Title:
THERAPEUTIC AND/OR PREVENTIVE AGENT FOR CORONAVIRUS DISEASE 2019 (COVID-19)
Document Type and Number:
WIPO Patent Application WO/2021/215517
Kind Code:
A1
Abstract:
The present invention provides: a therapeutic and/or preventive agent for coronavirus disease 2019 (COVID-19) that contains 5-aminolevulinic acid (ALA), a derivative thereof or a salt of the same; and a method for treating and/or preventing COVID-19 by using the therapeutic and/or preventive agent.
Inventors:
KITA KIYOSHI (JP)
MORITA KOUICHI (JP)
YASUDA JIRO (JP)
SAKURAI YASUTERU (JP)
KAWATA SATOFUMI (JP)
TANAKA TOHRU (JP)
TOMIOKA MOTOYASU (JP)
FUJINE KIYOTAKA (JP)
MORITA KOUICHI (JP)
YASUDA JIRO (JP)
SAKURAI YASUTERU (JP)
KAWATA SATOFUMI (JP)
TANAKA TOHRU (JP)
TOMIOKA MOTOYASU (JP)
FUJINE KIYOTAKA (JP)
Application Number:
PCT/JP2021/016372
Publication Date:
October 28, 2021
Filing Date:
April 22, 2021
Export Citation:
Assignee:
NEOPHARMA JAPAN CO LTD (JP)
UNIV NAGASAKI (JP)
UNIV NAGASAKI (JP)
International Classes:
A61K31/197; A61K31/295; A61K31/4985; A61K33/06; A61K33/24; A61K33/26; A61K33/30; A61K45/00; A61P31/14; A61P43/00
Domestic Patent References:
WO2014013664A1 | 2014-01-23 | |||
WO2020218577A1 | 2020-10-29 | |||
WO2014202383A1 | 2014-12-24 | |||
WO2004069233A1 | 2004-08-19 | |||
WO2004069243A1 | 2004-08-19 | |||
WO2006106778A1 | 2006-10-12 | |||
WO2009072267A1 | 2009-06-11 |
Foreign References:
JP2000510123A | 2000-08-08 |
Other References:
WU, FAN ET AL.: "A new coronavirus associated with human respiratory disease", CHINA, NATURE, vol. 579, 3 February 2020 (2020-02-03), pages 265 - 269, XP037525882, DOI: 10.1038/s41586-020-2008-3
YANG, XUE ET AL.: "Aminolevulinic Acid-Based Tumor Detection and Therapy: Molecular Mechanisms and Strategies for Enhancement", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 16, 2015, pages 25865 - 25880, XP055759593, DOI: 10.3390/ijms161025865
JIMMY SUSANTO, YU-HSING LIN, YUN-NAN CHEN, CHIA-RUI SHEN, YU-TING YAN, SHENG-TA TSAI, CHUNG-HSUAN CHEN, CHIA-NING SHEN: "Porphyrin Homeostasis Maintained by ABCG2 Regulates Self-Renewal of Embryonic Stem Cells", PLOS ONE, vol. 3, no. 12, pages e4023, XP055320025, DOI: 10.1371/journal.pone.0004023
ITO, HIDENORI ET AL.: "Oral administration of 5-aminolevulinic acid induces heme oxygenase-1 expression in peripheral blood mononuclear cells of healthy human subjects in combination with ferrous iron", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 833, 2018, pages 25 - 33, XP055759241, DOI: 10.1016/j.ejphar.2018.05.009
ZHAO, MINGYI ET AL.: "5 -Aminolevulinic acid combined with sodium ferrous citrate ameliorates H202-induced cardiomyocyte hypertrophy via activation of the MAPK/Nrf2/HO-1 pathwa y", AM J PHYSIOL CELL PHYSIOL, vol. 308, 2015, pages C665 - C672, XP055759245, DOI: 10.1152/ajpcell.00369.2014
SAKURAI YASUTERU, NGWE TUN MYA MYAT, KUROSAKI YOHEI, SAKURA TAKAYA, INAOKA DANIEL KEN, FUJINE KIYOTAKA, KITA KIYOSHI, MORITA KOUIC: "5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 545, 1 March 2021 (2021-03-01), Amsterdam NL , pages 203 - 207, XP055867915, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2021.01.091
