Title:
THERAPEUTIC OR PROPHYLACTIC AGENT FOR CACHEXIA ACCOMPANIED BY GHRELIN RESISTANCE
Document Type and Number:
WIPO Patent Application WO/2022/225045
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a therapeutic or prophylactic agent for cachexia accompanied by ghrelin resistance. The present invention provides a therapeutic or prophylactic agent for cachexia accompanied by ghrelin resistance, the agent containing, as an active ingredient, an opioid κ receptor agonist compound represented by the compound.
Inventors:
UCHIDA MASASHI (JP)
OMORI YU (JP)
OMORI YU (JP)
Application Number:
PCT/JP2022/018548
Publication Date:
October 27, 2022
Filing Date:
April 22, 2022
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
International Classes:
A61K45/00; A61K31/485; A61K38/07; A61P7/00; A61P35/00; A61P39/06; A61P43/00
Domestic Patent References:
| WO2012105475A1 | 2012-08-09 | |||
| WO2021079978A1 | 2021-04-29 | |||
| WO2005097261A1 | 2005-10-20 | |||
| WO1993015081A1 | 1993-08-05 | |||
| WO2012105475A1 | 2012-08-09 | |||
| WO2008057608A2 | 2008-05-15 |
Foreign References:
| JP2018062488A | 2018-04-19 | |||
| JP2010509343A | 2010-03-25 | |||
| JP2021073026A | 2021-05-13 |
Other References:
STEELE, T.D. ; BRYANT, H.U. ; MALVEN, P.V. ; YIM, G.K.W.: "Nocturnal depletion of hypothalamic dynorphin in anorexic walker-256 tumor-bearing rats", PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR., ELSEVIER., US, vol. 29, no. 3, 1 March 1988 (1988-03-01), US , pages 541 - 545, XP023777116, ISSN: 0091-3057, DOI: 10.1016/0091-3057(88)90017-2
TERAWAKI KIYOSHI, KASHIWASE YOHEI, SAWADA YUMI, HASHIMOTO HIROFUMI, YOSHIMURA MITSUHIRO, OHBUCHI KATSUYA, SUDO YUKA, SUZUKI MASAMI: "Development of ghrelin resistance in a cancer cachexia rat model using human gastric cancer-derived 85As2 cells and the palliative effects of the Kampo medicine rikkunshito on the model", PLOS ONE, vol. 12, no. 3, 1 March 2017 (2017-03-01), pages e0173113, XP055978858, DOI: 10.1371/journal.pone.0173113
KERN ET AL., JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, vol. 12, 1988, pages 286 - 298
KOJIMAKANGAWA, PHYSIOLOGICAL REVIEWS, vol. 85, 2005, pages 495 - 522
NAKAZATO ET AL., NATURE, vol. 409, 2001, pages 194 - 198
SHIMIZU ET AL., CLIN. CANCER RES., vol. 9, 2003, pages 774 - 778
NELSON ET AL., JOURNAL OF CLINICAL ONCOLOGY, vol. 12, 1994, pages 213 - 225
TERAWAKI ET AL., PLOS ONE, vol. 12, 2017, pages e0173113
ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING, vol. 6, 2019, pages 227 - 233
SUPPORT CARE CANCER, vol. 21, 2013, pages 2409 - 2415
JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE, vol. 5, 2014, pages 329 - 337
TERAWAKI KIYOSHI, KASHIWASE YOHEI, SAWADA YUMI, HASHIMOTO HIROFUMI, YOSHIMURA MITSUHIRO, OHBUCHI KATSUYA, SUDO YUKA, SUZUKI MASAMI: "Development of ghrelin resistance in a cancer cachexia rat model using human gastric cancer-derived 85As2 cells and the palliative effects of the Kampo medicine rikkunshito on the model", PLOS ONE, vol. 12, no. 3, 1 March 2017 (2017-03-01), pages e0173113, XP055978858, DOI: 10.1371/journal.pone.0173113
KERN ET AL., JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, vol. 12, 1988, pages 286 - 298
KOJIMAKANGAWA, PHYSIOLOGICAL REVIEWS, vol. 85, 2005, pages 495 - 522
NAKAZATO ET AL., NATURE, vol. 409, 2001, pages 194 - 198
SHIMIZU ET AL., CLIN. CANCER RES., vol. 9, 2003, pages 774 - 778
NELSON ET AL., JOURNAL OF CLINICAL ONCOLOGY, vol. 12, 1994, pages 213 - 225
TERAWAKI ET AL., PLOS ONE, vol. 12, 2017, pages e0173113
ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING, vol. 6, 2019, pages 227 - 233
SUPPORT CARE CANCER, vol. 21, 2013, pages 2409 - 2415
JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE, vol. 5, 2014, pages 329 - 337
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
Download PDF: