, 2000, pages 45 - 51, XP002282838
BACK, T. G. ET AL.: "Concise, Improved Procedure for the Synthesis of Brassinolide and Some Novel Side-Chain Analogues", JOURNAL OF ORGANIC CHEMISTRY, vol. 62, 1997, pages 1179 - 1182, XP002282839
KAUR, R. ET AL.: "Synthesis and Characterisation of Hybrid Bi- and Multidentate Tellurium LIgands Derived from N,N-Dimethylbenzylamine", ORGANOMETALLICS, vol. 14, 1995, pages 4755 - 4763, XP002282840
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285546, retrieved from STN Database accession no. 1994:483501
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285547, retrieved from STN Database accession no. 1999:583580
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285548, retrieved from STN Database accession no. 1972:128839
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285549, retrieved from STN Database accession no. 1987:18122
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285550, retrieved from STN Database accession no. 1983:215600
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285551, retrieved from STN Database accession no. 1995:994310
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285552, retrieved from STN Database accession no. 1996:241974
DATABASE CAOLD CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285553, retrieved from STN Database accession no. 90:137408
GILES N M ET AL: "Redox catalysts as sensitisers towards oxidative stress", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 535, 9 January 2003 (2003-01-09), pages 179 - 182, XP002272681, ISSN: 0014-5793
BARBOSA, N. B. V. ET AL.: "Effect of Organic Forms of Selenium on gamma-Aminolevulinate Dehydratase from Liver, Kidney and Brain of Adult Rats", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 149, 9 January 1998 (1998-01-09), pages 243 - 253, XP002282834
GILES, G. I. ET AL.: "Electrochemistry of chalcogen compounds: prediction of antioxidant activity", CHEMICAL COMMUNICATIONS, vol. 23, 15 November 2001 (2001-11-15), pages 2490 - 2491, XP002282835
ENGMAN, L. ET AL.: "Diaryl Chalcogenides as Selective Inhibitors of Thioredoxin Reductase and Potential Antitumor Agents", ANTICANCER RESEARCH, vol. 17, 1997, pages 4599 - 4606, XP008030901
VASIL'EV, A. A. ET AL.: "Preparation of Unsymmetrical Diaryl Selenides via SNAr Reactions in eta 6-Cloroarene Transition Metal Complexes", ORGANOMETTALICS, vol. 18, no. 7, 1999, pages 1318 - 1325, XP002282836
SAKAKIBARA, M. ET AL.: "New Selenenylation Method. Synthesis of Selenonaphthoquinones and Selenoquinolinequinones Mediated by Phenyl Selenide Ion", JOURNAL OF CHEMICAL SOCIETY, 1991, pages 1231 - 1234, XP001189497
KEMMITT, T. ET AL.: "Synthesis and Multinuclear NMR Studies of [M{o- C6H4(TeMe)2}X2] (M = Pd, Pt; X = Cl, Br, I). The Presence of a Characteristic Ring Contribution to Te NMR Chemical Shifts", INORGANIC CHEMISTRY, vol. 29, 1990, pages 731 - 735, XP002282837
SINGH, A. K. ET AL.: "Ditelluroether ligand bis(4-methoxyphenyltelluro) methane- synthesis, reaction with iodine and its ruthenium(II) complexes", INORGANICA CHIMICA ACTA, vol. 304, 2000, pages 45 - 51, XP002282838
BACK, T. G. ET AL.: "Concise, Improved Procedure for the Synthesis of Brassinolide and Some Novel Side-Chain Analogues", JOURNAL OF ORGANIC CHEMISTRY, vol. 62, 1997, pages 1179 - 1182, XP002282839
KAUR, R. ET AL.: "Synthesis and Characterisation of Hybrid Bi- and Multidentate Tellurium LIgands Derived from N,N-Dimethylbenzylamine", ORGANOMETALLICS, vol. 14, 1995, pages 4755 - 4763, XP002282840
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285546, retrieved from STN Database accession no. 1994:483501
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285547, retrieved from STN Database accession no. 1999:583580
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285548, retrieved from STN Database accession no. 1972:128839
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285549, retrieved from STN Database accession no. 1987:18122
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285550, retrieved from STN Database accession no. 1983:215600
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285551, retrieved from STN Database accession no. 1995:994310
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285552, retrieved from STN Database accession no. 1996:241974
DATABASE CAOLD CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285553, retrieved from STN Database accession no. 90:137408
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