TAKANO TOMOMI, SATOH KUMI, DOKI TOMOYOSHI: "Possible Antiviral Activity of 5-Aminolevulinic Acid in Feline Infectious Peritonitis Virus (Feline Coronavirus) Infection", FRONTIERS IN VETERINARY SCIENCE, vol. 8, XP055867919, DOI: 10.3389/fvets.2021.647189
GU CHENJIAN, WU YANG, GUO HUIMIN, ZHU YUANFEI, XU WEI, WANG YUYAN, ZHOU YU, SUN ZHIPING, CAI XIA, LI YUTANG, LIU JING, HUANG ZHONG: "Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2", SCIENCE BULLETIN, ZHONGGUO KEXUE ZAZHISHE, CN, vol. 66, no. 9, 1 May 2021 (2021-05-01), CN , pages 925 - 936, XP055867921, ISSN: 2095-9273, DOI: 10.1016/j.scib.2020.12.005
ROSSI, MAXIME ET AL.: "Heme oxygenase-1 (HO-1) cytoprotective pathway: A potential treatment strategy against coronavirus disease 2019 (COVID-19)- induced cytokine storm syndrome", MEDICAL HYPOTHESES, vol. 144, no. 110242, 3 September 2020 (2020-09-03), pages 1 - 4, XP086361066, DOI: 10.1016/j.mehy.2020.110242
SINGH, DEVENDRA ET AL.: "Heme oxygenase-1 modulation: A potential therapeutic target for COVID-19 and associated complications", FREE RADICAL BIOLOGY AND MEDICINE, vol. 161, 19 October 2020 (2020-10-19), pages 263 - 271, XP086389131, DOI: 10.1016/j.freeradbiomed.2020.10.016
ANONYMOUS: "History of Changes for Study: NCT04542850", CLINICALTRIALS.GOV ARCHIVE, 6 September 2020 (2020-09-06), XP055867952, Retrieved from the Internet [retrieved on 20211201]
CELL RESEARCH, vol. 30, 2020, pages 269 - 271
SCIENTIFIC REPORTS, vol. 9, no. 8666, 2019
REVIEW IN MEDICAL VIROLOGY, 16 March 2021 (2021-03-16)
THE MINISTRY OF HEALTH, LABOUR AND WELFARE, RESPONSE TO CORONAVIRUS DISEASE 2019 (VARIANTS, 20 April 2021 (2021-04-20), Retrieved from the Internet
PHOTOCHEM PHOTOBIOL, vol. 86, no. 2, 2010, pages 471 - 475
CANCER RES, vol. 71, no. 18, 2011, pages 6040 - 6050
INT J BIOCHEM MOL BIOL, vol. 3, no. 1, 2012, pages 1 - 27
CHIN J CANCER, vol. 31, no. 2, 2012, pages 75 - 99
MOL. CANCER THER., vol. 1, 2002, pages 417 - 425
MOL. CANCER THER., vol. 2, 2003, pages 105 - 112
INT. J. CANCER, vol. 108, 2004, pages 146 - 151
BIOCHEM. BIOPHYS. REP., vol. 11, 2017, pages 105 - 111
See also references of EP 4140479A1
YANG, XUE ET AL.: "Aminolevulinic Acid-Based Tumor Detection and Therapy: Molecular Mechanisms and Strategies for Enhancement", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 16, 2015, pages 25865 - 25880, XP055759593, DOI: 10.3390/ijms161025865
JIMMY SUSANTO, YU-HSING LIN, YUN-NAN CHEN, CHIA-RUI SHEN, YU-TING YAN, SHENG-TA TSAI, CHUNG-HSUAN CHEN, CHIA-NING SHEN: "Porphyrin Homeostasis Maintained by ABCG2 Regulates Self-Renewal of Embryonic Stem Cells", PLOS ONE, vol. 3, no. 12, pages e4023, XP055320025, DOI: 10.1371/journal.pone.0004023
ITO, HIDENORI ET AL.: "Oral administration of 5-aminolevulinic acid induces heme oxygenase-1 expression in peripheral blood mononuclear cells of healthy human subjects in combination with ferrous iron", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 833, 2018, pages 25 - 33, XP055759241, DOI: 10.1016/j.ejphar.2018.05.009
