Title:
THERAPEUTIC AND/OR PREVENTIVE AGENT COMPRISING 1-INDANSULFAMIDE DERIVATIVE FOR PAIN
Document Type and Number:
WIPO Patent Application WO/2015/093515
Kind Code:
A1
Abstract:
A medicine comprising a 1-indansulfamide compound such as N-[(1s)-2,2,5,7-tetrafluoro-2,3-dihydro-1H-indene-1-yl]sulfamide, or N-[(1s)-2,2-difluoro-7-methyl-2,3-dihydro-1H-indene-1-yl]sulfamide, or a pharmaceutically acceptable salt thereof has an analgesic effect in the mouse hot-plate test and rat constriction nerve injury model and thus holds promise as a therapeutic agent for acute pain and chronic pain.
Inventors:
HIGASHIYAMA HIROYUKI (JP)
KAZUTA YUJI (JP)
HASHIMOTO KEISUKE (JP)
KAZUTA YUJI (JP)
HASHIMOTO KEISUKE (JP)
Application Number:
PCT/JP2014/083374
Publication Date:
June 25, 2015
Filing Date:
December 17, 2014
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
International Classes:
A61K31/18; A61P25/04
Domestic Patent References:
| WO2013191144A1 | 2013-12-27 | |||
| WO2010115952A1 | 2010-10-14 | |||
| WO2012038081A1 | 2012-03-29 | |||
| WO2007095615A2 | 2007-08-23 | |||
| WO2007075752A1 | 2007-07-05 | |||
| WO2008083248A2 | 2008-07-10 |
Foreign References:
| US20080096903A1 | 2008-04-24 |
Other References:
"Pain Definitions", PAIN, vol. 6, no. 3, 1979, pages 247 - 248
"Japanese translation of Neuropathic Pain - A report of Tenninology Committee, the Japan Society of Pain Clinicians", JOURNAL OF JAPAN SOCIETY OF PAIN CLINICIANS, vol. 16, no. 4, 2009, pages 509 - 514
TREEDE, RD.; JENSEN,T.S.; CAMPBELL), J.N. ET AL.: "Neuropathic pain: Redefinition and a grading system for clinical and research purposes", NEUROLOGY, vol. 70, 2008, pages 1630 - 1635
PHILLIP, DM.: "JCAHO: Pain management standards are unveiled", JAMA, vol. 284, no. 4, 2000, pages 428 - 429
WU, C.L; RAJA, S.N.: "Treatment of acute postoperative pain", LANCET, vol. 377, no. 9784, 2011, pages 2215 - 2225
BREIVIK. H.; COLLETT, B.; VENTAFRIDDA, V; COHEN, R; GALLACHER, D.: "Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment", EUROPEANJOUMAL OF PAIN, vol. 10, no. 4, 2006, pages 287 - 333, XP005347256, DOI: doi:10.1016/j.ejpain.2005.06.009
DUBUISSON, D.; STEPHEN, G: "The formalin test A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats", PAIN, vol. 4, no. 2, 1977, pages 161 - 174
WANG, L.X.; WANG, Z.: "Animal and cellular models of chronic pain", ADVANCED DRUG DELIVERY REVIEWS, vol. 55, no. 8, 2003, pages 949 - 965
ORGANIC LETTERS, vol. 3, 2001, pages 2241
MALMBERG, A.; YAKSB, T., PAIN, vol. 60, 1995, pages 83 - 90
BENNETT, G J.; XIE, Y K., PAIN, vol. 33, 1988, pages 87 - 107
CHAPLAN ET AL., J NEUROSCIENCE METHODS, vol. 53, no. 1, 1994, pages 55 - 63
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, vol. 20, 1980, pages 441 - 462
DUBUISSON; DENNIS, PAIN, vol. 4, 1977, pages 161 - 174
See also references of EP 3085369A4
"Japanese translation of Neuropathic Pain - A report of Tenninology Committee, the Japan Society of Pain Clinicians", JOURNAL OF JAPAN SOCIETY OF PAIN CLINICIANS, vol. 16, no. 4, 2009, pages 509 - 514
TREEDE, RD.; JENSEN,T.S.; CAMPBELL), J.N. ET AL.: "Neuropathic pain: Redefinition and a grading system for clinical and research purposes", NEUROLOGY, vol. 70, 2008, pages 1630 - 1635
PHILLIP, DM.: "JCAHO: Pain management standards are unveiled", JAMA, vol. 284, no. 4, 2000, pages 428 - 429
WU, C.L; RAJA, S.N.: "Treatment of acute postoperative pain", LANCET, vol. 377, no. 9784, 2011, pages 2215 - 2225
BREIVIK. H.; COLLETT, B.; VENTAFRIDDA, V; COHEN, R; GALLACHER, D.: "Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment", EUROPEANJOUMAL OF PAIN, vol. 10, no. 4, 2006, pages 287 - 333, XP005347256, DOI: doi:10.1016/j.ejpain.2005.06.009
DUBUISSON, D.; STEPHEN, G: "The formalin test A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats", PAIN, vol. 4, no. 2, 1977, pages 161 - 174
WANG, L.X.; WANG, Z.: "Animal and cellular models of chronic pain", ADVANCED DRUG DELIVERY REVIEWS, vol. 55, no. 8, 2003, pages 949 - 965
ORGANIC LETTERS, vol. 3, 2001, pages 2241
MALMBERG, A.; YAKSB, T., PAIN, vol. 60, 1995, pages 83 - 90
BENNETT, G J.; XIE, Y K., PAIN, vol. 33, 1988, pages 87 - 107
CHAPLAN ET AL., J NEUROSCIENCE METHODS, vol. 53, no. 1, 1994, pages 55 - 63
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, vol. 20, 1980, pages 441 - 462
DUBUISSON; DENNIS, PAIN, vol. 4, 1977, pages 161 - 174
See also references of EP 3085369A4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Yoshiki Hasegawa (JP)
Yoshiki Hasegawa (JP)
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