ZHAO, MINGYI ET AL.: "5 -Aminolevulinic acid combined with sodium ferrous citrate ameliorates H202-induced cardiomyocyte hypertrophy via activation of the MAPK/Nrf2/HO-1 pathwa y", AM J PHYSIOL CELL PHYSIOL, vol. 308, 2015, pages C665 - C672, XP055759245, DOI: 10.1152/ajpcell.00369.2014
SAKURAI YASUTERU, NGWE TUN MYA MYAT, KUROSAKI YOHEI, SAKURA TAKAYA, INAOKA DANIEL KEN, FUJINE KIYOTAKA, KITA KIYOSHI, MORITA KOUIC: "5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 545, 1 March 2021 (2021-03-01), Amsterdam NL , pages 203 - 207, XP055867915, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2021.01.091
TAKANO TOMOMI, SATOH KUMI, DOKI TOMOYOSHI: "Possible Antiviral Activity of 5-Aminolevulinic Acid in Feline Infectious Peritonitis Virus (Feline Coronavirus) Infection", FRONTIERS IN VETERINARY SCIENCE, vol. 8, XP055867919, DOI: 10.3389/fvets.2021.647189
GU CHENJIAN, WU YANG, GUO HUIMIN, ZHU YUANFEI, XU WEI, WANG YUYAN, ZHOU YU, SUN ZHIPING, CAI XIA, LI YUTANG, LIU JING, HUANG ZHONG: "Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2", SCIENCE BULLETIN, ZHONGGUO KEXUE ZAZHISHE, CN, vol. 66, no. 9, 1 May 2021 (2021-05-01), CN , pages 925 - 936, XP055867921, ISSN: 2095-9273, DOI: 10.1016/j.scib.2020.12.005
ROSSI, MAXIME ET AL.: "Heme oxygenase-1 (HO-1) cytoprotective pathway: A potential treatment strategy against coronavirus disease 2019 (COVID-19)- induced cytokine storm syndrome", MEDICAL HYPOTHESES, vol. 144, no. 110242, 3 September 2020 (2020-09-03), pages 1 - 4, XP086361066, DOI: 10.1016/j.mehy.2020.110242
SINGH, DEVENDRA ET AL.: "Heme oxygenase-1 modulation: A potential therapeutic target for COVID-19 and associated complications", FREE RADICAL BIOLOGY AND MEDICINE, vol. 161, 19 October 2020 (2020-10-19), pages 263 - 271, XP086389131, DOI: 10.1016/j.freeradbiomed.2020.10.016
ANONYMOUS: "History of Changes for Study: NCT04542850", CLINICALTRIALS.GOV ARCHIVE, 6 September 2020 (2020-09-06), XP055867952, Retrieved from the Internet
CELL RESEARCH, vol. 30, 2020, pages 269 - 271
SCIENTIFIC REPORTS, vol. 9, no. 8666, 2019
REVIEW IN MEDICAL VIROLOGY, 16 March 2021 (2021-03-16)
THE MINISTRY OF HEALTH, LABOUR AND WELFARE, RESPONSE TO CORONAVIRUS DISEASE 2019 (VARIANTS, 20 April 2021 (2021-04-20), Retrieved from the Internet
PHOTOCHEM PHOTOBIOL, vol. 86, no. 2, 2010, pages 471 - 475
CANCER RES, vol. 71, no. 18, 2011, pages 6040 - 6050
INT J BIOCHEM MOL BIOL, vol. 3, no. 1, 2012, pages 1 - 27
CHIN J CANCER, vol. 31, no. 2, 2012, pages 75 - 99
MOL. CANCER THER., vol. 1, 2002, pages 417 - 425
MOL. CANCER THER., vol. 2, 2003, pages 105 - 112
INT. J. CANCER, vol. 108, 2004, pages 146 - 151
BIOCHEM. BIOPHYS. REP., vol. 11, 2017, pages 105 - 111
See also references of EP 4140479A1
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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